Cover

Contents

Preface

History and Evolution of Hemodiafiltration

Dawn of Hemodiafiltration

Abstract

First 60 Years (1914 – Early 1970s)

Middle Molecule Hypothesis and HF

Development of HDF

The Current Status of HDF in Japan

References

Hemodiafiltration – State of the Art

Abstract

Online Hemodiafiltration

References

Hemodiafiltration: Evolution of a Technique towards Better Dialysis Care

Abstract

Hemodiafiltration: From Origin to Today

Techniques of Hemodiafiltration

Mechanism of Hemodiafiltration

Clinical Outcomes Achieved by HDF

Conclusion

References

Clinical Benefits of Hemodiafiltration

Optimal Therapeutic Conditions for Online Hemodiafiltration

Abstract

Technical Prerequisite and Basic Hygienic Rules for ol-HDF

Prerequisite and Technical Options of ol-HDF

ol-HDF Prescription in Practice

Handling and Microbial Monitoring of ol-HDF

Conclusions

References

Effect of Hemodiafiltration on Mortality, Inflammation and Quality of Life

Abstract

Mortality

Inflammation

Health-Related Quality of Life

Treatment Optimization Parameters

Conclusion

References

How to Prescribe Hemodialysis or Hemodiafiltration in Order to Ameliorate Dialysis-Related Symptoms and Complications

Abstract

Classical Parameters for Prescribing a Dialysis Modality

New Concept for Prescribing a Dialysis Modality

Results of the Dialysis Prescription Based on the POD System

Rationale of the New Concept for a Dialysis Prescription

Practice Pattern for Prescribing Online HDF from a Case Study

Conclusion

References

Optimizing Home Dialysis: Role of Hemodiafiltration

Abstract

Benefits of HDF over Low-Flux and High-Flux Hemodialysis

Individualizing Choice of Renal Replacement Therapy

Providing HDF at Home: Technical Considerations

Dialysis Adequacy for Home HDF

Equipment Portability

Conclusion

Acknowledgement

References

Management of Dialysis Fluid and Dialysis System

Quality Management of Dialysis Fluid for Online Convective Therapies

Abstract

Online Preparation of Substitution Solution for Convective Therapies

Components of a Quality Management System

References

Biocompatibility of Dialysis Fluid for Online HDF

Abstract

Purification of Online Preparation

Composition of Dialysis and Substitution Fluids

Methods

Results

Discussion

Conclusion

References

Characteristics of Central Dialysis Fluid Delivery System and Single Patient Dialysis Machine for HDF

Abstract

Central Dialysis Fluid Delivery System in Japan

SPDM in Japan

Substitution Fluid for Online HDF with CDDS and SPDM

Maintenance of Purification of Dialysis Fluid

HD and/or Online HDF Using SPDM by Comprehensive Management

Conclusion

References

Fully Automated Dialysis System for Online Hemodiafiltration Built into the Central Dialysis Fluid Delivery System

Abstract

Outline of the Central Dialysis Delivery System

FADS with Online HDF

Fully Automated Dialysis System

Dialysis Fluid Quality Control Standards

Fluid Quality Control Method

Discussion

References

Uremic Toxins

New Uremic Toxins – Which Solutes Should Be Removed?

Abstract

Toxicity of Specific Uremic Retention Solutes

Removal of Protein-Bound Uremic Solutes and Middle Molecules

Interventional Outcome Studies Based on Removal

Conclusions

References

Beta-2-Microglobulin as a Uremic Toxin: the Japanese Experience

Abstract

β2-Microglobulin and Dialysis-Related Amyloidosis

Therapeutic Approaches

Conclusion

References

Markers and Possible Uremic Toxins: Japanese Experiences

Abstract

Oxidative Stress and AGEs in ESRD

Vitamin E-Coated Dialysis Membrane

Clinical Effects of Vitamin E-Coated Dialyzer

Conclusion

References

Dialysis Membranes for Hemodiafiltration

Biocompatibility of the Dialysis Membrane

Abstract

Complement Activation

Contact Pathway Activation

Platelet Activation

Monocyte Activation

Neutrophil Activation

Conclusion

References

Choice of Dialyzers for HDF

Abstract

Materials and Method

Results and Discussion

Conclusions

References

Estimation of Internal Filtration Flow Rate in High-Flux Dialyzers by Doppler Ultrasonography

Abstract

Materials and Methods

Results

Discussions

Conclusions

References

Clinical Aspects of Hemodiafiltration

Management of Anemia by Convective Treatments

Abstract

Pathogenesis of Anemia in Chronic Kidney Disease

Anemia and Dialysis Dose

Convective Treatments

Vitamin E-Coated Membranes

Online Treatments

Conclusions

References

Clinical Evaluation Indices for Hemodialysis/Hemodiafiltration in Japan

Abstract

Historical Review of Chronic HD Therapy in Japan

Influence of the Low Prevalence of Renal Transplantation on Chronic HD Therapy in Japan

Impacts of High-Flux Membrane Dialyzers on Clinical Indices of HD Patients

Impacts of HDF on the Clinical Indices of HD Patients

References

Effect of Large-Size Dialysis Membrane and Hemofiltration/Hemodiafiltration Methods on Long-Term Dialysis Patients

Abstract

Development of Protein-Permeable Dialysis Membrane

Removal of Uremic Substances and Loss of Albumin in Low MW Protein Region

Clinical Efficiency

Conclusion

References

Who Needs Acetate-Free Biofiltration?

Abstract

Background

Concept of Acetate-Free Biofiltration

Indication for AFB

AFHD vs. AFB

Conclusion

References

Improvement of Autonomic Nervous Regulation by Blood Purification Therapy Using Acetate-Free Dialysis Fluid – Clinical Evaluation by Laser Doppler Flowmetry

Abstract

Evaluation of Autonomic Function by NICOMM

Stability Index of Tissue Blood Flow in the Head

Evaluation of Blood Purification Modalities with the Head SI

Conclusions

References

Preservation of Residual Renal Function with HDF

Abstract

Background

Study 1

Study 2

Study 3

Discussion

Acknowledgments

References

Author Index

Subject Index