Cover

Front Matter

Contents

Foreword

Preface and Introduction

References

Overview

Early Detection of Psychosis – State of the Art and Future Perspectives

Abstract

Early Detection of Risk

Psychosis High-Risk State

Predictive Accuracy of Early High-Risk Symptoms

Predictive Accuracy of Late High-Risk Symptoms

Improvement of Predictive Accuracy by Combining Criteria

Improving Predictive Accuracy by Biomarkers

References

Early Intervention in Emerging Psychosis: State of the Art and Future Perspectives

Abstract

Defining the Sub-Threshold Stage of Psychotic Illness and Its Consequences

The Psychosis Prodrome or a Pluripotential Risk Syndrome?

Interventions in the Sub-Threshold Stage

Novel Service Approaches to Maximise Recovery

Conclusion

References

Early Detection of Psychosis: Clinical Assessments

First Signs of Emerging Psychosis

Abstract

The Concept of Basic Symptoms

General Characteristics of Basic Symptoms

Basic Symptoms in the Early Detection of First-Episode Psychosis

Psychosis-Predictive Utility of Basic Symptom Criteria

Combining Basic Symptoms and Ultra-High-Risk Criteria

Basic Symptoms in Children and Adolescents

Conclusion

References

Psychosis High-Risk States in Adolescents

Abstract

Methods and Study Sample

Symptom Groups and Diagnostic Spectra

Conclusions

Acknowledgements

References

The Psychosis High-Risk State

Abstract

Clinical Relevance and Impact of Delayed Treatment

Detectable Preclinical Phase

The Screening Procedures

Positive Predictive Value

Epidemiology of Ultra-High-Risk Symptoms

Focused Interventions

Comparison with Other Preventative Approaches in Somatic Medicine

Risk Syndrome or Mental Disorder

Conclusions and Future Directions

References

Early Detection of Psychosis – Helpful or Stigmatizing Experience for Those Concerned?

Abstract

General Concepts of Stigma and Labeling

Stigma in Those Affected by Psychosis/Schizophrenia

Stigma in Individuals with an At-Risk Mental State for Psychosis

Helpful Aspects of Support Offered in Early Detection Services

Possible Interventions Regarding Stigma in Those Affected by an ARMS

Conclusions

References

Early Detection of Psychosis: Neuroimaging

Structural and Functional MRI in the Prediction of Psychosis

Abstract

The Rationale of Finding Predictive Markers Using Neuroimaging

Structural MRI of the High-Risk State

Functional MRI in People at High Risk

Limitations and Future Directions

Conclusions

References

Pattern Recognition Methods in the Prediction of Psychosis

Abstract

Multivariate Pattern Analysis Methods

Pattern Recognition Applications in the Early Recognition of Psychosis

Challenges Ahead

References

Connectivity Abnormalities in Emerging Psychosis

Abstract

Structural Connectivity Abnormalities

Functional Connectivity Abnormalities

Potential Developments for Future Research

Conclusions

References

Early Detection of Psychosis: Neurocognitive and Neurophysiological Assessments

Neurocognition and Motor Functioning in the Prediction of Psychosis

Abstract

Cognitive and Motor Dysfunction in the Prediction of Psychosis

Methodological Problems

Conclusions

References

Electroencephalographic Predictors of Psychosis

Abstract

Predicting Psychosis by Electroencephalography

Future Perspective

References

Early Intervention in Emerging Psychosis

Psychological Methods of Early Intervention in Emerging Psychosis

Abstract

Rational for Interventions in Emerging Psychosis

Characteristics of People Meeting Clinical High-Risk Criteria

Psychological Methods of Early Intervention in Emerging Psychosis

Aims of Psychological Early Intervention in Emerging Psychosis

Psychoeducation in Emerging Psychosis

Psychotherapy in Emerging Psychosis

Conclusions

Clinical Implications

Can Early Detection and Intervention of Psychosis Be Implemented in Routine Care?

Acknowledgement

Disclosure Statement

References

Nonpharmalogical Substances for Early Intervention

Abstract

Polyunsaturated Fatty Acids

N-Methyl-D-Aspartate Receptor Agonists

Redox Dysregulation

Conclusions

References

Pharmacological Intervention in First-Episode Psychosis

Abstract

Mechanism of Action of Antipsychotic Medication

Treatment Guidelines and Dosing

Effectiveness

Side Effects and Management

Compliance/Adherence

How Long Should Antipsychotic Medication Be Continued?

Controversies with Antipsychotic Medication

Conclusion

References

Conclusions and Future Perspectives

Early Detection and Intervention in Psychosis

Abstract

Early Detection

Early Intervention

Problems to Be Solved

References

Author Index

Cover