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Contents

Preface

The ‘Gastric Cytoprotection’ Concept of Andre Robert and the Origins of a New Series of International Symposia

Abstract

Evolution of the Concept of Gastric Cytoprotection

Origins and Development of Related International Symposia

Acknowledgements

References

Importance of Translational Research in GI Pharmacology: Lessons Learned from the Successes in History

Abstract

Translational Research in Medicine

Lesson No. 1: Gastric Acid Secretion

Lesson No. 2: Brain-Gut Axis

Lesson No. 3: Gastric Acid Inhibitors

Lesson No. 4: Helicobacter pylori

Future Perspectives

References

Acetic Acid Ulcer Model – State ofthe Art in 2012

Abstract

Mechanism of Ulcer Healing

New Substances Promising for Ulcer Treatment

Chemical Removal of a Gastric Cancer Model by Acetic Acid Ulcer

References

Roles of EP4 Receptors in Protective and Healing-Promoting Effects of Prostaglandin E2 on NSAID-Induced Small Intestinal Damage

Abstract

Pathogenic Mechanisms of NSAID-Induced Small Intestinal Damage

Protective Effect of PGE2 on NSAID- Induced Small Intestinal Damage

Functional Alterations Related to the Small Intestinal Protection by PGE2

Healing of NSAID-Induced Small Intestinal Damage

Healing-Promoting Effect of PGE2 on NSAID-Induced Small Intestinal Damage

Conclusion

Acknowledgements

References

Role of Food and Enterobacteria in the Formation and Prevention of Small Intestinal Damage Induced by NSAIDs

Abstract

Role of Food

Role of Enterobacteria

References

Synergic Effect of NSAID and Gastric Acid on Superoxide-Anion Production in Stomach

Abstract

Mucosal Defense Mechanisms

Synergic Effects of both NSAID and Acidic Conditions

Mitochondria as a Target of Oxidative Stress

Conclusion

References

Development of NSAIDs with Lower Gastric Side Effect

Abstract

Results and Discussion

Conclusion

References

NSAID-Mucosal Injury: Roles of Drug Chemistry in Pathogenesis

Abstract

Ion Trapping, pKa, Lipophilicity and Mucosal Injury

Conclusions

References

Animal Model for Evaluating Gastric Bleeding and Ulcerogenic Response Induced by Aspirin plus Clopidogrel

Abstract

Experimental Model of Gastric Bleeding

Determination of Hemoglobin Concentrations

Gastric Ulcerogenic and Bleeding Responses to Acidified ASA with or without Clopidogrel Pretreatment

Effect of Various Antiulcer Drugs on Gastric Bleeding and Ulcerogenic Responses to Acidified ASA plus Clopidogrel

Commentary

Conclusion

References

Effects of Ibuprofen, and Some Analogues, on the Muscle Tone of Isolated Segments of the Common Digital Artery of the Fallow Deer (Dama dama)

Abstract

Methods

Results and Discussion

Acknowledgements

References

Psychological Stress Induces Visceral Analgesic or Hyperalgesic Response in Rodents: A Role of Preconditions

Abstract

Psychological Stressors in Rodent Models

Monitoring Visceral Pain Response

Mechanisms of Stress-Induced Visceral Hypersensitivity

Sexual Dimorphism in Mechanisms of Stress- Induced Visceral Analgesia

Modulation of Stress Influence by Probiotics

Clinical Significance: Implications in Irritable Bowel Syndrome

Acknowledgments

References

Neurobiology of Corticotropin-Releasing Factor in the Enteric Nervous System during Stress

Abstract

Corticotropin-Releasing Factor Peptides in the Enteric Nervous System

Corticotropin-Releasing Factor Receptors in the Enteric Nervous System

Actions of Corticotropin-Releasing Factor in the Enteric Nervous System

Peripheral Corticotropin-Releasing Factor Signaling in Stress-Related Gastrointestinal Dysmotility

Peripheral Corticotropin-Releasing Factor Signaling in Stress-Related Mucosal Dysfunction

Involvement of the Enteric Nervous System in the Colonic Response to Stress

Conclusion

References

Corticotropin-Releasing Factor May Protect the Gastric Mucosa in Stress through Involvement of Glucocorticoids

