Early-Stage Breast Cancer: New Developments and Controversies, An Issue of Surgical Oncology Clinics - E- Book

Author: Mamounas   Eleftherios P.  

Publisher: Elsevier Health Sciences‎

Publication year: 2010

E-ISBN: 9781455700707

Subject: C913 Social Life and Social Problems

Language: ENG

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Chapter

ADDITIONAL TAMOXIFEN BREAST CANCER PREVENTION TRIALS

RALOXIFENE STUDIES

THE STUDY OF TAMOXIFEN AND RALOXIFENE TRIAL, NSABP P-2

ADDITIONAL SERMS

AROMATASE INHIBITORS

2009 AMERICAN SOCIETY OF CLINICAL ONCOLOGY CLINICAL PRACTICE GUIDELINES ON THE USE OF PHARMACOLOGIC INTERVENTION, INCLUDING TAMOXIFEN, RALOXIFENE, AND AIS, FOR BREAST CANCER RISK REDUCTION

SUMMARY

REFERENCES

Chapter 2. Magnetic Resonance Imaging for Screening, Diagnosis, and Eligibility for Breast-conserving Surgery: Promises and Pitfalls

MRI FOR SCREENING

MRI FOR TREATMENT SELECTION

MRI FOR DETECTION OF LOCAL RECURRENCE

SUMMARY

REFERENCES

Chapter 3. Clinical Significance of Minimal Sentinel Node Involvement and Management Options

WHAT CONSTITUTES A POSITIVE SENTINEL LYMPH NODE?

TREATMENT OF SENTINEL NODE POSITIVE DISEASE: THE NEED FOR ALND?

PREDICTIVE MODELS

CLINICAL TRIALS

SUMMARY

REFERENCES

Chapter 4. Clinical Significance and Management of Extra-Axillary Sentinel Lymph Nodes: Worthwhile or Irrelevant?

INTERNAL MAMMARY SLNs

OTHER SITES OF NONAXILLARY SLN

SUMMARY

REFERENCES

Chapter 5. Sentinel Lymph Node Biopsy Before or After Neoadjuvant Chemotherapy: Pros and Cons

POTENTIAL ADVANTAGES TO SLN BIOPSY BEFORE NEOADJUVANT CHEMOTHERAPY

POTENTIAL ADVANTAGES TO SLN BIOPSY AFTER NEOADJUVANT CHEMOTHERAPY

MUST A POSITIVE PRETREATMENT SLN BIOPSY COMMIT A PATIENT TO AN ALND AFTER CHEMOTHERAPY?

IS SLN BIOPSY ACCURATE AFTER NEOADJUVANT CHEMOTHERAPY?

ACCURACY IN THE FACE OF CLINICALLY INVOLVED NODES BEFORE CHEMOTHERAPY

ACCURACY IN THE FACE OF CLINICALLY NEGATIVE NODES

IS IT SAFE TO AVOID ALND AFTER A NEGATIVE SLN BIOPSY FOLLOWING NEOADJUVANT CHEMOTHERAPY?

WHICH APPROACH PROVIDES THE MOST RELEVANT PROGNOSTIC/PREDICTIVE INFORMATION?

MUST ONE APPROACH BE UNIVERSALLY APPLIED?

REFERENCES

Chapter 6. Sentinel Lymph Node Surgery in Uncommon Clinical Circumstances

BREAST CANCER IN MEN

PREGNANT PATIENTS WITH BREAST CANCER

DUCTAL CARCINOMA IN SITU

MULTICENTRIC/MULTIFOCAL BREAST CANCER

NEOADJUVANT CHEMOTHERAPY

PREVIOUS BREAST SURGERY

PREVIOUS AXILLARY SURGERY

INTERNAL MAMMARY SLN SURGERY

PROPHYLACTIC MASTECTOMY

SUMMARY

REFERENCES

Chapter 7. Total Skin Sparing (Nipple Sparing) Mastectomy: What is the Evidence?

