Lymphoma: Pathology, Diagnosis and Treatment

Author: Robert Marcus; John W. Sweetenham; Michael E. Williams  

Publisher: Cambridge University Press‎

Publication year: 2007

E-ISBN: 9780511889363

P-ISBN(Paperback): 9780521865449

Subject: R55 Blood and lymphatic system disorders

Keyword: 血液及淋巴系疾病

Language: ENG

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Lymphoma: Pathology, Diagnosis and Treatment

Description

Major advances have occurred in almost every aspect of the diagnosis and treatment of lymphoma in recent years. Our understanding of the molecular biology and genetics of the disease has increased exponentially, and significant developments in imaging of this malignancy have resulted in earlier and more accurate diagnosis. At the same time, advances in therapeutic immunology have led to the development of several new treatment options. This landmark new text describes these advances in a single concise volume, placing them in the context of daily clinical practice. Introductory chapters review epidemiology, prognostic factors, imaging and therapeutic immunology. These are followed by chapters on each lymphoma subtype, dealing comprehensively with all aspects of the diagnosis and treatment of the disorder. Highly illustrated in full colour throughout and written and edited by the leading authorities in the field, this book provides all the information needed to diagnose and manage these complex disorders.

Chapter

3 IMAGING

INTRODUCTION

STAGING TECHNIQUES

STAGING CLASSIFICATIONS

RESPONSE ASSESSMENT

COMPLICATIONS OF THERAPY

4 PROGNOSTIC FACTORS FOR LYMPHOMAS

INTRODUCTION

METHODOLOGY FOR BUILDING PROGNOSTIC INDICES

DIFFUSE LARGE B-CELL LYMPHOMA

FOLLICULAR LYMPHOMAS

MANTLE CELL LYMPHOMAS

PERIPHERAL T-CELL LYMPHOMAS

MARGINAL ZONE LYMPHOMAS

BURKITT’S LYMPHOMA

PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA

HODGKIN’S LYMPHOMA

5 CLINICAL TRIALS IN LYMPHOMA

INTRODUCTION

BACKGROUND

INFORMED CONSENT

ENDPOINTS

OUTCOME DATA

EVALUATING TREATMENT EFFECT

PRECISION AND ERROR CONTROL

PHASE I TRIALS

PHASE II TRIALS

RANDOMIZED PHASE II TRIALS

PHASE III TRIALS

CONCLUSION

6 THERAPEUTIC IMMUNOLOGY

INTRODUCTION

TUMOR ANTIGENS

MONOCLONAL ANTIBODIES

THERAPEUTIC ANTI-CANCER VACCINES

ACTIVE VACCINATION APPROACHES AGAINST NON-HODGKIN’S LYMPHOMA

FUTURE PROSPECTS FOR IMMUNO THERAPEUTICAPPROACHES DIRECTED AT HEMATOLOGIC MALIGNANCIES

Part II LYMPHOMA SUBTYPES

7 HODGKIN’S LYMPHOMA

INTRODUCTION

EPIDEMIOLOGY

CLINICAL PRESENTATION

DIAGNOSIS

PATHOLOGY

MOLECULAR PATHOLOGY AND CYTOGENETICS

STAGING AND RISK STRATIFICATION

FIRST-LINE TREATMENT

TREATMENT OF PRIMARY PROGRESSIVE AND RELAPSED HODGKIN’S LYMPHOMA

TARGETED THERAPY OF HODGKIN’S LYMPHOMA

TREATMENT OF LYMPHOCYTE PREDOMINANTHODGKIN’S LYMPHOMA (NLPHL)

TREATMENT OF HODGKIN’S LYMPHOMA IN CHILDREN AND ADOLESCENTS

THERAPY-ASSOCIATED TOXICITY

SUMMARY

8 FOLLICULAR LYMPHOMA

INTRODUCTION

CLINICAL PRESENTATION

PATHOLOGY

MOLECULAR PATHOLOGY AND CYTOGENETICS

STAGING INVESTIGATIONS

PROGNOSTIC FACTORS

TREATMENT OF EARLY-STAGE DISEASE

TREATMENT OF ADVANCED DISEASE IN ASYMPTOMATIC PATIENTS

FIRST-LINE TREATMENT OF ADVANCED DISEASE IN SYMPTOMATIC PATIENTS

MANAGEMENT OF RELAPSED FOLLICULAR LYMPHOMA

9 MALT LYMPHOMA AND OTHER MARGINAL ZONE LYMPHOMAS

EXTRANODAL MARGINAL ZONE B-CELL LYMPHOMA (MALT LYMPHOMA): CLINICAL FEATURES

MALT LYMPHOMA: PATHOLOGY

MALT LYMPHOMA: MOLECULAR PATHOLOGY AND CYTOGENETICS

MALT LYMPHOMA: STAGING

MALT LYMPHOMA: MANAGEMENT AND FOLLOW-UP

IMMUNOPROLIFERATIVE SMALL INTESTINAL DISEASE (IPSID)

