Chapter
Elliott Proctor Joslin (1869-1962)
Israel Kleiner (1885-1966)
Nicolae Constantine Paulescu (1869-1931)
Sir Frederick Grant Banting (1891-1941)
Section one: Medical issues in pediatric endocrinology
Endocrinology in the newborn
Growth in the neonatal period
Hypothyroxinemia in preterm babies
Babies born to mothers with thyroid disease
Disorders of sexual differentiation (DSD)
Common newborn endocrinologic conditions
Disorders of glucose metabolism
Disorders of sodium metabolism
Disorders of calcium metabolism
Addendum: The Endocrinology System and the Newborn
Anatomy and Developmental Physiology
Laboratory, imaging and referral for endocrine disorders
Endocrine disorders in primary care
Congenital hypothyroidism (CH)
Adrenal disorders (CAH/adrenal insufficiency)
Congenital adrenal hyperplasia
Disorders of sex development (DSD)/ ambiguous genitalia (AG)
Polycystic ovarian syndrome (PCOS)
Treatment for acne and hirsutism
Immunology of diabetes mellitus type 1
Histologic considerations
Concept of autoantibodies
Autoimmune therapeutic issues
Diabetes in children and adolescents
Diagnostic considerations
Management considerations
Main components of T1DM management
Management considerations
Genetic forms of diabetes
Hyperlipidemia in children with
Pediatric Cardiology, St John Providence Children’s Hospital, Wayne State University School of Medicine, Detroit, Michigan, US
Why screen, evaluate and manage
pediatric hyperlipidemia?
Risk factors for ASCVD and hyperlipidemia
Physiology of lipid metabolism
Pathophysiology of atherosclerosis
Classification of hyperlipidemias
Primary causes of hyperlipidemias
Secondary causes of hyperlipidemia
Overweight/obesity/nutrition
Evaluation of hyperlipidemia in patients with
Physical exam (lipid deposition) findings
Management of hyperlipidemia
Hypertension in children: A review
Screening for hypertension
Hypertension with renal parenchymal abnormalities
Renovascular hypertension
Glucocorticoid remediable aldosteronism
Congenital adrenal hyperplasia
Syndrome of apparent mineralocorticoid excess (AME)
Genetic syndromes associated with pheochromocytoma
Neurofibromatosis type 1 (NF1)
von Hippel –Lindau disease (VHL)
Succinate dehydrogenase (SDH) mutations
Laboratory and imaging evaluation
Concepts of metabolic disorders
Maple syrup urine disease (MSUD)
Adrenoleukodystrophy (ALD)
Metachromatic leukodystrophy (MLD)
Glycogen storage disease Type I
Glycogen storage disease Type II
Nieman-Pick disease (NPD)
Late-onset GM1 gangliosidosis
Late-onset GM2 gangliosidosis
Late-onset urea cycle disorders
Ornithine transcarbamylase deficiency
Mevalonate kinase deficiency (MKD)
Adenosine deaminase and purine phosphorylase deficiencies
Perspectives in pediatric pain: Chronic abdominal pain
Dermatological manifestations of pancreatic disorders
Diabetic cheiroarthropathy
Acanthosis nigricans (AN)
Scleredema adultorum of Buschke
Necrobiosis lipoidica diabetricorum (NLD)
Bullosis diabeticorum (BD)
Acquired perforating dermatosis (APD)
Nutrient deficiency dermatitis
Drug hypersensitivity reactions
Necrolytic migratory erythema (NME)
Familial atypical multiple mole melanoma-pancreatic cancer syndrome
Congenital malformations of the pancreas
Department of Pediatric and Adolescent Medicine, Western Michigan University Homer Stryker MD School of Medicine and Ferris State University School of Pharmacy, Kalamazoo, Michigan, United States of America
Treatment of nocturnal enuresis
Non-pharmacologic methods
Tricyclic antidepressants
Transition of pediatric endocrine patients to adult care
Management considerations
Congenital adrenal hyperplasia (CAH)
Diagnostic considerations
CAH therapeutic management
Transition of care to adults
Section two: Behavioral issues of chronic disease, palliative care and death
Behavioral aspects of chronic illness
Physicians use of brief counseling models in a pediatric outpatient setting
Role of the physician-patient relationship
Considerations in a pediatric setting
Health risk behavior models
Motivation and commitment models
Stages of change (transtheoretical model)
Coping and adaptation to chronic illness and disability for children and adolescents: Focus on type 1 diabetes
Adaptation – Focus on type 1 diabetes
Psychosocial adaptation and physiological adaptation
Common chronic illnesses and disabilities
Coping and adaptation to chronic illness and type 1 diabetes
Overarching concepts of coping and adaptation
Concepts of coping and adaptation
Child and adolescent developmental considerations
When to conduct psychosocial adaptation assessment
Assessment: Focus on type 1 diabetes
Treatment and intervention
Barriers and facilitators influencing the diabetes treatment regimen for adolescents
Physician characteristics
Physician-patient relationship
Physician characteristics
Chronic disease and the dying adolescent
Effects of dying on adolescent development
Issues with adolescent consent, accent, or refusal of treatment
Issues for health care professionals and hospital staff
Impending death of the teen patient
Management concepts for the hospital staff
Section three: Acknowledgments
About the Department of Pediatric and Adolescent Medicine, Western Michigan University Homer Stryker MD School of Medicine (WMED), Kalamazoo, Michigan USA
About the Nationwide Children’s Hospital, Columbus, Ohio, United States
About the National Institute of Child Health and Human Development in Israel
Service and academic activities
International collaborations
About the book series “Pediatrics, child and adolescent health”
Chronic Disease and Disability: The Pediatric Pancreas
( Pediatrics, Child and Adolescent Health (Series Editor: Joav Merrick - National Institute of Child Health and Human Development, Ministry of Social Affairs, Jerusalem) )
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