Publisher: Bentham Science Publishers
E-ISSN: 1875-5704|15|4|576-584
ISSN: 1567-2018
Source: Current Drug Delivery, Vol.15, Iss.4, 2018-04, pp. : 576-584
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Methods: Ultrasonication was introduced into the process to obtain micro/nanoscale SLs. The mechanismof dissolution enhancement was investigated by analysing the crystalline structure, molecularinteractions, and particle size of the formulations. Results: The drug release from the SD-SLs was significantly greater than that from the SD or SLsalone. This enhancement in drug release was dependent on the preparation method and the drug-topolymerratio of the SD. With an appropriate amount of polymer in the SD, the solidification methodhad the potential to alter the drug crystallinity to an amorphous state, resulting in particle uniformityand molecular interactions in the SD-SLs. Conclusions: The proposed system provides a new strategy for enhancing the dissolution rate of poorlywater-soluble drugs and further improving their bioavailability.
Related content
By Joshi H.N. Tejwani R.W. Davidovich M. Sahasrabudhe V.P. Jemal M. Bathala M.S. Varia S.A. Serajuddin A.T.M.
International Journal of Pharmaceutics, Vol. 269, Iss. 1, 2004-01 ,pp. :
By Papadimitriou Sofia Bikiaris Dimitrios
Drug Development and Industrial Pharmacy, Vol. 35, Iss. 9, 2009-09 ,pp. :
By Maniruzzaman M. Rana M. M. Boateng J. S. Mitchell J. C. Douroumis D.
Drug Development and Industrial Pharmacy, Vol. 39, Iss. 2, 2013-02 ,pp. :