Vitamin D, An Issue of Endocrinology and Metabolism Clinics of North America,

Author: Epstein   Sol  

Publisher: Elsevier Health Sciences‎

Publication year: 2010

E-ISBN: 9781455700264

Subject: G42 TEACHING METHODS AND CURRICULUM

Language: ENG

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Chapter

EXTRARENAL 1-HYDROXYLASE (1α(OH)ASE)

VITAMIN D P450S IN AGING AND CHRONIC KIDNEY DISEASE

REFERENCES

Chapter 2. The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25- Dihydroxyvitamin D3

VDR STRUCTURE AND FUNCTION

VITAMIN D TARGET GENES

NEW APPROACHES REVEAL NEW INSIGHTS INTO VITAMIN D3–MEDIATED GENE REGULATION

GENOME-WIDE STUDIES REVEAL OVERARCHING PRINCIPLES OF GENE REGULATION

SUMMARY

ACKNOWLEDGMENTS

REFERENCES

Chapter 3. Assessment and Interpretation of Circulating 25- Hydroxyvitamin D and 1,25-Dihydroxyvitamin D in the Clinical Environment

METHODS OF 25(OH)D QUANTITATION

DETERMINING ANALYTICAL RECOVERY OF 25(OH)D2 AND 25(OH)D3 IN HUMAN SERUM OR PLASMA

DETERMINING AND DEFINING A ‘‘NORMAL’’ CIRCULATING 25(OH)D LEVEL

CLINICAL REPORTING OF CIRCULATING 25(OH)D CONCENTRATIONS

METHODS OF 1,25(OH)2D QUANTITATION

DETERMINING AND DEFINING A ‘‘NORMAL’’ CIRCULATING 1,25(OH)2D LEVEL

STABILITY OF 25(OH)D AND 1,25(OH)2D IN SERUM OR PLASMA

STANDARDIZATION OF 25(OH)D AND 1,25(OH)2D ANALYSIS

SUMMARY

REFERENCES

Chapter 4. Low Vitamin D Status: Definition, Prevalence, Consequences, and Correction

VITAMIN D BACKGROUND AND ASSESSMENT

LOW VITAMIN D STATUS: DEFINITION AND PREVALENCE

LOW VITAMIN D STATUS: CONSEQUENCES

APPROACHES TO VITAMIN D REPLETION/SUPPLEMENTATION

WHAT IS VITAMIN D TOXICITY?

DOES THE EFFECT OF VITAMIN D2 DIFFER FROM THAT OF VITAMIN D3?

SUMMARY

REFERENCES

Chapter 5. Maternal Vitamin D Status: Implications for the Development of Infantile Nutritional Rickets

CAUSE AND EPIDEMIOLOGY OF INFANTILE NUTRITIONAL RICKETS

VITAMIN D AND CALCIUM HOMEOSTASIS IN THE MOTHER-INFANT PAIR DURING PREGNANCY AND LACTATION

CONSEQUENCES OF VITAMIN D DEFICIENCY IN MOTHER-INFANT PAIRS

RECOMMENDATIONS FOR THE PREVENTION OF VITAMIN D DEFICIENCY IN MOTHER AND CHILD

SUMMARY

REFERENCES

Chapter 6. Osteomalacia as a Result of Vitamin D Deficiency

HISTORICAL PERSPECTIVE AND SCOPE OF THE PROBLEM

CLINICAL MANIFESTATIONS OF OSTEOMALACIA

RADIOLOGICAL FEATURES OF OSTEOMALACIA

SKELETAL FRACTURES

BIOCHEMICAL CHANGES IN OSTEOMALACIA

DIAGNOSTIC APPROACH TO OSTEOMALACIA

TREATMENT OF OSTEOMALACIA

REFERENCES

Chapter 7. Genetic Disorders and Defects in Vitamin D Action

1a-HYDROXYLASE DEFICIENCY IN CHILDREN

MUTATIONS IN THE CYP27B1 GENE AS THE MOLECULAR BASIS FOR 1a-HYDROXYLASE DEFICIENCY

MOUSE MODELS OF 1α-HYDROXYLASE DEFICIENCY

HVDRR IN CHILDREN

MUTATIONS IN THE VDR GENE AS THE MOLECULAR BASIS FOR HVDRR

MOUSE MODELS OF HVDRR

THERAPY FOR HVDRR

ALOPECIA

SUMMARY

REFERENCES

Chapter 8. Vitamin D and Fracture Prevention

GOING BEYOND BONE

VITAMIN D: ITS ROLE IN MUSCLE HEALTH

VITAMIN D: ITS ROLE IN BONE HEALTH

ADDING CALCIUM TO VITAMIN D

SUMMARY

REFERENCES

Chapter 9. Vitamin D in Kidney Disease: Pathophysiology and the Utility of Treatment

CALCIUM

CKD-MBD

NORMAL VITAMIN D PHYSIOLOGY

VITAMIN D METABOLISM IN KIDNEY DISEASE

PHOSPHORUS

ROLE OF VITAMIN D TREATMENT IN CKD-MBD

EFFECTS OF VITAMIN D ON THE CARDIOVASCULAR SYSTEM

VITAMIN D AND OVERALL SURVIVAL

OTHER POTENTIALLY BENEFICIAL EFFECTS OF VITAMIN D TREATMENT IN CKD

SUMMARY

REFERENCES

Chapter 10. Vitamin D and the Immune System: New Perspectives on an Old Theme

HISTORICAL PERSPECTIVE

VITAMIN D AND INNATE IMMUNITY

VITAMIN D AND ADAPTIVE IMMUNITY

VITAMIN D, THE IMMUNE SYSTEM AND HUMAN HEALTH

SUMMARY

REFERENCES

Chapter 11. Vitamin D: Extraskeletal Health

SOURCES OF VITAMIN D

HISTORICAL PERSPECTIVE ON EXTRASKELETAL EFFECTS OF VITAMIN D

CANCER PREVENTION

PSORIASIS

VITAMIN D AND AUTOIMMUNE DISEASES

INNATE IMMUNITY

CARDIOVASCULAR HEALTH

TYPE 2 DIABETES

SUMMARY

REFERENCES

Chapter 12. The Role of Vitamin D in Cancer Prevention and Treatment

EPIDEMIOLOGY

MECHANISMS OF THE ANTICANCER EFFECTS OF CALCITRIOL

ANTICANCER EFFECTS OF CALCITRIOL IN ANIMAL MODELS

CLINICAL STUDIES

SUMMARY

REFERENCES

Chapter 13. Vitamin D and Diabetes

TYPE 1 DIABETES

TYPE 2 DIABETES

GESTATIONAL DIABETES

VITAMIN D AND DIABETES COMPLICATIONS

SUMMARY

REFERENCES

Chapter 14. Vitamin D Analogs

PHARMACOLOGICALLY IMPORTANT VITAMIN D COMPOUNDS

CLINICAL APPLICATIONS OF VITAMIN D COMPOUNDS

CRITERIA THAT INFLUENCE PHARMACOLOGIC EFFECTS OF VITAMIN D COMPOUNDS

VDR/RXR/VDRE

MEMBRANE RECEPTORS AND NONGENOMIC EFFECTS OF VITAMIN D ANALOGS

PROPOSED MOLECULAR MECHANISMS OF ACTION OF VITAMIN D COMPOUNDS

FUTURE PROSPECTS

ACKNOWLEDGMENTS

REFERENCES

Index

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