Chapter
RELATIONSHIPS OF THE SELLA TURCICA
ANTERIOR PITUITARY HORMONES AND FEEDBACK CONTROL
POSTERIOR PITUITARY GLAND
MANIFESTATIONS OF SUPRASELLAR DISEASE
EFFECTS OF PITUITARY TUMORS ON THE VISUAL APPARATUS
NONTUMOROUS LESIONS OF THE PITUITARY GLAND AND PITUITARY STALK
PITUITARY ANTERIOR LOBE DEFICIENCY IN CHILDHOOD AND ADOLESCENCE IN BOYS
PITUITARY ANTERIOR LOBE DEFICIENCY IN ADULTS
SELECTIVE AND PARTIAL HYPOPITUITARISM
SEVERE ANTERIOR PITUITARY DEFICIENCY OR PANHYPOPITUITARISM
POSTPARTUM PITUITARY INFARCTION (SHEEHAN SYNDROME)
PROLACTIN-SECRETING PITUITARY TUMOR
CORTICOTROPIN-SECRETING PITUITARY TUMOR
CLINICALLY NONFUNCTIONING PITUITARY TUMOR
SECRETION AND ACTION OF OXYTOCIN
SECRETION AND ACTION OF VASOPRESSIN
CENTRAL DIABETES INSIPIDUS
LANGERHANS CELL HISTIOCYTOSIS IN CHILDREN
LANGERHANS CELL HISTIOCYTOSIS IN ADULTS
TUMORS METASTATIC TO THE PITUITARY
SURGICAL APPROACHES TO THE PITUITARY
ANATOMY OF THE THYROID AND PARATHYROID GLANDS
DEVELOPMENT OF THE THYROID AND PARATHYROID GLANDS
PARATHYROID AND THYMUS GLANDS
CONGENITAL ANOMALIES OF THE THYROID GLAND
EFFECTS OF THYROTROPIN ON THE THYROID GLAND
PHYSIOLOGY OF THYROID HORMONES
THYROID PATHOLOGY IN GRAVES DISEASE
CLINICAL MANIFESTATIONS OF TOXIC ADENOMA AND TOXIC MULTINODULAR GOITER
PATHOPHYSIOLOGY OF TOXIC ADENOMA AND TOXIC MULTINODULAR GOITER
CLINICAL MANIFESTATIONS OF HYPOTHYROIDISM IN ADULTS
CONGENITAL HYPOTHYROIDISM
GROSS PATHOLOGY OF GOITER
ETIOLOGY OF NONTOXIC GOITER
CHRONIC LYMPHOCYTIC THYROIDITIS AND FIBROUS THYROIDITIS
CHRONIC LYMPHOCYTIC (HASHIMOTO) THYROIDITIS
FIBROUS (RIEDEL) THYROIDITIS
PAPILLARY THYROID CARCINOMA
FOLLICULAR THYROID CARCINOMA
MEDULLARY THYROID CARCINOMA
HüRTHLE CELL THYROID CARCINOMA
ANAPLASTIC THYROID CARCINOMA
TUMORS METASTATIC TO THE THYROID
DEVELOPMENT OF THE ADRENAL GLANDS
ANATOMY AND BLOOD SUPPLY OF THE ADRENAL GLANDS
SURGICAL APPROACHES TO THE ADRENAL GLANDS
INNERVATION OF THE ADRENAL GLANDS
HISTOLOGY OF THE ADRENAL GLANDS
BIOSYNTHESIS AND METABOLISM OF ADRENAL CORTICAL HORMONES
THE BIOLOGIC ACTIONS OF CORTISOL
CARBOHYDRATE, PROTEIN, AND LIPID METABOLISM
SKIN, MUSCLE, AND CONNECTIVE TISSUES
BONE AND CALCIUM METABOLISM
CENTRAL NERVOUS SYSTEM AND EYES
CUSHING SYNDROME—CLINICAL FINDINGS
