Stress and Epigenetics in Suicide

Author: Rozanov   Vsevolod  

Publisher: Elsevier Science‎

Publication year: 2017

E-ISBN: 9780128052860

P-ISBN(Paperback): 9780128051993

Subject: B845 生理心理学;Q189 Neurobiology;R58 Endocrine disease and metabolic disease

Keyword: 神经病学与精神病学

Language: ENG

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Description

Stress and Epigenetics in Suicidediscusses the central role of epigenetic modifications in suicidal behavior. As early-life stress and an individual's ability to cope with such stressors, combined with psychological factors, social factors, and existential and cognitive factors can predispose young people to suicidal behavior and put them at added risk of suicidal behavior later in life, this book provides readers with an overview of the neurobiology of stress, an introduction to the epigenetic changes induced by stress, and an understanding of how vulnerability and resilience to stress are built.

It integrates these mechanisms into a biobehavioral model of suicide based on epigenetic marks, gene-environment interactions, and other stressors. More importantly, it provides future direction for research and discusses potential interventions.

This book is an ideal and trusted resource for researchers and clinicians who are interested in learning how the environment can affect behavior through genetics, and for those seeking the development of new methods for suicide prevention.

  • Explores the neurobiology of stress and stress-related epigenetics, including discussion of the role of stress-induced epigenetic changes in behavioral, emotional, and cognitive mechanisms and whether these epigenetic marks are transgenerational
  • Provides compelling biobehavioral models of suicide based on genetics, epigenetics, and behavioral adjustment

Chapter

Suicide among young people in the European continent

Children and adolescent suicides in the countries of the former USSR

Youth suicides in Asia and the Far East

Situation in North America, Australia, and New Zealand

Suicide among young people in Latin America and Africa

Youth is under threat—preliminary conclusions

Youth mental health problems—are they growing too?

Subjective complaints in adolescents and values shift as signs of stress

References

Chapter 2 - Neurobiology of Stress—From Homeostasis to Allostasis and How Social Environment is Involved

Psychosocial stress and modernization

Neuroendocrinology of stress response—how psychosocial stress affects health

From homeostasis to allostasis and how social environment is involved

Stress and the brain—mental health consequences

Stress across the life-span and social factors

References

Chapter 3 - What Is Epigenetics? Is It Transgenerational?

Epigenetics—new life of old ideas and modern definitions

Molecular mechanisms of epigenetics and epigenetic inheritance—a short review

Epigenetics and ontogenetic programming

Epigenetic events in preembryonic and early embryonic development

Nutrition, body growth, and epigenetics of older age diseases

Epigenetics of ecological hazards, in aging and cancer

Epigenetic paradigm and evolutionary biology

References

Chapter 4 - Biological Embedding—How Early Life Stress Shapes Behaviors Later in Life and How Vulnerability is Built

Early life stress and behavioral epigenetics—animal models

Early life stress and epigenetic programming of behavior and mental health in humans

Life-time stress experiences and epigenetics

Biological embedding—how social environment “gets under the skin”

References

Chapter 5 - Interactions and Integrations—Biobehavioral Model of Suicide Based on Genetics, Epigenetics, and Behavioral Adjustment

Theories and models of suicidal behavior—how they encounter stress

Heritability of suicide—classical behavioral genetics studies

Suicide genetics—genes-to-environment interactions and vulnerable phenotypes

Epigenetic findings in suicide

Biobehavioral-psychological-existential model of suicide

References

Chapter 6 - Ideas for Prevention

Conceptual framework and prevention strategies limitations

How resilience is built? The earlier—the better

Adolescents’ resilience—the power of body and mind

Adolescents’ resilience—the power of meaning

References

Conclusions

Index

Back Cover

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