Cover

Front Matter

Contents

Preface

Clinical Effect of Pre-Dilution Hemodiafiltration Based on the Permeation of the Hemodiafilter

Abstract

Introduction

Materials and Methods

Results and Discussion

Conclusions

References

The Past, Present and Future of the Dialyzer

Abstract

Introduction

Dialysis Membranes

Dialyzers

References

Importance of Abnormal Bone Metabolism in the Acceleration of Atherosclerosis in Hemodialysis Patients

Abstract

Introduction

Mechanisms of Vascular Calcification

Involvement of Increased Phosphate Release from Bone via Bone Resorption during the Development of Vascular Calcification in Hemodialysis Patients ( fig. 1 )

Involvement of Adynamic Bone Disease Induced by Increased Calcium Load in the Development of Vascular Calcification in Hemodialysis Patients ( fig. 1 )

Vascular Calcification as a Definite Risk Factor for Cardiovascular Mortality in Hemodialysis Patients

Conclusion

References

Dysregulated Iron Metabolism in Patients on Hemodialysis

Abstract

Introduction

Iron Sequestration in Cells from Dialysis Patients

Iron Sequestration in Endothelial Cells by TNF-α

Iron Sequestration by Hepcidin Under Iron-Overload Conditions

Endosomal Iron Sequestration by TNF-α

Misregulation of Mitochondrial Proteins

Conclusions

References

The Present Status of and Perspectives on Home Hemodialysis Therapy in Japan

Abstract

Introduction

Present Status of Home Dialysis Therapy Around the World

Clinical Advantages of Home Hemodialysis Therapy

Problems with Longer and More Frequent Dialysis Programs

Activities of the Japanese Society for Home Hemodialysis

Summary

References

Safety and Efficacy Evaluation of Lanthanum Carbonate for Hyperphosphatemia in End-Stage Renal Disease Patients

Abstract

Introduction

The Therapeutic Effect of Lanthanum Carbonate for Hyperphosphatemia

The Long-Term Effects and Safety Evaluation of Lanthanum Carbonate for Hyperphosphatemia in Hemodialysis Patients

Plasma Lanthanum Concentrations in Hemodialysis Patients with Lanthanum Carbonate Prescriptions

Bone Metabolism Markers in Hemodialysis Patients with Lanthanum Carbonate Prescriptions

Bone Histological Changes in Hemodialysis Patients with Lanthanum Carbonate Prescriptions

Our Opinions and Comments about Safety Evaluation of Lanthanum Carbonate

Conclusions

Funding

References

Klotho/FGF23 Axis in CKD

Abstract

Introduction

Klotho: Its Biology and Function

FGF23: Its Biology and Function

Klotho/FGF23 and the Parathyroid Gland

The Klotho/FGF23 Axis in Chronic Kidney Disease

Future Prospects

References

Cell Sheet-Based Tissue Engineering for Mesothelial Cell Injury

Abstract

Introduction

Anatomical Characterization of Mesothelial Cells

Functions of Mesothelial Cells

Mesothelial Cell Regeneration

Basic Cell Sheet Engineering Technology

Clinical Applications of Cell Sheets

Attempts to Apply Cell Sheet Technology to Peritoneal Regeneration

Mesothelial Cell Transplantation

Conclusion

Acknowledgments

References

Erythropoiesis-Stimulating Agent Hyporesponsiveness in End-Stage Renal Disease Patients

Abstract

Introduction

Definition and Diagnosis

Pathogenesis

Proposed Approach to ESRD Patients with ESA Hyporesponsiveness

Conclusion

References

Past and Present Perspectives on Encapsulating Peritoneal Sclerosis

Abstract

Overview of Encapsulating Peritoneal Sclerosis

Epidemiology of Encapsulation Peritoneal Sclerosis in Peritoneal Dialysis Patients

Pathogenesis of Encapsulating Peritoneal Sclerosis

Diagnosis

Prevention and Treatment

Treatment

Conclusions

References

DPP-4 Inhibitors in Diabetic Patients with Chronic Kidney Disease and End-Stage Kidney Disease on Dialysis in Clinical Practice

Abstract

Introduction

Antihyperglycemic Strategies for Diabetic Patients with Chronic Kidney Disease

Antihyperglycemic Agents in Patients with Chronic Kidney Disease or End-Stage Kidney Disease on Dialysis

Dosing Adjustment of DPP-4 Inhibitors in Patients with Chronic Kidney Disease

Efficacy of DPP-4 Inhibitors in Diabetic Patients with Chronic Kidney Disease

Effects of DPP-4 Inhibitors on the Kidney

Tolerability and Safety Issues with DPP-4 Inhibitors in Patients with Chronic Kidney Disease

Glycemic Control Indices and Their Target Levels in End-Stage Kidney Disease Patients on Dialysis

Clinical Characteristics of Glycemic Control in Dialysis Patients

Effects of DPP-4 Inhibitors in End-Stage Kidney Disease Patients on Dialysis

Conclusions

Acknowledgments

References

Present Status and Future of Peritoneal Dialysis in Japan

Abstract

Introduction

Peritoneal Dialysis Trends in Japan (from the Nationwide Statistical Survey)

Trends in Peritoneal Dialysis+Hemodialysis Combination Therapy and Icodextrin Use in Japan (fig. 1)

Trends in Continuous Ambulatory Peritoneal Dialysis and Automated Peritoneal Dialysis in Japan

What Factors Prevent the Number of Peritoneal Dialysis Patients in Japan from Increasing?

What is the Role of Peritoneal Dialysis for End-Stage Renal Disease Patients in Japan?

References

Cost-Effectiveness of Hemodialysis in Japan

Abstract

Introduction

Concept of Cost-Effectiveness

Comparative Analysis of Hemodialysis and Online Hemodiafiltration

Comparative Analysis of Diabetic Nephropathy and Glomerulonephritis

Discussion

Conclusion

Acknowledgment

References

Vascular Access for Long-Term Hemodialysis/Hemodiafiltration Patients in Japan

Abstract

Introduction

Patients and Methods

Results

Discussion

References

New Aspects of Cerebrovascular Diseases in Dialysis Patients

Abstract

Brain-Kidney Linkage

Cerebrovascular Diseases in Dialysis Patients

Cognitive Impairment and Dementia

Recommendations for Future Studies

Conclusion

References

Current Topics of Purification and Constitutions of Dialysis Fluid

Abstract

Introduction

Purification of Dialysis Fluid

Water Quality Standards for Dialysates

Effects of Dialysis Fluid Purification

Actual Status of Dialysis Fluid Purification

Composition of Dialysis Fluid

References

Vascular Calcification in End-Stage Renal Disease Patients

Abstract

Introduction

Pathophysiology of Vascular Calcification

Metabolism of Calcium and Phosphate and Vascular Calcification

Fibroblast Growth Factor-23 and Vascular Calcification

Inhibitors of Vascular Calcification

Assessment of Vascular Calcification

Treatment of Vascular Calcification

Conclusion

References

Author Index

Subject Index

Cover