TESTS USED IN THE DIAGNOSIS OF CUSHING SYNDROME
CUSHING SYNDROME: PATHOPHYSIOLOGY
ADRENOCORTICOTROPIC HORMONE–DEPENDENT CUSHING SYNDROME
ADRENOCORTICOTROPIC HORMONE–INDEPENDENT CUSHING SYNDROME
CUSHING SYNDROME CAUSED BY PRIMARY PIGMENTED NODULAR ADRENOCORTICAL DISEASE
MAJOR BLOCKS IN ABNORMAL STEROIDOGENESIS
I. CONGENITAL LIPOID HYPERPLASIA
II. 3β-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY
III. 17α-HYDROXYLASE DEFICIENCY
IV. 21-HYDROXYLASE DEFICIENCY
V. 11β-HYDROXYLASE DEFICIENCY
CLASSIC CONGENITAL ADRENAL HYPERPLASIA
CONGENITAL LIPOID HYPERPLASIA
3β-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY
17α-HYDROXYLASE DEFICIENCY
21-HYDROXYLASE DEFICIENCY
11β-HYDROXYLASE DEFICIENCY
APPARENT MINERALOCORTICOID EXCESS
THE BIOLOGIC ACTIONS OF ADRENAL ANDROGENS
ADULT ANDROGENITAL SYNDROMES
LATE-ONSET (NONCLASSIC) CONGENITAL ADRENAL HYPERPLASIA
FAMILIAL GLUCOCORTICOID RESISTANCE
ADRENOCORTICOTROPIC HORMONE–DEPENDENT CUSHING SYNDROME
ANDROGEN-SECRETING ADRENAL NEOPLASMS
THE BIOLOGIC ACTIONS OF ALDOSTERONE
ADRENAL VENOUS SAMPLING FOR PRIMARY ALDOSTERONISM
RENIN–ANGIOTENSIN–ALDOSTERONE SYSTEM AND RENOVASCULAR HYPERTENSION
ACUTE ADRENAL FAILURE—ADRENAL CRISIS
CHRONIC PRIMARY ADRENAL FAILURE—ADDISON DISEASE
LABORATORY FINDINGS AND TREATMENT OF PRIMARY ADRENAL INSUFFICIENCY
LABORATORY FINDINGS AND TREATMENT OF SECONDARY ADRENAL INSUFFICIENCY
ADRENAL MEDULLA AND CATECHOLAMINES
CATECHOLAMINE SYNTHESIS, STORAGE, SECRETION, METABOLISM, AND INACTIVATION
CATECHOLAMINE STORAGE AND SECRETION
CATECHOLAMINE METABOLISM AND INACTIVATION
PHEOCHROMOCYTOMA AND PARAGANGLIOMA
TUMORS METASTATIC TO THE ADRENAL GLANDS
DIFFERENTIATION OF GONADS
FACTORS INFLUENCING NORMAL AND ABNORMAL GONADAL DIFFERENTIATION
STAGES IN GONADAL DIFFERENTIATION
DIFFERENTIATION OF GENITAL DUCTS
DIFFERENTIATION OF EXTERNAL GENITALIA
TESTOSTERONE AND ESTROGEN SYNTHESIS
GONADOTROPIN-DEPENDENT PRECOCIOUS PUBERTY
GONADOTROPIN-INDEPENDENT PRECOCIOUS PUBERTY
INCOMPLETE PRECOCIOUS PUBERTY
DIAGNOSTIC EVALUATION AND TREATMENT
DISORDERS OF SEX DEVELOPMENT
SEX CHROMOSOME DISORDERS OF SEX DEVELOPMENT
46,XX DISORDERS OF SEX DEVELOPMENT
46,XY DISORDERS OF SEX DEVELOPMENT
ERRORS IN CHROMOSOMAL SEX
TURNER SYNDROME (GONADAL DYSGENESIS)
