Imidazo[1,2-a]pyridines: Promising Drug Candidate for Antitumor Therapy

Publisher: Bentham Science Publishers

E-ISSN: 1873-4294|16|30|3590-3616

ISSN: 1568-0266

Source: Current Topics in Medicinal Chemistry, Vol.16, Iss.30, 2016-10, pp. : 3590-3616

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Abstract

Imidazo[1,2-a]pyridine has been shown to be an important biologically active moiety. Thisreview is a compilation of the scattered output of results of the anticancer activities of the imidazo[1,2-a]pyridine system since 2001, which have been classified as inhibition of CDK, VEGFR,PI3K, EGFR, RGGT etc. along with inhibition against different tumor cell lines. Various imidazo[1,2-a]pyridine based analogues have been used as lead molecules and are now under humanclinical trials. This review will help the wider scientific community in the area of drug discovery ofimidazo[1,2-a]pyridines as novel anticancer agents.