PRIMARY SPLENIC MARGINAL ZONE LYMPHOMA

NODAL MARGINAL ZONE LYMPHOMA

10 SMALL LYMPHOCYTIC LYMPHOMA AND ITS VARIANTS

INTRODUCTION

PATHOLOGY

MOLECULAR PATHOLOGY AND CYTOGENETICS

THERAPY

CONCLUSION

11 MANTLE CELL LYMPHOMA

INTRODUCTION

CLINICAL PRESENTATION

PATHOLOGY

MOLECULAR PATHOLOGY AND CYTOGENETICS

STAGING

PROGNOSTIC FACTORS

FIRST-LINE THERAPY

CONSOLIDATION AND MAINTENANCE THERAPY

ALLOGENEIC STEM-CELL TRANSPLANTATION

MANAGEMENT OF RELAPSED DISEASE

NOVEL THERAPEUTIC APPROACHES

FUTURE DIRECTIONS

12 DIFFUSE LARGE B-CELL LYMPHOMA

INTRODUCTION

CLINICAL PRESENTATION

PATHOLOGY

MOLECULAR PATHOLOGY AND CYTOGENETICS

STAGING INVESTIGATIONS

PROGNOSTIC FACTORS

TREATMENT OF EARLY-STAGE DLBCL

TREATMENT OF ADVANCED-STAGE DLBCL

MANAGEMENT OF RELAPSED DLBCL

NEW THERAPEUTIC TARGETS IN DLBCL

13 BURKITT’S AND LYMPHOBLASTIC LYMPHOMAS

INTRODUCTION AND PRESENTATION

PATHOLOGY

MOLECULAR PATHOLOGY AND CYTOGENETICS

STAGING

TREATMENT PRINCIPLES FOR BURKITT’S LYMPHOMA

TREATMENT OF BURKITT’S LYMPHOMA

MANAGEMENT OF RELAPSED BURKITT’S LYMPHOMA

HIV-ASSOCIATED BURKITT’S LYMPHOMA

TREATMENT RECOMMENDATIONS IN BURKITT’S LYMPHOMA

TREATMENT PRINCIPLES FOR LYMPHOBLASTIC LYMPHOMA

TREATMENT OF LYMPHOBLASTIC LYMPHOMA

CNS TREATMENT OF LYMPHOBLASTIC LYMPHOMA

MANAGEMENT OF RELAPSED LYMPHOBLASTIC LYMPHOMA

TREATMENT RECOMMENDATIONS FOR LYMPHOBLASTIC LYMPHOMA

SUPPORTIVE CARE OF BURKITT’S AND LYMPHOBLASTIC LYMPHOMA

14 CENTRAL NERVOUS SYSTEM LYMPHOMA

INTRODUCTION

PATHOLOGY

MOLECULAR PATHOLOGY AND CYTOGENETICS

PRIMARY CNS LYMPHOMAS

SECONDARY CNS LYMPHOMAS

RARE FORMS OF CNS LYMPHOMA

15 T-CELL LYMPHOMA

INTRODUCTION

ETIOLOGY

PROGNOSIS

SPECIFIC DISEASE TYPES

STEM-CELL TRANSPLANTATION

RADIATION THERAPY

EMERGING THERAPIES

16 CUTANEOUS LYMPHOMA

INTRODUCTION

PRIMARY CUTANEOUS T-CELL LYMPHOMAS (CTCL)

CD30-POSITIVE T-CELL LYMPHOPROLIFERATIVE DISORDERS OF THE SKIN

SUBCUTANEOUS PANNICULITIS-LIKE T-CELL LYMPHOMA

PRIMARY CUTANEOUS PERIPHERAL T-CELL LYMPHOMA, UNSPECIFIED

PRIMARY CUTANEOUS B-CELL LYMPHOMAS (CBCL)

17 LYMPHOMA IN THE IMMUNOSUPPRESSED

INTRODUCTION

PATHOLOGY

MOLECULAR PATHOLOGY AND CYTOGENETICS

CLINICAL PRESENTATION AND INVESTIGATIONS

POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDERS

HIV-ASSOCIATED LYMPHOMAS

INDEX

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