Mathematics for Neuroscientists ( 2 )

Publication series :2

Author: Gabbiani   Fabrizio;Cox   Steven James  

Publisher: Elsevier Science‎

Publication year: 2017

E-ISBN: 9780128019061

P-ISBN(Paperback): 9780128018958

Subject: Q189 Neurobiology

Keyword: 神经科学,普通生物学

Language: ENG

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Description

Mathematics for Neuroscientists, Second Edition, presents a comprehensive introduction to mathematical and computational methods used in neuroscience to describe and model neural components of the brain from ion channels to single neurons, neural networks and their relation to behavior. The book contains more than 200 figures generated using Matlab code available to the student and scholar. Mathematical concepts are introduced hand in hand with neuroscience, emphasizing the connection between experimental results and theory.

  • Fully revised material and corrected text
  • Additional chapters on extracellular potentials, motion detection and neurovascular coupling
  • Revised selection of exercises with solutions
  • More than 200 Matlab scripts reproducing the figures as well as a selection of equivalent Python scripts

Chapter

3 Differential Equations

3.1 Exact Solution

3.2 Moment Methods*

3.3 The Laplace Transform*

3.4 Numerical Methods

3.5 Synaptic Input

3.6 Summary and Sources

3.7 Exercises

4 The Active Isopotential Cell

4.1 The Delayed Rectifier Potassium Channel

4.2 The Sodium Channel

4.3 The Hodgkin-Huxley Equations

4.4 The Transient Potassium Channel*

4.5 The Sodium-Potassium Pump*

4.6 Summary and Sources

4.7 Exercises

5 The Quasi-Active Isopotential Cell

5.1 The Quasi-Active Model

5.2 Numerical Methods

5.3 Exact Solution via Eigenvector Expansion

5.4 A Persistent Sodium Current*

5.5 A Nonspecific Cation Current that is Activated by Hyperpolarization*

5.6 Linearization of the Sodium-Potassium Pump*

5.7 Summary and Sources

5.8 Exercises

6 The Passive Cable

6.1 The Discrete Passive Cable Equation

6.2 Exact Solution via Eigenvector Expansion

6.3 Numerical Methods

6.4 The Passive Cable Equation

6.5 Synaptic Input

6.6 Summary and Sources

6.7 Exercises

7 Fourier Series and Transforms

7.1 Fourier Series

7.2 The Discrete Fourier Transform

7.3 The Fourier Transform

7.4 Reconciling the Discrete and Continuous Fourier Transforms

7.5 Summary and Sources

7.6 Exercises

8 The Passive Dendritic Tree

8.1 The Discrete Passive Tree

8.2 Eigenvector Expansion

8.3 Numerical Methods

8.4 The Passive Dendrite Equation

8.5 The Equivalent Cylinder*

8.6 Branched Eigenfunctions*

8.7 Summary and Sources

8.8 Exercises

9 The Active Dendritic Tree

9.1 The Active Uniform Cable

9.2 On the Interaction of Active Uniform Cables*

9.3 The Active Nonuniform Cable

9.4 The Quasi-Active Cable*

9.5 The Active Dendritic Tree

9.6 Summary and Sources

9.7 Exercises

10 Extracellular Potential

10.1 Maxwell's Equations

10.2 The Wave Equation

10.3 From Maxwell to Laplace

10.4 The Solution to Laplace's Equation

10.5 Extracellular Potential Near a Passive Cable

10.6 Extracellular Potential Near Active Cables

10.7 Summary and Sources

10.8 Exercises

11 Reduced Single Neuron Models

11.1 The Leaky Integrate-and-Fire Neuron

11.2 Bursting Neurons

11.3 Simplified Models of Bursting Neurons

11.4 Summary and Sources

11.5 Exercises

12 Probability and Random Variables

12.1 Events and Random Variables

12.2 Binomial Random Variables

12.3 Poisson Random Variables

12.4 Gaussian Random Variables

12.5 Cumulative Distribution Functions

12.6 Conditional Probabilities*

12.7 Sum of Independent Random Variables*

12.8 Transformation of Random Variables*

12.9 Random Vectors*

12.10 Exponential and Gamma Distributed Random Variables

12.11 The Homogeneous Poisson Process

12.12 Summary and Sources

12.13 Exercises

13 Synaptic Transmission and Quantal Release

13.1 Basic Synaptic Structure and Physiology

13.2 Discovery of Quantal Release

13.3 Compound Poisson Model of Synaptic Release

13.4 Comparison with Experimental Data

13.5 Quantal Analysis at Central Synapses

13.6 Facilitation, Potentiation and Depression of Synaptic Transmission

13.7 Models of Short-Term Synaptic Plasticity

13.8 Summary and Sources

13.9 Exercises

14 Neuronal Calcium Signaling*

14.1 Voltage Gated Calcium Channels

14.2 Diffusion, Buffering and Extraction of Cytosolic Calcium

14.3 Calcium Release from the Endoplasmic Reticulum

14.4 Regulation of Calcium in Spines

14.5 Spinal Calcium and Bidirectional Synaptic Plasticity

14.6 Presynaptic Calcium and Transmitter Release

14.7 Summary and Sources

14.8 Exercises

15 Neurovascular Coupling, the BOLD Signal and MRI

15.1 The Metabolic Cost of Neural Signaling