HIRSUTISM AND VIRILIZATION
EVALUATION OF WOMEN WITH HIRSUTISM
INFLUENCE OF GONADAL HORMONES ON THE FEMALE REPRODUCTIVE CYCLE FROM BIRTH TO OLD AGE
FUNCTIONAL AND PATHOLOGIC CAUSES OF UTERINE BLEEDING
PANCREAS ANATOMY AND HISTOLOGY
EXOCRINE FUNCTIONS OF THE PANCREAS
NORMAL HISTOLOGY OF PANCREATIC ISLETS
REGULATION OF GLYCOGENESIS AND GLYCOGENOLYSIS
CONSEQUENCES OF INSULIN DEPRIVATION
NONPROLIFERATIVE DIABETIC RETINOPATHY
PROLIFERATIVE DIABETIC RETINOPATHY
COMPLICATIONS OF PROLIFERATIVE DIABETIC RETINOPATHY
PROXIMAL MOTOR NEUROPATHIES
DISTAL SYMMETRIC POLYNEUROPATHY
ATHEROSCLEROSIS IN DIABETES
CARDIOVASCULAR RISK REDUCTION
VASCULAR INSUFFICIENCY IN DIABETES: THE DIABETIC FOOT
DIABETES MELLITUS IN PREGNANCY
TREATMENT OF TYPE 2 DIABETES MELLITUS
INITIAL APPROACH TO MEDICAL MANAGEMENT
TREATMENT OF TYPE 1 DIABETES MELLITUS
MONOMERIC INSULIN ANALOGUES
LONG-ACTING INSULIN ANALOGUES
CONTINUOUS SUBCUTANEOUS INSULIN INFUSION AND MULTIPLE DAILY INJECTIONS
PRIMARY PANCREATIC β-CELL HYPERPLASIA
CONGENITAL HYPERINSULINISM
NONINSULINOMA PANCREATOGENOUS HYPOGLYCEMIA SYNDROME AND POST–GASTRIC BYPASS HYPOGLYCEMIA
SECTION 6: BONE AND CALCIUM
HISTOLOGY OF THE NORMAL PARATHYROID GLANDS
PHYSIOLOGY OF THE PARATHYROID GLANDS
DEFECTIVE BONE REMODELING
PATHOPHYSIOLOGY OF PRIMARY HYPERPARATHYROIDISM
PATHOLOGY AND CLINICAL MANIFESTATIONS OF PRIMARY HYPERPARATHYROIDISM
TESTS FOR THE DIFFERENTIAL DIAGNOSIS OF THE CAUSES OF HYPERCALCEMIA
PARATHYROID HORMONE–MEDIATED HYPERCALCEMIA
NON–PARATHYROID HORMONE–MEDIATED HYPERCALCEMIA
OTHER CAUSES OF APPARENT HYPERCALCEMIA
HISTOLOGY OF THE PARATHYROID GLANDS IN HYPERPARATHYROIDISM
PRIMARY CHIEF CELL HYPERPLASIA
PRIMARY CLEAR CELL HYPERPLASIA
SECONDARY PARATHYROID GLAND HYPERPLASIA
PATHOPHYSIOLOGY OF HYPOPARATHYROIDISM
GENETIC CAUSES OF HYPOPARATHYROIDISM
PSEUDOHYPOPARATHYROIDISM—HYPOCALCEMIA DESPITE A HIGH SERUM PARATHYROID HORMONE CONCENTRATION
CLINICAL MANIFESTATIONS OF ACUTE HYPOCALCEMIA
PATHOPHYSIOLOGY OF PSEUDOHYPOPARATHYROIDISM
PSEUDOHYPOPARATHYROIDISM TYPE 1
PSEUDOHYPOPARATHYROIDISM TYPE 2
CLINICAL MANIFESTATIONS OF PSEUDOHYPOPARATHYROIDISM TYPE 1A
PATHOGENESIS OF OSTEOPOROSIS
OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN
