Description
The term ‘carcinoid’ entered medical literature over 100 years ago to describe a peculiar intestinal epithelial neoplasm. Since then, a large body of literature has expanded the concept of carcinoid, later replaced by the term ‘NeuroEndocrine Tumor’ (NET), defining a wide spectrum of peculiar tumors, potentially affecting all organs and tissues, originating from neuroendocrine cells, sharing, but, at the same time, keeping, pathognomonic pathological, radiological and clinical features. This book provides an authoritative overview of the epidemiological, clinical, genetic, molecular and pathological characteristics of NETs and highlights the most relevant controversial issues in the classification, diagnosis and therapy. Furthermore the new frontiers in the field of medical therapies are presented, through a multidisciplinary and translational approach. Considering the fact that NETs have been recently demonstrated less rare as considered so far, 'Neuroendocrine Tumors: A Multidisciplinary Approach' is a must read for endocrinologists, gastroenterologists, endocrine surgeons, as well as pathologists, nuclear medicine physicians and radiologists focused on NET.
Chapter
Sources of Information on Neuroendocrine Tumor Epidemiology
Biochemical Testing in Patients with Neuroendocrine Tumors
Tumor Markers in Neuroendocrine Tumors
Clinical Syndromes Related to Gastrointestinal Neuroendocrine Neoplasms
Clinical Syndromes Secondary to Gastrointestinal Neuroendocrine Neoplasms
Clinical Syndromes of Gastrointestinal Neuroendocrine Neoplasms According to the Tissue of Origin
Treatment of the Carcinoid Syndrome and Related Syndromes
Clinical Syndromes of Gastrointestinal Neuroendocrine Neoplasms According to the Tissue of Origin
Treatment of the Carcinoid Syndrome and Related Syndromes
Paraneoplastic Syndromes Secondary to Neuroendocrine Tumors
Treatment of Clinical Syndromes Related to Pancreatic Neuroendocrine Neoplasms
Radiological Imaging: Computed Tomography, Magnetic Resonance Imaging and Ultrasonography
Image Surveillance and Monitoring of Neuroendocrine Tumor Therapy
Nuclear Medicine Imaging of Neuroendocrine Tumors
Imaging of Neuroendocrine Tumors
Somatostatin Receptor-Based Imaging
Somatostatin Receptor PET/CT
Imaging Response after Therapy
Endoscopy and Endoscopic Ultrasound in Assessing and Managing Neuroendocrine Neoplasms
Gastrointestinal Neuroendocrine Neoplasms
Pancreatic Neuroendocrine Neoplasms
EUS-Guided Fine-Needle Aspiration and Biopsy, and Newer Techniques
Pathology: Classification and Immunoprofile
Classification of Neuroendocrine Neoplasms in the Gastroenteropancreatic System
Classification in the Lung, Thymus and Genitourinary Tract
Important Organ-Specific Features
Genetics and Epigenetics of Pancreatic Neuroendocrine Tumors and Pulmonary Carcinoids
Inherited Neuroendocrine Tumor Predisposition Syndromes
Genetic and Epigenetic Studies in Sporadic Neuroendocrine Tumors
Therapeutic Consequences of Genetic and Epigenetic Studies in Neuroendocrine Tumors
Surgical Approaches for Primary Tumor with Clinical Endocrine Syndrome
Localized Nonfunctioning Pancreatic Neuroendocrine Tumors
Locally Advanced Pancreatic Neuroendocrine Tumors
Open or Laparoscopic Approach?
Gastrointestinal Surgery of Neuroendocrine Neoplasms
Esophageal Neuroendocrine Neoplasms
Gastric Neuroendocrine Neoplasms
Duodenal Neuroendocrine Neoplasms
Pancreatic Neuroendocrine Neoplasms
Small Intestinal Neuroendocrine Neoplasms
Appendiceal Neuroendocrine Neoplasms
Colonic Neuroendocrine Neoplasms
Rectal Neuroendocrine Neoplasms
Neuroendocrine Carcinomas
Mixed Adenocarcinomas and Neuroendocrine Carcinomas
Neuroendocrine Liver Metastases
Transplantation and Debulking Procedures for Neuroendocrine Tumors
A 25-Year Experience of Gastroenteropancreatic Neuroendocrine Tumors and Somatostatin (Congeners) Analogs: From Symptom Control to Antineoplastic Therapy
Carcinoid Tumors Subjects
Pancreatic Neuroendocrine Tumor Subjects
Somatostatin Congener Depot Formulations
Medical Therapy of Pulmonary Neuroendocrine Neoplasms: Targeted,Symptomatic and Chemotherapy
Control of Associated (Neuro) Endocrine Hypersecretions
Control of Tumor Growth in the Metastatic Setting or in Patients Not Candidates for Surgery
Peptide Receptor Radionuclide Therapy of Neuroendocrine Tumors
Peptide Receptor Radionuclide Therapy Results
Hormone and Receptor Candidates for Target and Biotherapy of Neuroendocrine Tumors
Hormone Receptors in Neuroendocrine Tumors
Mechanisms Influencing Treatment Response and Uptake of Radiolabeled Somatostatin Analogs
Role of Hormone Receptors in the Diagnosis of Neuroendocrine Tumors
Clinical Experience of Targeting Hormone Receptors in Neuroendocrine Tumors
The Role of Chemotherapy in Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors
Streptozocin Combinations
Dacarbazine and Temozolomide
Temozolomide Combinations
Oxaliplatin-Based Regimens
Predictors of Response to Chemotherapy
Choice of Chemotherapy in Intermediate- to High-Grade Tumors
Other Novel Therapies: Biomarkers, microRNAs and microRNA Inhibitors, DNA Methylation, Epigenetics, Immunotherapy and Virotherapy
microRNAs and microRNA Inhibitors
Epigenetics of Neuroendocrine Tumors – DNA Methylation and Histone Modifications
Recent Advancements in Cancer Immunotherapy
Immune Checkpoint Antibodies
Adoptive Transfer of Genetically Engineered T Cells
Other Forms of Immunotherapy
Oncolytic Viruses as Immunotherapy
Immune Scoring of Tumors to Predict Clinical Outcome
Neuroendocrine Tumors: A Multidisciplinary Approach
( Frontiers of Hormone Research )
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