Chapter
EXTRARENAL 1-HYDROXYLASE (1α(OH)ASE)
VITAMIN D P450S IN AGING AND CHRONIC KIDNEY DISEASE
Chapter 2. The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25- Dihydroxyvitamin D3
VDR STRUCTURE AND FUNCTION
NEW APPROACHES REVEAL NEW INSIGHTS INTO VITAMIN D3–MEDIATED GENE REGULATION
GENOME-WIDE STUDIES REVEAL OVERARCHING PRINCIPLES OF GENE REGULATION
Chapter 3. Assessment and Interpretation of Circulating 25- Hydroxyvitamin D and 1,25-Dihydroxyvitamin D in the Clinical Environment
METHODS OF 25(OH)D QUANTITATION
DETERMINING ANALYTICAL RECOVERY OF 25(OH)D2 AND 25(OH)D3 IN HUMAN SERUM OR PLASMA
DETERMINING AND DEFINING A ‘‘NORMAL’’ CIRCULATING 25(OH)D LEVEL
CLINICAL REPORTING OF CIRCULATING 25(OH)D CONCENTRATIONS
METHODS OF 1,25(OH)2D QUANTITATION
DETERMINING AND DEFINING A ‘‘NORMAL’’ CIRCULATING 1,25(OH)2D LEVEL
STABILITY OF 25(OH)D AND 1,25(OH)2D IN SERUM OR PLASMA
STANDARDIZATION OF 25(OH)D AND 1,25(OH)2D ANALYSIS
Chapter 4. Low Vitamin D Status: Definition, Prevalence, Consequences, and Correction
VITAMIN D BACKGROUND AND ASSESSMENT
LOW VITAMIN D STATUS: DEFINITION AND PREVALENCE
LOW VITAMIN D STATUS: CONSEQUENCES
APPROACHES TO VITAMIN D REPLETION/SUPPLEMENTATION
WHAT IS VITAMIN D TOXICITY?
DOES THE EFFECT OF VITAMIN D2 DIFFER FROM THAT OF VITAMIN D3?
Chapter 5. Maternal Vitamin D Status: Implications for the Development of Infantile Nutritional Rickets
CAUSE AND EPIDEMIOLOGY OF INFANTILE NUTRITIONAL RICKETS
VITAMIN D AND CALCIUM HOMEOSTASIS IN THE MOTHER-INFANT PAIR DURING PREGNANCY AND LACTATION
CONSEQUENCES OF VITAMIN D DEFICIENCY IN MOTHER-INFANT PAIRS
RECOMMENDATIONS FOR THE PREVENTION OF VITAMIN D DEFICIENCY IN MOTHER AND CHILD
Chapter 6. Osteomalacia as a Result of Vitamin D Deficiency
HISTORICAL PERSPECTIVE AND SCOPE OF THE PROBLEM
CLINICAL MANIFESTATIONS OF OSTEOMALACIA
RADIOLOGICAL FEATURES OF OSTEOMALACIA
BIOCHEMICAL CHANGES IN OSTEOMALACIA
DIAGNOSTIC APPROACH TO OSTEOMALACIA
TREATMENT OF OSTEOMALACIA
Chapter 7. Genetic Disorders and Defects in Vitamin D Action
1a-HYDROXYLASE DEFICIENCY IN CHILDREN
MUTATIONS IN THE CYP27B1 GENE AS THE MOLECULAR BASIS FOR 1a-HYDROXYLASE DEFICIENCY
MOUSE MODELS OF 1α-HYDROXYLASE DEFICIENCY
MUTATIONS IN THE VDR GENE AS THE MOLECULAR BASIS FOR HVDRR
Chapter 8. Vitamin D and Fracture Prevention
VITAMIN D: ITS ROLE IN MUSCLE HEALTH
VITAMIN D: ITS ROLE IN BONE HEALTH
ADDING CALCIUM TO VITAMIN D
Chapter 9. Vitamin D in Kidney Disease: Pathophysiology and the Utility of Treatment
NORMAL VITAMIN D PHYSIOLOGY
VITAMIN D METABOLISM IN KIDNEY DISEASE
ROLE OF VITAMIN D TREATMENT IN CKD-MBD
EFFECTS OF VITAMIN D ON THE CARDIOVASCULAR SYSTEM
VITAMIN D AND OVERALL SURVIVAL
OTHER POTENTIALLY BENEFICIAL EFFECTS OF VITAMIN D TREATMENT IN CKD
Chapter 10. Vitamin D and the Immune System: New Perspectives on an Old Theme
VITAMIN D AND INNATE IMMUNITY
VITAMIN D AND ADAPTIVE IMMUNITY
VITAMIN D, THE IMMUNE SYSTEM AND HUMAN HEALTH
Chapter 11. Vitamin D: Extraskeletal Health
HISTORICAL PERSPECTIVE ON EXTRASKELETAL EFFECTS OF VITAMIN D
VITAMIN D AND AUTOIMMUNE DISEASES
Chapter 12. The Role of Vitamin D in Cancer Prevention and Treatment
MECHANISMS OF THE ANTICANCER EFFECTS OF CALCITRIOL
ANTICANCER EFFECTS OF CALCITRIOL IN ANIMAL MODELS
Chapter 13. Vitamin D and Diabetes
VITAMIN D AND DIABETES COMPLICATIONS
Chapter 14. Vitamin D Analogs
PHARMACOLOGICALLY IMPORTANT VITAMIN D COMPOUNDS
CLINICAL APPLICATIONS OF VITAMIN D COMPOUNDS
CRITERIA THAT INFLUENCE PHARMACOLOGIC EFFECTS OF VITAMIN D COMPOUNDS
MEMBRANE RECEPTORS AND NONGENOMIC EFFECTS OF VITAMIN D ANALOGS
PROPOSED MOLECULAR MECHANISMS OF ACTION OF VITAMIN D COMPOUNDS