New Insights into Glomerulonephritis ( Contributions to Nephrology )

Publication series ： Contributions to Nephrology

Author： Chen N.

Publisher： S. Karger AG‎

Publication year： 2013

E-ISBN: 9783318023909

P-ISBN(Paperback): 9783318023893

Subject： R692.3 nephritis

Keyword：细胞生物学,病理学,泌尿科学（泌尿生殖系疾病）,内科学,医学免疫学

Language： ENG

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Description

Chronic kidney disease is a global major health issue that ultimately leads to end-stage renal disease, a devastating condition requiring costly renal replacement therapy. Given this background, extensive understanding of the pathogenesis of the disease and exploring novel therapeutic targets will help to alleviate disease progression, improve prognosis and reduce its impact on the global economic burden.Currently, primary glomerulonephritis is the leading cause of chronic kidney disease and end-stage renal disease in China and many other countries. Recently, there has been much progress with regard to pathogenesis as well as treatment of primary glomerulonephritis. Clinical data from Chinese studies have significantly contributed to the making of international guidelines and histological classifications of the disease. This book focuses on the cutting-edge knowledge and provides up-to-date information on primary glomerulonephritis. Topics covered are IgA nephropathy, focal segmental glomerulosclerosis, membranous nephropathy, membranoproliferative glomerulonephritis, and crescentic glomerulonephritis.

Chapter

Primary Glomerulonephritis in Mainland China: An Overview

Abstract

Minimal Change Disease

Focal Segmental Glomerulosclerosis

IgA Nephropathy

Idiopathic Membranous Nephropathy

Membranoproliferative Glomerulonephritis

Acknowledgements

References

Advances in the Pathology of Glomerular Diseases

Abstract

Epithelial Cell Injury – Podocytopathies and Membranous Nephropathy

Pathology of Membranous Glomerulopathy

Endothelial Cell Injury – ANCA-Associated Renal Pathology

Complement System and Glomerular Pathology

Endothelial Cell Injury – Complement and HUS

Renal Pathology and the Prognosis of Glomerular Disease

References

Changing Spectrum of Biopsy-Proven Primary Glomerular Diseases over the Past 15 Years: A Single-Center Study in China

Abstract

Patients and Methods

Results

Discussion

Acknowledgements

References

Evaluation of Anemia and Serum iPTH, Calcium, and Phosphorus in Patients with Primary Glomerulonephritis

Abstract

Materials and Methods

Results

Discussion

Acknowledgments

References

IgA Nephropathy

Role of Podocyte Injury in IgA Nephropathy

Abstract

Pathogenesis

Acknowledgements

References

Genetic Studies of IgA Nephropathy: What Have We Learned from Genome-Wide Association Studies

Abstract

Pathogenesis

Genetics of IgAN: Before the GWAS Era

Genetics of IgAN: GWAS Era

6p21 (top SNPs: rs9275596, rs9275224, rs2856717) (Candidate Genes: HLA-DRB1, -DQA1, -DQB1 )

6p21 (top SNPs: rs1883414) (Candidate Genes: HLA-DPB2, -DPB1, -DPA1, and COL11A2 )

6p21 (top SNPs: rs9357155) (Candidate Genes: PSMB8, PSMB9, TAP1, TAP2 )

1q32 (top SNPs: rs6677604) (Candidate Genes: CFH and CFHR Gene Cluster)

22q12 (top SNPs: rs2412971) (Candidate Genes: HORMAD2, MTMR3, LIF, OSM, GATSL3, SF3A1 )

8p23 (top SNPs: rs2738048) (Candidate Genes: DEFA Gene Cluster)

17p13 (top SNPs: rs3803800) (Candidate Genes: TNFSF13, MPDU1, EIF4A1, CD68, TP53, SOX15 )

Risk Score and Geospatial Model

A New Pathogenesis Model

Conclusion

Acknowledgments

References

Immunopathological Predictors of Prognosis in IgA Nephropathy

Abstract

Immunopathological Predictors of Prognosis

Conclusion

Acknowledgments

Disclosure Statement

References

Treatment of Progressive IgA Nephropathy: An Update

Abstract

Proteinuria, Hypertension, Glomerular Filtration Rate, and Renal Pathological Lesions Are the Main Factors in Determining the Treatment Scheme for Progressive IgAN

