Description
In this volume, some of the leading authorities present their exploration of applications of stem cell therapy to the treatment of major causes of blindness, including degenerative diseases and glaucoma. The diagnostic approach to patients, general concepts of cell-based therapy, immunological considerations, approaches to cell delivery (including engineered scaffolds), combined cell and gene therapy, nanomedicine applications to cell therapy and regulatory issues pertaining to manufacture and production are all considered in detail. The book serves as an excellent introduction to a field that is now entering early-stage clinical trials and promises to operate at the leading edge of regenerative medicine. Retina specialists, general ophthalmologists as well as researchers will find here a wealth of information on the translational aspects of cell-based therapies. Further, business executives and students interested in understanding the potential applications of stem cell therapy to retinal degenerative disease and glaucoma will also find this book informative reading.
Chapter
Age-Related Macular Degeneration: Clinical Findings, Histopathology and Imaging Techniques
Age-Related Macular Degeneration: Background
Imaging Early Age-Related Macular Degeneration
Imaging Indocyanine Green
Optical Coherence Tomography
Near-Infrared Fundus Reflectance
Imaging Geographic Atrophy
General Pathophysiology in Retinal Degeneration
Brief Overview of the Eye
Retina and Retinal Pigment Epithelium
Phototransduction Cascade
Mechanisms of Degeneration
Juvenile-Onset Macular Degeneration and Allied Disorders
Definitions, Basic Concepts, Classifications
Diagnosis and Complementary Examinations
Assessment of Visual Function
Assessment of Retinal Structure: Imaging
Stem Cells for Retinal Repair
Stem Cells for Retinal Repair
Retinal Pigment Epithelial Stem Cells
Neural Retina Stem and Progenitor Cells
Neural Stem and Progenitor Cells
Differentiation of Pluripotent Stem Cells into Retinal Pigmented Epithelium
The Case for Cellular Therapies
Derivation of Retinal Pigmented Epithelium from Pluripotent Stem Cells
The Continuous Adherent Culture Method
The Embryoid Body Approach
Other Sources of Retinal Pigmented Epithelium
Induced Pluripotent or Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium?
Transplantation Strategies
Clinical Trial Progression
Neural Retinal Regeneration with Pluripotent Stem Cells
Retinal Histogenesis and Anatomy
Transplantation Strategies
Protocols for Deriving Neural Retina from Pluripotent Stem Cells
Future Perspectives: Transplantation of Stem Cell-Derived Neural Retina in Humans
Small Molecule Induced Pluripotent Stem Cell Reprogramming and Retinal Induction
Immunological Considerations of Stem Cell Therapy in Retinal Disease
Stem Cells, Retinal Ganglion Cells and Glaucoma
Stem Cells: Immunology and Immunomodulation
Immunogenicity of Stem Cells
Overcoming the Immune Response to Stem Cells
Immunomodulatory Properties of Stem Cells
Biochemical Restoration of Aged Human Bruch’s Membrane: Experimental Studies to Improve Retinal Pigment Epithelium Transplant Survival and Differentiation
Biochemical Restoration of Aged Human Bruch’s Membrane
Approaches to Cell Delivery: Substrates and Scaffolds for Cell Therapy
Cells: Photoreceptor Precursors, Retinal Progenitor Cells, Retinal Pigment Epithelium
Transplants: Retinal Sheet Transplant and Bolus Injection
Substrate Materials, Fabrication Techniques and Specific Properties
Substrates and Scaffolds for Retinal Cell Delivery
Microdevice-Based Cell Therapy for Age-Related Macular Degeneration
Permeability of Submicron Parylene-C Membranes
Mesh-Supported Submicron Parylene-C Membranes
Perfusion Cell Viability Tests
In vitro Retinal Pigment Epithelial Cell Culture and Evaluation
Cell Therapy: Grafting Wild-Type, Allogeneic Photoreceptors and Retinal Pigment Epithelium to Rescue Genetic Defects
Gene Correction of Autologous Induced Pluripotent Stem Cells for Gene and Cell Therapy
Sequential Gene and Cell Therapy
Encapsulated Cell Technology for Protein Therapy of Genetic Disease
Cellular Manufacturing for Clinical Applications
Regulatory Issues in Cell-Based Therapy for Clinical Purposes
Donor Screening and Testing
Quality Management System
Cell-Based Therapy for Retinal Degenerative Disease
( Developments in Ophthalmology )
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
