Current Concepts in Uveal Melanoma ( Developments in Ophthalmology )

Publication series : Developments in Ophthalmology

Author: Desjardins L.; Kivelä T.; Damato B.E.  

Publisher: S. Karger AG‎

Publication year: 2011

E-ISBN: 9783805597913

P-ISBN(Paperback): 9783805597906

Subject: Q2 Cytobiology;R36 Pathology;R392 medical immunology;R73 Oncology;R77 Ophthalmology;R81 radiology

Keyword: 细胞生物学,放射医学,病理学,眼科学,肿瘤学,医学免疫学

Language: ENG

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Description

Uveal melanoma is an aggressive form of cancer that can involve the iris, the ciliary body, and/or the choroid, which is the main location of this tumor. Patients often wish to be informed about treatment choices and the results of different approaches. Important current clinical questions are whether a biopsy should be taken of choroidal melanomas, what should be done with this biopsy, and whether high-risk patients should be screened regularly.This volume describes the clinical characteristics of uveal melanoma along with the different current techniques available for treatment, such as radioactive plaque treatment, proton beam therapy, and local tumor resection. Furthermore, techniques for taking biopsies and characterizing biopsy material are demonstrated. Future therapies such as anti-VEGF treatment and options for the treatment of metastases are also discussed. Residents with an interest in ocular oncology, ophthalmologists or physicians dealing with uveal melanoma, as well as patients wishing to know more about this malignancy will find a topical update on uveal melanoma in this publication.

Chapter

Diagnosing Large to Medium- Sized Uveal Melanomas

Diagnosing Small Uveal Melanomas

References

Treatment Selection for Uveal Melanoma

Abstract

Clinical Scenarios

Method of Treatment Selection

Summary and Conclusions

References

Ruthenium-106 Brachytherapy

Abstract

The Ru-106 Applicator

The Use of Ru-106 Applicators for Uveal Melanoma

Results of Ru-106 Brachytherapy

Ru-106 Brachytherapy for Iris Melanoma

Combined Use of Ru-106 Brachytherapy with Other Treatment Modalities

Conclusions

References

Treatment of Uveal Melanoma by Accelerated Proton Beam

Abstract

Technique of Proton Beam Therapy for Uveal Melanoma

Indications

Evolution of the Tumor following Proton Beam Irradiation

Follow-Up of Patients

Results of Proton Beam Therapy

Additional Treatments

Conclusion

Acknowledgement

References

Stereotactic Photon Beam Irradiation of Uveal Melanoma

Abstract

Gamma Knife

Cyberknife

Linear Accelerator

Discussion

Acknowledgment

References

Local Resection of Uveal Melanoma

Abstract

Iridectomy

Iridocyclectomy

Choroidectomy

Endoresection

Discussion

Conclusions

References

Biopsies in Uveal Melanoma

Abstract

Diagnostic Intraocular Tumor Biopsy: Indications

Intraocular Tumor Biopsy: Contraindications

Intraocular Tumor Biopsy: Techniques

Safety

Biopsy for Cytogenetic Analysis

Heterogeneity

Conclusion

References

Analysis of Intraocular Biopsies

Abstract

Sample Handling and Processing

Examination of Anterior Segment Samples

Examination of Choroidal Samples

Prognostication and Intraocular Biopsies

Examination of Vitreous Samples

Non-Diagnostic Intraocular Biopsy

Conclusions

Acknowledgements

References

Anti-Angiogenic Therapy in Uveal Melanoma

Abstract

Tumor Angiogenesis in Uveal Melanoma

The Role of Vascular Endothelial Growth Factor

Approved Anti-Angiogenic Treatment in Cancer

Anti-Angiogenic Therapy in Uveal Melanoma

Adverse Effects of Anti-Angiogenic Therapy

Conclusion

References

Immunotherapy of Uveal Melanoma

Abstract

Protective Antitumor Immune Responses Capitalize on Adaptive Immunity by Tumor- Specific T Cells

Uveal Melanoma-Induced Immune Suppression Is a Hurdle to Overcome

Adapting Immunotherapy of Cutaneous Melanoma for Treatment of Uveal Melanoma

Therapeutic and Prophylactic Immunotherapy for Uveal Melanoma

Acknowledgements

Disclosure Statement

References

Genetic Determinants of Uveal Melanoma

Abstract

Predisposition to Uveal Melanoma

Genomic Abnormalities in Uveal Melanoma

Genome-Wide Expression Profiling

Genetic Pathways in Uveal Melanoma

MicroRNAs

Biochemical Pathways Correlated with Metastasis Development

Conclusion

Acknowledgments

References

Therapeutic Options in Metastatic Uveal Melanoma

Abstract

Locoregional Treatment

Systemic Treatment

Surgical Management of Liver Metastases

Conclusion

References

Subject Index

Cover

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