Cancer in Pregnancy :Maternal and Fetal Risks

Publication subTitle :Maternal and Fetal Risks

Author: G. Koren; M. Lishner; D. Farine  

Publisher: Cambridge University Press‎

Publication year: 1996

E-ISBN: 9780511886362

P-ISBN(Paperback): 9780521471763

Subject: R714.259 Other

Keyword: 肿瘤学

Language: ENG

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Cancer in Pregnancy

Description

Cancer in pregnancy, although thankfully a relatively uncommon occurrence, presents physicians and their patients with a major dilemma. The urge to use the highest tolerable doses of chemotherapy, high doses of irradiation and surgery has to be weighed carefully against their risks to the unborn baby. This book is the very first to attempt to quantify these risks and provide physicians with a core of knowledge that will be very relevant to making sound clinical decisions in the face of sometimes conflicting interests. The volume evaluates the results of the Motherisk Program, which was set up specifically to address this problem, and reviews maternal and fetal outcomes from a sizeable database of the most common cases of cancer in pregnancy. In reviewing this program and the experience of others in this area, this volume sets out to create a clinically relevant tool for oncologists, obstetrician-gynecologists, perinatologists and neonatologists.

Chapter

2 The pregnant patient with malignant disease:Maternal-fetal conflict

Introduction

Incidence

Issues complicating the management of malignancy in the pregnant patient

Ethical issues

Legal aspects

The effects of pregnancy on tumor

The effects of tumor on pregnancy

The optimal time of delivery

Summary: general guidelines for management

References

3 Changes in drug disposition during pregnancyand their clinical implications

Introduction

Pharmacokinetics of the maternal-fetal unit

Clinical implications

Summary

References

4 The role of the placenta in thebiotransformation of carcinogenic compounds

Introduction

Summary and conclusion

References

5 Antepartum fetal monitoring in the oncologicpatient

Introduction

Biochemical parameters

NST (nonstress test)

CST (contraction stress test)

Ultrasound

The fetal biophysical profile

Doppler ultrasound

References

6 The Toronto Study Group: methodologicalnotes

References

7 Motherisk: the process of counselling inreproductive toxicology

Introduction

Inception

Mandate

Telephone information service

Telephone follow-up

Clinic consultation

Follow-up of pregnancy outcome

Technical support

Staff

Educational component

Suppor

Motherisk satellites

Summary

Part II Specific tumors during pregnancy

8 Maternal and fetal outcome following breastcancer in pregnancy

Methods

Results

Fetal outcome

Discussion

References

9 Maternal and fetal outcome followingHodgkin's disease in pregnancy

Introduction

Methods

Results

Maternal outcome

Pregnancy outcome

Discussion

References

10 Non-Hodgkin's lymphoma and pregnancy

References

11 Maternal and fetal outcome following invasivecervical cancer in pregnancy

Introduction

Methods

Results

Fetal outcome

Discussion

References

12 Pregnancy and ovarian cancer

References

13 Malignant melanoma and pregnancy

References

14 Leukemia during pregnancy

References

15 Thyroid cancer and pregnancy

Introduction

Changes in thyroid status with pregnancy

Thyroid cancer in pregnancy

Thyroid cancer management

Conclusions

Acknowledgements

References

Part III Fetal effects of cancer and its treatment

16 Prenatal irradiation and cancer

Summary

References

17 Review of fetal effects of cancerchemotherapeutic agents

The cell cycle

Alkylating agents

Vinca alkaloids

Antibiotics

Combination chemotherapy

Other toxic effects

Summary

References

18 Fetal outcome following in utero exposure tocancer chemotherapy: the Toronto Study

Methods

Results

Discussion

References

19 Intrauterine causes of tumors in later life

Diethylstilbestrol (DES)

Intrauterine exposure to phenytoin and the occurrence of neuroblastoma

In vitro lymphocyte toxicity assay

References

20 Fetal tumors

Teratoma

Sacrococcgeal teratoma

Neck and craniofacial teratomas

The chest

The abdomen and pelvis

The kidney and adrenal glands

The ovary

Fetal metastasis of maternal tumors

Conclusion

References

Index

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