Supportive Therapy

Glucocorticoid Therapy

Immunosuppressant Therapy

Conclusion

Acknowledgments

References

Focal Segmental Glomerulosclerosis/Minimal Change Disease

Different Targets for Treating FocalSegmental Glomerular Sclerosis

Abstract

References

Screening of ACTN4 and TRPC6 Mutations in a Chinese Cohort ofPatients with Adult-Onset Familial Focal Segmental Glomerulosclerosis

Abstract

Materials and Methods

Results

Discussion

Acknowledgements

References

Increased Risk of Treatment Failure and End-Stage Renal Disease in Familial Focal Segmental Glomerular Sclerosis

Abstract

Introduction

Patients and Methods

Results

Discussion

Conclusion

Acknowledgements

References

Treatment and Prognosis of Primary Focal Segmental Glomerulosclerosis

Abstract

Materials and Methods

Results

Discussion

Acknowledgements

References

New Insights into Treatment of Nephrotic Syndrome in Children

Abstract

Definitions Used for Nephrotic Syndrome

Pathology

Treatment of the Initial Episode of SSNS

Treatment for Relapse SSNS, SDNS, and SRNS

Evaluation and Monitoring

Conclusion

References

Membranous Nephropathy

Pathogenesis of Membranous Nephropathy: A New Paradigm in Evolution

Abstract

Primary Membranous Nephropathy Mediated by Anti-PLA2R1 Autoantibody

Recurrence of Primary Membranous Nephropathy in Renal Allografts

Non-PLA2R1 Antigen-Antibody Systems in Primary Membranous Nephropathy

Secondary Membranous Nephropathy: Antigen-Antibody Systems

Concluding Remarks

Disclosure Statement

References

Short-Term Complications of Membranous Nephropathy

Abstract

Hypertension

Dyslipidemia

Proteinuria

Edema Management

Hypercoagulability and Venous Thromboembolism

Risk of Infection

References

Tacrolimus Combined with Corticosteroids in Idiopathic Membranous Nephropathy: A Randomized, Prospective, Controlled Trial

Abstract

Materials and Methods

Results

Discussion

Acknowledgments

References

Membranoproliferative Glomerulonephritis

Membranoprolferative Glomerulonephritis – Mechanismsand Treatment

Abstract

Classification of MPGN

Mechanism of Glomerular Damage in MPGN

Alternative Pathway of Complement Activation

Evaluation of the Patient with MPGN

Treatment of MPGN in 2013

References

Re-Evaluation of the Classification System for Membranoproliferative Glomerulonephritis

Abstract

Materials and Methods

Results

Discussion

Conclusion

Acknowledgments

References

C3 Glomerulopathy

Abstract

Histology

Composition of the Deposits

Role of Complement Alternative Pathway in C3 Glomerulopathy

Clinical Features

Treatment

References

Hepatitis C Virus-Associated Glomerulonephritis

Abstract

Discovery of the HCV

HCV Virology and Replication

Epidemiology

Natural History of Acute and Chronic HCV Infection

Extrahepatic Manifestation

Pathogenesis of HCV-Associated of GN

Clinical Findings in HCV-Related Cryoglobulinemia

Cryoglobulinemic Glomerulonephritis

Laboratory and Pathologic Findings

Treatment

Acknowledgments

References

Crescentic Glomerulonephritis

Pathogenesis of Rapidly Progressive Glomerulonephritis: What Do We Learn?

Abstract

Anti-GBM Nephritis

ANCA-Associated Glomerulonephritis

Conclusion

Acknowledgements

References

ANCA-Associated Renal Vasculitis – An Update

Abstract

New Classification of AAV – Are Anti-PR3-Positive and Anti-MPO-Positive AAV Distinct Diseases?

New Classification of Renal Histology in AAV

News in the Pathogenesis

Long-Term Outcome of the Patients

Standard Treatment

Rituximab

Acknowledment

References

Management of Crescentic Glomerulonephritis: What Are the Recent Advances?

Abstract

Current Therapies for Crescentic Glomerulonephritis

Novel Therapeutic Strategies

Conclusion

Acknowledgements

References

Plasma Exchange in the Treatment of Rapidly Progressive Glomerulonephritis

Abstract

Modalities of Plasmapheresis

Application of Plasmapheresis in RPGN

Potential Complications

Conclusions

Acknowledgments

References

Author Index

Subject Index

Cover

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