Abstract

HPA Axis Activation as a Gastroprotective Component of Stress Response

Corticotropin-Releasing Factor and Gastric Ulceration

Gastroprotective Role of CRF: Involvement of Glucocorticoids

Conclusion

Acknowledgements

References

Pathogenic Potential of Psychogenic Stress in Gastric Mucosal Injury

Abstract

Contractile Activity of the Gastroduodenal Zone under Psychogenic Stress in Rabbits

Pathogenic Role of Stress-Induced Gastroduodenal Dysmotility

References

Advances in Understanding Inflammation in Esophageal Disease

Abstract

Conclusion

References

Physiopathology of Esophageal Inflammation, Ulcerogenesis and Repair by Studying the Profile of Glycoconjugate

Abstract

A Historical Sketch

Screening Glycoconjugates in Esophageal Mucosa

Inflammation as a Common Mechanism of Esophageal Ulcerogenesis

Detection of Glucoconjugates in Esophageal Injuries

Conclusion

References

Analysis of the Effect of Different Neuropeptides in Gastric Mucosal Defense Initiated Centrally

Abstract

Gastroprotection, Cholinergic System

Gastroprotection, Adrenergic System

Conclusion

Ackowledgements

References

Sulforaphane Enhances Protection and Repair of Gastric Mucosa against Oxidative Stress via Nrf2-Dependent Mechanisms

Abstract

H. pylori Infection and NSAIDs as Oxidative Stressor to Human Gastric Mucosa

'Adaptive Cytoprotection’ of Gastric Mucosa in Response to Oxidative Stresses

Sulforaphane Affords ‘Adaptive Cytoprotection’ in Response to Oxidative Stress

Role of the nrf2 in Protection and Repair of Gastric Mucosa against Oxidative Stress in vitro

Dietary Sulforaphane- Rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis in H. pylori-Infected Mice

References

Involvement of Renin-Angiotensin System and Vasoactive Angiotensin-(1–7) Metabolite of Angiotensin II in Gastric Mucosal Injury and Gastroprotection

Abstract

Physiology of the Renin-Angiotensin System and Angiotensin Receptors

Importance of RAS in the Mechanism of Gastric Mucosal Integrity

Vasodilatory and Protective Activity of Ang-(1– 7), One of the Major Angiotensin Metabolites in the GI Tract

Acknowledgements

References

Effect of Pentadecapeptide BPC 157 on Gastrointestinal Tract

Abstract

Periodontitis

Esophagus

Stomach

Duodenum

Intestine

Liver

Pancreas

Mechanism Implications

Conclusion

References

Pathobiology of Gastric Carcinoids and Adenocarcinomas in Rodent Models and Patients: Studies of Gastrocystoplasty, Gender-Related Factors and Autophagy

Abstract

Acid Secretion and Development of ECLoma in the Bladder of Rats Subjected to Gastrocystoplasty

Unknown Gender- Related Factors in Control of the Gastrin-ECL Cells Axis

Impaired Life-Cycle of Secretory Vesicles and Autophagy in Gastric Carcinoids

Impaired Autophagy in Gastric Adenocarcinoma

Conclusions

Acknowledgements

References

Roles of the Hydrogen Sulfide/T-Type Calcium Channel System in Somatic and Visceral Pain Processing

Abstract

Roles of H2S in Processing of Somatic Pain Signals in Health and Disease

Roles of H2S in Processing of Visceral Pain Signals and in the Pathophysiology of Pancreatitis-Related Pain

Involvement of the Excitation of Sensory Neurons in the H2S-Induced Colonic Mucosal Cytoprotection

Conclusion and Future Perspective

References

Age-Dependent Role of Vasopressin inSusceptibility of Gastric Mucosa toIndomethacin-Induced Injury

Abstract

Gastric Ulcer

Effects of Vasopressin

Vasopressin and Gastric Ulcer

Details of Ulcer Development in Brattleboro Rats

Conclusions

Acknowledgements

References

From Mucosal Energy Metabolism to Capsaicin – Strategies for Understanding Mucosal Protection

Abstract

Clinical Pharmacological Studies in Patients with Duodenal Ulcer in 1960–1970

Biochemical Examinations to Mucosal Energy Metabolisms

Animal Observations

Human Observations

Approach of Capsaicin Action on Gastric Mucosa

References

Author Index

Subject Index

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