Description
Polycystic ovary syndrome (PCOS) is the most frequent disorder affecting women of reproductive age. Recent years have shown substantial advances in our understanding of the complex genetic, biochemical, metabolic, cardiovascular, and reproductive issues associated with PCOS. This book presents a comprehensive overview of recent clinical developments in identifying the phenotypic expression of women with PCOS resulting in a completely new recognition of its phenotypic variability. Metabolic and cardiovascular consequences of the syndrome are discussed in detail. Advances made in dealing with secondary forms of PCOS-like syndromes are presented as well as specific therapies of clinical manifestations and their outcomes. Additionally, a number of hot topics are included presenting genetic developments, endothelial causes leading to unfavorable outcomes, and novelties in therapeutic approaches dealing with metabolic and reproductive consequences.Covering phenotypic characteristics, diagnostic criteria, central pathophysiological mechanisms, metabolic, cardiovascular and reproductive aspects, and modern therapeutic approaches, this book is a useful tool for general practitioners, gynecologists, pediatricians, internists, endocrinologists, as well as cardiologists.
Chapter
Polycystic Ovary Syndrome: Definitions, Phenotypes and Diagnostic Approach
Definitions and Phenotypes
Prevalence of Phenotypes Based on Different Criteria
PCOS Phenotypes through Life Cycle
Common Problems with Respect to Criteria Used for PCOS Classification
Cardiovascular Risk, Metabolic and Hormonal Profile Comparison of Four Phenotypes of PCOS Based on the Rotterdam Criteria
Differential Diagnosis of PCOS
Diagnosing PCOS in Adolescence
Towards a Tailor-Made Approach to Different PCOS Phenotypes
Impact of Nutrition on PCOS Phenotypes and Metabolic/Hormonal Abnormalities – A Potential Role for Advanced Glycated End Products
Pathophysiology of Polycystic Ovary Syndrome: The Role of Hyperandrogenism
The Disordered Folliculogenesis
Is the Excess of AMH a Good Candidate for Explaining Anovulation?
Genetics of Polycystic Ovary Syndrome
Limitations Associated with Genetics Studies in PCOS
Candidate Gene Studies in PCOS
Genome-Wide Association Studies in the Context of PCOS
Obesity, Adipokines and Metabolic Syndrome in Polycystic Ovary Syndrome
Adipokines and Metabolic Syndrome in General Population
Adipokines and Metabolic Syndrome in General Population: Trying to Get a Full View
Adipokine Production in PCOS
Androgens and Adipokine Production in PCOS
Dyslipidemia and Oxidative Stress in PCOS
Lipid Changes in Women with PCOS
Oxidative Stress and PCOS
Therapeutic Modalities for Dyslipidemia and Oxidative Stress in PCOS
Cardiovascular Risk and Subclinical Cardiovascular Disease in Polycystic Ovary Syndrome
Epidemiology of Cardiovascular Disease in PCOS
Cardiovascular Risk Factors in PCOS
Subclinical Cardiovascular Disease in PCOS
Medical Interventions and Cardiovascular Risk in PCOS
Insulin Sensitizers in Polycystic Ovary Syndrome
The Rationale for Using Insulin Sensitizers in PCOS
Insulin-Sensitizing Agents
Metformin: Mechanisms of Action
Metformin: Clinical Effects
Metformin Pharmacokinetics
Metformin: Are the Effects Dose Dependent?
Metformin: Factors Involved in Predicting Response
Thiazolidinediones: Mechanisms of Action
Thiazolidinediones: Clinical Effects
Metformin and Thiazolidinediones in PCOS: Comparative Studies
PCOS and Severe Insulin Resistance: A Target for Thiazolidinediones?
Hirsutism – From Diagnosis to Use of Antiandrogens
Pathophysiology of Hirsutism
Clinical Evaluation and Differential Diagnosis of Hirsutism
Laboratory Evaluation of Hirsutism
Principles of Treatment in Women with Hirsutism
Combined Oral Contraceptives in Polycystic Ovary Syndrome – Indications and Cautions
Oral Contraceptive Pills: Are They All the Same?
Oral Contraceptive Pill Use and Related Cardiovascular Risk in General Population
Oral Contraceptive Pill Use and Carbohydrate Metabolism in General Population
The Need for Oral Contraceptive Pills in PCOS
Oral Contraceptive Pills and Cardiovascular Risk Factors in PCOS
Oral Contraceptive Pill Use and Future Risk of Diabetes in PCOS
Infertility Treatment in Polycystic Ovary Syndrome: Lifestyle Interventions, Medications and Surgery
Causes of Infertility in Patients with PCOS
Pharmacological Treatment for the Induction of Ovulation
Laparoscopic Ovarian Drilling
Endocrinopathies and Other Disorders Inducing a Polycystic Ovary Syndrome Phenotype
Disorders Associated with a PCOS Phenotype
Clinical, Biochemical and Radiological Diagnostic Confirmation of Secondary Causes of PCOS
Non-Classic Adrenal Hyperplasia due to the Deficiency of 21-Hydroxylase and Its Relation to Polycystic Ovarian Syndrome
Non-Classic Adrenal Hyperplasia Diagnosis along the Woman’s Ageing
Adrenal Androgens and PCOS
Differentiating Non-Classic Adrenal Hyperplasia and PCOS
The Different Types of Congenital Adrenal Hyperplasia
CYP21 Mutations Heterozygotic Carriers in PCOS
Cardiovascular Risk in Non-Classic Adrenal Hyperplasia
Fertility in Non-Classic Adrenal Hyperplasia
Polycystic Ovary Syndrome
( Frontiers of Hormone Research )
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