Nitric Oxide and the Cell ：Proliferation, Differentiation, and Death ( Princeton Legacy Library )

Publication subTitle ：Proliferation, Differentiation, and Death

Publication series ：Princeton Legacy Library

Author： Moncada S.;Nisticò G.;Bagetta G.

Publisher： Princeton University Press‎

Publication year： 2017

E-ISBN: 9781400887538

P-ISBN(Paperback): 9780691007168

Subject： Q5 Biochemistry

Keyword：生物化学

Language： ENG

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Description

Nitric oxide has proven to be a molecule with wide biological significance. It is involved in myriad actions which range from physiology to pathophysiology. One of the fundamental questions in relation to its biological relevance concerns the paradoxical nature of some of its actions. For example, there is a whole range of effects related to cytoprotection, cell proliferation, differentiation, and cell death. The way in which nitric oxide becomes involved in pathophysiology is slowly being elucidated. This volume contains a summary of the discussions that took place at the Second International Paraelios Symposium on Nitric Oxide research, and will make a significant contribution to this very exciting subject.

Originally published in 1998.

The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Chapter

1. Nitric oxide, mitochondria and cytotoxicity

2. Nitric oxide and its congeners in mitochondria: implications for apoptosis

3. Interactions between nitric oxide and cytochrome-c oxidase in turnover

4. Nitric oxide interactions with mitochondria and oxygen metabolism

5. Resistance factors for nitorsative and oxidative stress

6. S-Nitrosylation of thiol groups in haemoglobins from various species

7. Differential inhibitory action of nitric oxide and peroxynititre on the R2 subunit of ribonucleotide reductase

8. Hydroxyguanidines as modifiers of cell proliferation and death: a possible role for nitric oxide

9. Control of cell growth by nitric oxide: the role of cGMP-dependent and -independent events occuring at various steps of growth factor-activated signalling processes

10. Nitric oxide controls cell proliferation during Drosophila development

11. Cytoprotective actions of nitric oxide in hepatic inflammation

12. Activation of nuclear factor-kB and activator protein-I, and steady-state level of mRNA encoding tumour necrosis factor-a and inducible nitric oxide synthase in rate liver during different types of cell proliferation

13. The mechanism of nitric oxide-induced apoptosis in the pancreatic B-cell may involve cGMP and protein kinase G

14. Normal and pathological expression of nitric oxide synthase in the central nervous system

15. The role of astroglial cell-derived nitric oxide and prostanoids in death and repair mechanisms in the brain

16. Role of nitric oxide and nerve growth factor in the mechanisms of neurotoxicity induced by the HIV-I coat protein gp 120 in rat

17. Mechanisms of neurotoxicity induced by the HIV-I coat protein, gp 120, in human neuroblastoma cells in culture

18. Nitric oxide mediates differentiation and survival of neuronal cells

19. Neuromodulatory and neuroprotective actions of nitric oxide in the striatum

20. Microdialysis study in vivo of the nitric oxide/cGMP pathway in the hippocampus and cerebellum of adult and aged rats

21. Mechanisms of neuronal apoptosis elicited by glutamate or nitric oxide donors

22. Evidence that nitric oxide induces apoptotic cell death in the lateral geniculate nucleus of dark-reared rabbits

23. Nitric oxide and prostaglandins in inflammation

24. A further insight into mechanism of lipoxygenase inhibition by nitric oxide

25. The role of nitric oxide in T-cell functions

26. CD95-induced calcium release and apoptosis are regulated by nitric oxide via a cGMP-dependent pathway in human yg T-lymphocytes

27. Nitric oxide-initiated apoptotic cell death: activating and antagonistic signalling components

28. Nitric oxide-induced apoptosis of RAW264.7 peritoneal macrophages: relationship between apoptosis and integrin expression profiles

29. Nitric oxide, p53 and cancer

30. The role of nitric oxide in Bacillus Calmette-Guerin-mediated anti-tumour effects in human bladder cancer

31. Nitric oxide priming inhibits nitric oxide-mediated apoptosis

Subject Index

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