CLINICAL MANIFESTATIONS OF OSTEOPOROTIC VERTEBRAL COMPRESSION FRACTURES
NUTRITIONAL-DEFICIENCY RICKETS AND OSTEOMALACIA
PSEUDOVITAMIN D–DEFICIENCY RICKETS AND OSTEOMALACIA
TYPE 1 PSEUDOVITAMIN D–DEFICIENT RICKETS: RENAL 1α-HYDROXYLASE DEFICIENCY
TYPE 2 PSEUDOVITAMIN D–DEFICIENT RICKETS: HEREDITARY VITAMIN D–RESISTANT RICKETS
X-LINKED HYPOPHOSPHATEMIC RICKETS
TUMOR-INDUCED OSTEOMALACIA
CLINICAL MANIFESTATIONS OF RICKETS IN CHILDHOOD
CLINICAL MANIFESTATIONS OF OSTEOMALACIA IN ADULTS
PAGET DISEASE OF THE BONE
PATHOGENESIS AND TREATMENT OF PAGET DISEASE OF THE BONE
SECTION 7: LIPIDS AND NUTRITION
CHOLESTEROL SYNTHESIS AND METABOLISM
GASTROINTESTINAL ABSORPTION OF CHOLESTEROL AND TRIGLYCERIDES
REGULATION OF LOW-DENSITY LIPOPROTEIN RECEPTOR AND CHOLESTEROL CONTENT
HIGH-DENSITY LIPOPROTEIN METABOLISM AND REVERSE CHOLESTEROL TRANSPORT
HYPERCHOLESTEROLEMIC XANTHOMATOSIS
FAMILIAL HYPERCHOLESTEROLEMIA—LOW-DENSITY LIPOPROTEIN RECEPTOR MUTATIONS
FAMILIAL DEFECTIVE APOLIPOPROTEIN B100
SITOSTEROLEMIA AND CEREBROTENDINOUS XANTHOMATOSIS
ABETALIPOPROTEINEMIA AND TANGIER DISEASE
CLINICAL MANIFESTATIONS OF HYPERTRIGLYCERIDEMIA
LIPOPROTEIN LIPASE DEFICIENCY
APOLIPOPROTEIN CII DEFICIENCY
FAMILIAL HYPERTRIGLYCERIDEMIA
ATHEROSCLEROSIS RISK FACTORS
MECHANISMS OF ACTION OF LIPID-LOWERING AGENTS
CHOLESTEROL ABSORPTION INHIBITORS
TREATMENT OF HYPERLIPIDEMIA
RAISING HIGH-DENSITY LIPOPROTEIN CHOLESTEROL
ABSORPTION OF ESSENTIAL VITAMINS
VITAMIN B1 DEFICIENCY: BERIBERI
WERNICKE-KORSAKOFF SYNDROME
VITAMIN B3 DEFICIENCY: PELLAGRA
VITAMIN C DEFICIENCY: SCURVY
CELIAC DISEASE AND MALABSORPTION
LYSOSOMAL STORAGE DISORDERS: SPHINGOLIPIDOSES
METACHROMATIC LEUKODYSTROPHY
SURGICAL TREATMENT OPTIONS FOR OBESITY
SECTION 8: GENETICS AND ENDOCRINE NEOPLASIA
MULTIPLE ENDOCRINE NEOPLASIA TYPE 1
MULTIPLE ENDOCRINE NEOPLASIA TYPE 2
MEDULLARY THYROID CARCINOMA
PRIMARY HYPERPARATHYROIDISM
CUTANEOUS LICHEN AMYLOIDOSIS
VON HIPPEL–LINDAU SYNDROME
NEUROFIBROMATOSIS TYPE 1 (VON RECKLINGHAUSEN DISEASE)
CLINICAL MANIFESTATIONS OF AUTOIMMUNE POLYGLANDULAR SYNDROME TYPE 1
GLOSSARY OF ABBREVIATIONS
Section 1: Pituitary and Hypothalamus
Section 6: Bone and Calcium
Section 7: Lipids and Nutrition
Section 8: Genetics and Endocrine Neoplasia