LITERATURE REVIEW

TECHNICAL CONSIDERATIONS

PATIENT SELECTION FOR TOTAL SKIN SPARING MASTECTOMY

TECHNICAL APPROACHES: INCISION PLANNING

TECHNICAL CONSIDERATIONS: CREATING SKIN FLAPS

DISCUSSION

REFERENCES

Chapter 8. Oncoplastic Surgery: A Creative Approach to Breast Cancer Management

HISTORICAL PERSPECTIVE

DEFINITION OF ONCOPLASTIC SURGERY

ONCOPLASTIC SURGERY AND BREAST CANCER

PREOPERATIVE ASSESSMENT

SURGICAL PLANNING

THE SMALL BREAST

THE LARGE BREAST

SUMMARY

REFERENCES

Chapter 9. Clinical Application of Gene Expression Profiling in Breast Cancer

PROGNOSTIC AND PREDICTIVE MARKERS

PROCESS FOR DEVELOPMENT OF A MULTIPARAMETER ASSAY

METHODS FOR ANALYZING GENE EXPRESSION

QUALITY CONTROL OF GENE EXPRESSION ANALYSIS METHODS

METHODS FOR BIOINFORMATICS ANALYSIS OF GENE EXPRESSION

VALIDITY, REPRODUCIBILITY, AND REPORTING OF MICROARRAY STUDIES

REGULATORY APPROVAL OF MULTIPARAMETER ASSAYS

CLASSIFIERS DEVELOPED BY SUPERVISED ANALYSIS

MULTIPARAMETER ASSAYS COMPARED WITH INTEGRATED CLINICAL INFORMATION

CLASSIFIERS DEVELOPED BY OTHER METHODS

WOUND-RESPONSE SIGNATURE

INVASIVE GENE SIGNATURE

PROSPECTIVE CLINICAL TRIALS EVALUATING MULTIPARAMETER ASSAYS

CLINICAL USEFULNESS OF MULTIPARAMETER ASSAYS AND CONCLUSIONS

REFERENCES

Chapter 10. Neoadjuvant Chemotherapy for Operable Breast Cancer: Individualizing Locoregional and Systemic Therapy

POTENTIAL BENEFITS OF NEOADJUVANT CHEMOTHERAPY FOR BREAST CANCER

PREDICTING RESPONSE TO NEOADJUVANT CHEMOTHERAPY

CHEMOTHERAPY VERSUS HORMONAL THERAPY

PRE-THERAPY ASSESSMENT AND STAGING

OPTIMAL CHEMOTHERAPY REGIMEN

ASSESSING RESPONSE TO NEOADJUVANT CHEMOTHERAPY

RESECTION OF THE PRIMARY TUMOR: BREAST CONSERVATION VERSUS MASTECTOMY

MANAGEMENT OF REGIONAL LYMPH NODES IN PATIENTS TREATED WITH NCT

POSTMASTECTOMY REGIONAL/CHEST WALL IRRADIATION AFTER NEOADJUVANT CHEMOTHERAPY

SUMMARY

REFERENCES

Chapter 11. Neoadjuvant Endocrine Therapy for Breast Cancer

TAMOXIFEN VERSUS SURGERY

AIS VERSUS TAMOXIFEN

NEOADJUVANT CHEMOTHERAPY VERSUS ENDOCRINE THERAPY

BIOMARKER EVALUATION IN THE NEOADJUVANT ENDOCRINE SETTING TO PREDICT LONG-TERM OUTCOME

RECEPTOR, HER2 STATUS AND SENSITIVITY TO ENDOCRINE THERAPY

WHICH AI IS SUPERIOR?

PATIENT SELECTION FOR NEOADJUVANT CHEMOTHERAPY

NEW COMBINATIONS WITH ENDOCRINE THERAPY IN THE NEOADJUVANT SETTING

SUMMARY

REFERENCES

Chapter 12. Adjuvant Hormonal Therapy for Early-Stage Breast Cancer

TAMOXIFEN

ADJUVANT ENDOCRINE THERAPY FOR POSTMENOPAUSAL WOMEN WITH HORMONE RECEPTOR–POSITIVE EARLY-STAGE BREAST CANCER

ADJUVANT ENDOCRINE THERAPY FOR PREMENOPAUSAL WOMEN WITH HORMONE RECEPTOR–POSITIVE EARLY-STAGE BREAST CANCER

SUMMARY

REFERENCES

Chapter 13. Adjuvant Chemotherapy in Early-Stage Breast Cancer: What, When, and for Whom?

WHO SHOULD BE CONSIDERED FOR ADJUVANT CHEMOTHERAPY?

WHAT ADJUVANT CHEMOTHERAPY?

TUMOR BIOLOGY AND CHOICE OF ADJUVANT CHEMOTHERAPY

ADJUVANT CHEMOTHERAPY WHEN?

SUMMARY

REFERENCES

Chapter 14. Targeted Therapies in Early-Stage Breast Cancer: Achievements and Promises

WHAT IS MEANT BY TARGETED THERAPY?

TARGETED THERAPY IN THE CONTEXT OF GENOMICS

HER2-TARGETED THERAPY

NOVEL APPROACHES: ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY

NOVEL APPROACHES: CHEMOTHERAPY AS TARGETED THERAPY

NOVEL APPROACHES: PARP INHIBITION FOR TRIPLE-NEGATIVE (BASAL) BREAST CANCER

NOVEL APPROACHES: TARGETING SITE-SPECIFIC BONE METASTASIS

SUMMARY

REFERENCES

Index

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