Cover

Front Matter

Contents

List of Contributors

Preface

Epidemiology

The Burden of Diabetes: Emerging Data

Abstract

References

The Eye as a Window to the Microvascular Complications of Diabetes

Abstract

Diabetic Retinopathy

Diabetic Neuropathy

Diabetic Nephropathy

Conclusion

References

Pathogenesis and Imaging

Emerging Insights into Pathogenesis

Abstract

Introduction

Neuronal Cell Degeneration

Retinal Glial Cell Activation

Retinal Microglial Cell Activation

Conclusion

Acknowledgments

References

Emerging Issues for Optical Coherence Tomography

Abstract

References

Optical Coherence Tomography Angiography in Diabetic Maculopathy

Abstract

Introduction

Definition and Principles of OCT-A

Imaging Techniques

Technical Aspects

Macular OCT-A: Superficial and Deep Capillary Plexuses

Choriocapillaris and Choroidal Assessment

Diabetic ME

Focal Hyperintense Clumps

DME: Different Degrees of Macular Involvement

Diabetic Macular Ischemia

Follow-Up after Treatment

Quantitative Image Analysis

Conclusions

References

Emerging Issues for Ultra-Wide Field Angiography

Abstract

Optos Camera

Ultra-Wide Field in DR

Conclusions

References

Emerging Simplified Retinal Imaging

Abstract

MII Ret Cam

Advantages

Limitations

Information

Paxos Scope

Advantages

Limitations

Information

Volk InView

Advantages

Limitations

Information

D-Eye

Advantages

Limitations

Information

Epicam

Advantages

Limitations

Information

Disclaimer

References

Treatment

Intravitreal Ranibizumab in Diabetic Macular Edema: Long-Term Outcomes

Abstract

Financial Disclosures

References

Intravitreal Aflibercept in Diabetic Macular Edema: Long-Term Outcomes

Abstract

Introduction

The DAVINCI Study

VISTA and VIVID

DRCR.net Protocol T

Conclusion

References

Intravitreal Steroids in Diabetic Macular Edema

Abstract

Triamcinolone Acetonide

Dexamethasone

Fluocinolone Acetonide

Conclusions

References

Practical Lessons from Protocol I for the Management of Diabetic Macular Edema

Abstract

Protocol I Findings

References

Practical Lessons from Protocol T for the Management of Diabetic Macular Edema

Abstract

Introduction

Description of Study and Protocol

Baseline Characteristics

Year-1 Results

Year-2 Results

Analysis of Cost Effectiveness and Burden of Care

DME Treatment in Clinical Practice

Safety

Take Away Points from Protocol T for thePracticing Clinician

References

Is Laser Still Important in Diabetic Macular Edema as Primary or Deferral Therapy?

Abstract

Introduction

Laser for Peripheral Retina

Laser for DME

Current Indications for Macular Laser in DME

Combined Therapy of Anti-VEGF and Macular Laser Photocoagulation

Peripheral Retinal Photocoagulation and DME

Conclusions

References

Anti-Vascular Endothelial Growth Factor Injections: The New Standard of Care in Proliferative Diabetic Retinopathy?

Abstract

Introduction

Protocol S

Discussion

Future Directions

References

Surgical Management and Techniques

Abstract

Introduction

Pre-Operative Assessment

Techniques

Vitreous Hemorrhage

Florid DR

Tractional RD

Diabetic Macular Edema

Neovascular Glaucoma

Cataract Surgery

Final Considerations

References

Enzymatic Vitreolysis for Vitreomacular Traction in Diabetic Retinopathy

Abstract

References

Diabetic Macular Edema: Emerging Strategies and Treatment Algorithms

Abstract

Introduction

Evolution of DME Treatments

Existing DME Treatment Algorithms

Emerging DME Treatment Strategies

Conclusion

References

Application of Clinical Trial Results to Clinical Practice

Abstract

Introduction

Two Problems Relevant to the Application of Clinical Trial Results to Clinical Practice

Frequentist Statistics: p versus Alpha [9, 10]

Reproducibility of Study Results

Five Questions to Assess Likelihood of Reproducing a Trial Result in Clinical Practice

Clinical Importance of Trial Results

Conclusions

References

Subject Index

Cover