Cover

Front Matter

Contents

Foreword

Preface

Mistletoe through Cultural and Medical History: The All-Healing Plant Proves to Be a Cancer-Specific Remedy

Abstract

Archaeological Findings and Early Scientific Observations

Mythological Aspects

Mistletoe in the History of Medicine

Oak Mistletoe

Introduction of Mistletoe into Cancer Therapy

Methodological Roots

Conclusion

References

Chemical Constituents of Viscum album L.: Implications for the Pharmaceutical Preparation of Mistletoe

Abstract

Introduction

Chemical Diversity and Features of Viscum album

Conclusions and Pharmaceutical Implications

References

The Anti-Cancer Activity of Mistletoe Preparations, as Related to Their Polyphenolic Profiles

Abstract

Introduction

The Polyphenolic Constituents of Mistletoe Preparations

Metabolism, Energy Homeostasis and Cancer

Polyphenols Under Investigation in Oncology

Some Distinctive Properties of Mistletoe Preparations and Polyphenols in Relation to Their Anti-Cancer Modes of Action

Pro- or Anti-Oxidative Properties of Mistletoe Preparations and Polyphenols in Respect to Target Cells

Oestrogenic and Anti-Oestrogenic Activities and Inhibition of Aromatase

Glucose Metabolism

Lipid Metabolism of Cancer Cells: Inhibition of Fatty Acid Synthase

Action on Enzymes of Detoxification Phases I and II

Risk Factors of Cancer: Obesity and Underweight

The Different Modes of Action of the Various Polyphenols and the Assumed Corresponding Actions of Mistletoe Preparations

Dosages and Additive/Synergistic Modes of Action of Mistletoe Constituents

Discussion

References

From Berlin and Witten to Southampton and Hamburg: 25 Years of Mistletoe Research Cooperation

Abstract

Mistletoe Research and International Meetings

The Lectin Story

Lectins and Immunocompetent Cells

Lectins and Malignant Tumors

Lectins and Binding Partners

Summary

References

Mistletoe Compounds as Anti-Cancer Drugs: Effects and Mechanisms in the Treatment of Glioblastoma

Abstract

Glioblastoma Multiforme

Mistletoe Compounds: General Mode of Action

Mistletoe Treatment Alters Gene Expression

Mistletoe Extracts as Immunomodulatory Drugs in the Treatment of Glioblastoma Multiforme

Mistletoe and Cell Motility

Therapeutic Effects of Mistletoe in Experimental Rodent Glioblastoma Multiforme Models

Clinical Trials Using Mistletoe for the Treatment of Glioma Patients

Conclusion

References

Cancer Surgery and Supportive Mistletoe Therapy: From Scepticism to Randomised Clinical Trials

Abstract

Introduction

Conventional Oncology and Mistletoe

Quality of Life and Mistletoe

Cochrane Reviews and Mistletoe

Pancreatic Cancer and Mistletoe: From Single Cases to Randomised Clinical Trials

Conclusion

References

Dissecting the Anti-Inflammatory Effects of Viscum album : Inhibition of Cytokine-Induced Expression of Cyclo-Oxygenase-2 and Secretion of Prostaglandin E2

Abstract

Viscum album Preparations

Inflammation and Cyclo-Oxygenase-2

Role of Viscum album in Inhibition of Cyclo-Oxygenase-2

Concluding Remarks

Acknowledgments

References

Dancing with the Devil: Cancer-Related Fatigue, from Inflammation to Treatment Options

Abstract

Introduction

Symptoms of Cancer-Related Fatigue

Mechanisms of Cancer-Related Fatigue

Nonpharmacological Treatment of Cancer-Related Fatigue

Diet and Cancer-Related Fatigue

Pharmacological Treatment of Cancer-Related Fatigue

Use of Herbal Medicine to Improve Cancer-Related Fatigue

Supportive Care for and Treatment of Cancer-Related Fatigue with Mistletoe Preparations

Conclusion

Acknowledgment

References

Author Index

Subject Index

Cover