15.2 Astrocytes

15.3 Smooth Muscle

15.4 Endothelium

15.5 The Neurovascular Unit

15.6 How Blood Distorts an Applied Magnetic Field

15.7 Nuclear Magnetic Resonance and the BOLD Signal

15.8 The Hemodynamic Response

15.9 Magnetic Resonance Imaging

15.10 Summary and Sources

15.11 Exercises

16 The Singular Value Decomposition and Applications*

16.1 The Singular Value Decomposition

16.2 Principal Component Analysis and Spike Sorting

16.3 Synaptic Plasticity and Principal Components

16.4 Neuronal Model Reduction via Balanced Truncation

16.5 Summary and Sources

16.6 Exercises

17 Quantification of Spike Train Variability

17.1 Interspike Interval Histograms and Coefficient of Variation

17.2 Refractory Period

17.3 Spike Count Distribution and Fano Factor

17.4 Renewal Processes

17.5 Return Maps and Serial Correlation Coefficients

17.6 Summary and Sources

17.7 Exercises

18 Stochastic Processes

18.1 Definition and General Properties

18.2 Gaussian Processes

18.3 Point Processes

18.4 The Inhomogeneous Poisson Process

18.5 Spectral Analysis

18.6 Summary and Sources

18.7 Exercises

19 Membrane Noise*

19.1 Two-State Channel Model

19.2 Multi-State Channel Models

19.3 The Ornstein-Uhlenbeck Process

19.4 Synaptic Noise

19.5 Summary and Sources

19.6 Exercises

20 Power and Cross-Spectra

20.1 Cross-Correlation and Coherence

20.2 Estimator Bias and Variance

20.3 Numerical Estimate of the Power Spectrum*

20.4 Summary and Sources

20.5 Exercises

21 Natural Light Signals and Phototransduction

21.1 Wavelength and Intensity

21.2 Spatial Properties of Natural Light Signals

21.3 Temporal Properties of Natural Light Signals

21.4 A Model of Phototransduction

21.5 Summary and Sources

21.6 Exercises

22 Firing Rate Codes and Early Vision

22.1 Definition of Mean Instantaneous Firing Rate

22.2 Visual System and Visual Stimuli

22.3 Spatial Receptive Field of Retinal Ganglion Cells

22.4 Characterization of Receptive Field Structure

22.5 Spatio-Temporal Receptive Fields

22.6 Static Non-Linearities*

22.7 Summary and Sources

22.8 Exercises

23 Models of Simple and Complex Cells

23.1 Simple Cell Models

23.2 Non-Separable Receptive Fields

23.3 Receptive Fields of Complex Cells

23.4 Motion-Energy Model

23.5 Hubel-Wiesel Model

23.6 Multiscale Representation of Visual Information

23.7 Summary and Sources

23.8 Exercises

24 Models of Motion Detection

24.1 HRC Model of Motion Detection

24.2 Responses to Moving Stimuli

24.3 Properties of the Correlation Model

24.4 Equivalence with the Motion-Energy Model

24.5 Beyond Correlation in Motion Detection

24.6 Summary and Sources

24.7 Exercises

25 Stochastic Estimation Theory

25.1 Minimum Mean-Square Error Estimation

25.2 Estimation of Gaussian Signals*

25.3 Linear Non-Linear (LN) Models*

25.4 Summary and Sources

25.5 Exercises

26 Reverse-Correlation and Spike Train Decoding

26.1 Reverse-Correlation

26.2 Stimulus Reconstruction

26.3 Summary and Sources

26.4 Exercises

27 Signal Detection Theory

27.1 Testing Hypotheses

27.2 Ideal Decision Rules

27.3 ROC Curves*

27.4 Multi-Dimensional Gaussian Signals*

27.5 Fisher Linear Discriminant*

27.6 Summary and Sources

27.7 Exercises

28 Relating Neuronal Responses and Psychophysics

28.1 Single Photon Detection

28.2 Signal Detection Theory and Psychophysics

28.3 Motion Detection

28.4 Summary and Sources

28.5 Exercises

29 Population Codes*

29.1 Cartesian Coordinate Systems

29.2 Overcomplete Representations

29.3 Frames

29.4 Maximum Likelihood

29.5 Estimation Error and Cramer-Rao Bound*

29.6 Population Coding in the Superior Colliculus

29.7 Summary and Sources

29.8 Exercises

30 Neuronal Networks

30.1 Perceptrons

30.2 Hopfield Networks

30.3 Integrate and Fire Networks

30.4 Integrate and Fire Networks with Plastic Synapses

30.5 Formation of the Grid Cell Network via STDP

30.6 Hodgkin-Huxley Based Networks

30.7 Hodgkin-Huxley Based Networks with Plastic Synapses

30.8 Rate Based Networks

30.9 Brain Maps and Self-Organizing Maps

30.10 Summary and Sources

30.11 Exercises

31 Solutions to Exercises

31.1 Chapter 2

31.2 Chapter 3

31.3 Chapter 4

31.4 Chapter 5

31.5 Chapter 6

31.6 Chapter 7

31.7 Chapter 8

31.8 Chapter 9

31.9 Chapter 10

31.10 Chapter 11

31.11 Chapter 12

31.12 Chapter 13

31.13 Chapter 14

31.14 Chapter 15

31.15 Chapter 16

31.16 Chapter 17

31.17 Chapter 18

31.18 Chapter 19

31.19 Chapter 20

31.20 Chapter 21

31.21 Chapter 22

31.22 Chapter 23

31.23 Chapter 24

31.24 Chapter 25

31.25 Chapter 26

31.26 Chapter 27

31.27 Chapter 28

31.28 Chapter 29

31.29 Chapter 30

Bibliography

Index

Back Cover

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