Description
Stress and Epigenetics in Suicidediscusses the central role of epigenetic modifications in suicidal behavior. As early-life stress and an individual's ability to cope with such stressors, combined with psychological factors, social factors, and existential and cognitive factors can predispose young people to suicidal behavior and put them at added risk of suicidal behavior later in life, this book provides readers with an overview of the neurobiology of stress, an introduction to the epigenetic changes induced by stress, and an understanding of how vulnerability and resilience to stress are built.
It integrates these mechanisms into a biobehavioral model of suicide based on epigenetic marks, gene-environment interactions, and other stressors. More importantly, it provides future direction for research and discusses potential interventions.
This book is an ideal and trusted resource for researchers and clinicians who are interested in learning how the environment can affect behavior through genetics, and for those seeking the development of new methods for suicide prevention.
- Explores the neurobiology of stress and stress-related epigenetics, including discussion of the role of stress-induced epigenetic changes in behavioral, emotional, and cognitive mechanisms and whether these epigenetic marks are transgenerational
- Provides compelling biobehavioral models of suicide based on genetics, epigenetics, and behavioral adjustment
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Chapter
Suicide among young people in the European continent
Children and adolescent suicides in the countries of the former USSR
Youth suicides in Asia and the Far East
Situation in North America, Australia, and New Zealand
Suicide among young people in Latin America and Africa
Youth is under threat—preliminary conclusions
Youth mental health problems—are they growing too?
Subjective complaints in adolescents and values shift as signs of stress
Chapter 2 - Neurobiology of Stress—From Homeostasis to Allostasis and How Social Environment is Involved
Psychosocial stress and modernization
Neuroendocrinology of stress response—how psychosocial stress affects health
From homeostasis to allostasis and how social environment is involved
Stress and the brain—mental health consequences
Stress across the life-span and social factors
Chapter 3 - What Is Epigenetics? Is It Transgenerational?
Epigenetics—new life of old ideas and modern definitions
Molecular mechanisms of epigenetics and epigenetic inheritance—a short review
Epigenetics and ontogenetic programming
Epigenetic events in preembryonic and early embryonic development
Nutrition, body growth, and epigenetics of older age diseases
Epigenetics of ecological hazards, in aging and cancer
Epigenetic paradigm and evolutionary biology
Chapter 4 - Biological Embedding—How Early Life Stress Shapes Behaviors Later in Life and How Vulnerability is Built
Early life stress and behavioral epigenetics—animal models
Early life stress and epigenetic programming of behavior and mental health in humans
Life-time stress experiences and epigenetics
Biological embedding—how social environment “gets under the skin”
Chapter 5 - Interactions and Integrations—Biobehavioral Model of Suicide Based on Genetics, Epigenetics, and Behavioral Adjustment
Theories and models of suicidal behavior—how they encounter stress
Heritability of suicide—classical behavioral genetics studies
Suicide genetics—genes-to-environment interactions and vulnerable phenotypes
Epigenetic findings in suicide
Biobehavioral-psychological-existential model of suicide
Chapter 6 - Ideas for Prevention
Conceptual framework and prevention strategies limitations
How resilience is built? The earlier—the better
Adolescents’ resilience—the power of body and mind
Adolescents’ resilience—the power of meaning