Cartilage and Bone Development and Its Disorders
( Endocrine Development )
Publication series ： Endocrine Development
Author： Camacho-Hübner C.; Nilsson O.; Sävendahl L.
Publisher： S. Karger AG
Publication year： 2011
E-ISBN: 9783805597937
P-ISBN(Paperback): 9783805597920
Subject： R394 medical genetics;R58 Endocrine disease and metabolic disease;R62 The orthopedic surgery (surgery) to repair;R68 (content in Kinesiology of Department of Orthopedics diseases, orthopedics);R72 Pediatrics
Keyword： 医学遗传学,骨科学（运动系疾病、矫形外科学）,儿科学,整形外科学（修复外科学）,内分泌腺疾病及代谢病
Language： ENG
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Description
In systemic childhood diseases, including cancer, gastrointestinal, pulmonary and cardiac disorders, childhood growth is severely impaired. In addition, almost 400 known genetic diseases inhibit the ability of the growth plate to form new bone, leaving affected children with growth failure and bony deformities which can severely impact their quality of life and may lead to morbidity and early mortality.This book provides a comprehensive review of bone and cartilage development, growth and disease. Focusing on novel treatment strategies, regulatory signals and molecular mechanisms are discussed in relation to the diseases affecting them. Furthermore, novel methodologies in bone and cartilage research based on recent advances in skeletal stem cell biology, cartilage tissue engineering and allele-specific gene silencing is covered.Providing insight into the basic mechanisms of bone growth, structure and metabolism, research methodology, as well as discussing the clinical management of related diseases, this book is of particular value to physicians with a special interest in bone and cartilage biology; in particular endocrinologists and pediatric endocrinologists that see patients with growth disorders, osteoporosis, osteogenesis imperfecta, and skeletal dysplasias.
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