Description
Recently developed diagnostic and therapeutic technologies such as OCT-angiography and small gauge vitrectomy have influenced the modern treatment of diabetic retinopathy. This volume provides a summary of the state-of-the-art evidence-based approach to managing complications that may occur with diabetic retinopathy. It offers the latest information on pathogenesis and diagnosis, and highly experienced clinicians review the results of relevant randomized clinical trials that serve as the basis of current therapy. The book provides not only a summary of data from randomized trials but also an analysis and interpretation by internationally renowned experts. Ophthalmology residents, fellows, and practicing clinicians will find this book to be a useful reference when seeking evidence-based treatment strategies for various complications of diabetic retinopathy. It is also for researchers identifying new avenues of drug developments and for insurance professionals and health care policy administrators who are establishing evidence-based therapy guidelines for therapeutic intervention.
Chapter
The Burden of Diabetes: Emerging Data
The Eye as a Window to the Microvascular Complications of Diabetes
Emerging Insights into Pathogenesis
Neuronal Cell Degeneration
Retinal Glial Cell Activation
Retinal Microglial Cell Activation
Emerging Issues for Optical Coherence Tomography
Optical Coherence Tomography Angiography in Diabetic Maculopathy
Definition and Principles of OCT-A
Macular OCT-A: Superficial and Deep Capillary Plexuses
Choriocapillaris and Choroidal Assessment
Focal Hyperintense Clumps
DME: Different Degrees of Macular Involvement
Diabetic Macular Ischemia
Follow-Up after Treatment
Quantitative Image Analysis
Emerging Issues for Ultra-Wide Field Angiography
Emerging Simplified Retinal Imaging
Intravitreal Ranibizumab in Diabetic Macular Edema: Long-Term Outcomes
Intravitreal Aflibercept in Diabetic Macular Edema: Long-Term Outcomes
Intravitreal Steroids in Diabetic Macular Edema
Practical Lessons from Protocol I for the Management of Diabetic Macular Edema
Practical Lessons from Protocol T for the Management of Diabetic Macular Edema
Description of Study and Protocol
Analysis of Cost Effectiveness and Burden of Care
DME Treatment in Clinical Practice
Take Away Points from Protocol T for thePracticing Clinician
Is Laser Still Important in Diabetic Macular Edema as Primary or Deferral Therapy?
Laser for Peripheral Retina
Current Indications for Macular Laser in DME
Combined Therapy of Anti-VEGF and Macular Laser Photocoagulation
Peripheral Retinal Photocoagulation and DME
Anti-Vascular Endothelial Growth Factor Injections: The New Standard of Care in Proliferative Diabetic Retinopathy?
Surgical Management and Techniques
Enzymatic Vitreolysis for Vitreomacular Traction in Diabetic Retinopathy
Diabetic Macular Edema: Emerging Strategies and Treatment Algorithms
Evolution of DME Treatments
Existing DME Treatment Algorithms
Emerging DME Treatment Strategies
Application of Clinical Trial Results to Clinical Practice
Two Problems Relevant to the Application of Clinical Trial Results to Clinical Practice
Frequentist Statistics: p versus Alpha [9, 10]
Reproducibility of Study Results
Five Questions to Assess Likelihood of Reproducing a Trial Result in Clinical Practice
Clinical Importance of Trial Results