Prophylaxis and Early Detection of HPV-Related Neoplasia ( Monographs in Virology )

Publication series : Monographs in Virology

Author: Pfister H.  

Publisher: S. Karger AG‎

Publication year: 2012

E-ISBN: 9783805599658

P-ISBN(Paperback): 9783805599641

Subject: D812 the friendly communication and mutual cooperation among the peoples of the world

Keyword: 传染病,流行病学与防疫,基础医学,预防医学、卫生学,耳鼻咽喉科学,肿瘤学,妇产科学

Language: ENG

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Description

Human papillomaviruses (HPV) are a heterogeneous and still growing virus family. Topical research results on the replication cycle and carcinogenic mechanisms allow a better understanding of current prevention strategies. Written by leading experts, this volume of Monographs in Virology provides up-to-date information on the prevention of papillomavirus-induced cancers by prophylactic antiviral vaccines and early detection of precancerous lesions.A major section covers the tremendous clinical burden due to HPV infections: genital warts and laryngeal papillomas, the most notorious cervical cancer, but also further anogenital and tonsillar cancer, the incidence of which increased steeply during the last decades. Additionally, a section on prevention addresses the subject cytology - new concepts of biomarker development, detection of HPV DNA and RNA as well as their use in primary screening for early detection of precancerous lesions. Finally the book closes with a topical discussion of the most intriguing primary prevention of HPV infection by vaccination.As new perspectives for the prevention of HPV-related neoplasia raised great public interest, this book will be of value to clinicians and practitioners in gynecology, dermatology, urology and ENT, to pathologists, laboratory physicians, medical students, and public health authorities.

Chapter

Foreword

Reference

Virology and Pathogenesis

Abstract

Virion Structure and Genome Organization

Classification

Viral Life Cycle

Pathogenesis

High-Risk Human Papillomaviruses Differ in Oncogenic Potential

References

Epidemiology of Mucosotropic Papillomaviruses

Abstract

Transmission

Progression

Human Papillomavirus and Other Malignant Tumors

References

Clinical Aspects of Low-Risk HPV Infections

Condylomata Acuminata

Abstract

Epidemiology/Natural History

Clinical Manifestation of Genitoanal Warts in Adults

Genitoanal Warts in Children

Diagnosis of Genitoanal Warts

Clinical Course and Burden of Disease

Treatment

Modes of Treatment and Recommended Therapies

Therapies Not Currently Recommended

Prevention

References

Recurrent Respiratory Papillomatosis

Abstract

Epidemiology

Etiology

Clinical Features

Surgery Treatment

Adjuvant Treatment

Prevention

References

Clinical Aspects of High-Risk HPV Infections

Cervical Cancer and Intraepithelial Neoplasia

Abstract

Incidence

Age Distribution

Etiology and Pathogenesis

Natural Course of Human Papillomavirus Infections

Additional Risk Factors

Primary and Secondary Prevention

Premalignant Disease

Invasive Disease

Cervical Cancer in Pregnancy

Adnexae

Recurrence

Metastasizing Disease

Follow-Up

References

Cancer and Intraepithelial Neoplasia of the Vulva and Vagina

Abstract

Vulval Neoplasia

Vaginal Neoplasia

References

Penile Cancer and Penile Intraepithelial Neoplasia

Abstract

Penile Intraepithelial Neoplasia

Penile Cancer

References

Anal Cancer and Intraepithelial Neoplasia

Abstract

Human Papillomavirus Type Distribution in Anal Intraepithelial Neoplasia and Anal Cancer

Incidence and Prevalence of Anal Intraepithelial Neoplasia and Anal Cancer

Diagnosis of Anal Intraepithelial Neoplasia and Anal Cancer

Treatment and Prevention of Anal Intraepithelial Neoplasia and Anal Cancer

References

Tonsillar Cancer

Abstract

Epidemiology

Clinical Features

Histopathology/Molecular Pathology

Therapy and Prognosis

References

Diagnosis for Early Detection

Cytology

Abstract

Background/Conventional Cytology

Liquid- Based Cytology

Computer Assistance

Perspectives

References

Concepts of Biomarker Development

Abstract

Basic Pathogenesis of Human Papillomavirus Infections and Its Impact on Biomarker Identification

Biomarkers for Different Stages of Human Papillomavirus Infections

Conclusions

References

Detection of Human Papillomavirus DNA and RNA

Abstract

Background

Methods of Human Papillomavirus Detection

Polymerase Chain Reaction

Signal Amplification

The Central Role of Specificity

A Guideline for New Human Papillomavirus Tests

New Commercial Human Papillomavirus Tests

Human Papillomavirus Genotyping

Human Papillomavirus RNA Testing

References

Human Papillomavirus Testing in Primary Screening for Cervical Cancer

Abstract

What Is the Best Screening Test?

Why Has Human Papillomavirus Screening Not Yet Replaced Pap Smear Screening?

Outlook

References

Primary Prevention by Vaccination

Abstract

Development of Prophylactic Human Papillomavirus Vaccines

Clinical Studies

Further Developments

References

Author Index

Subject Index

Cover

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