Encapsulation of Solid Dispersion in Solid Lipid Particles for Dissolution Enhancement of Poorly Water-Soluble Drug

Publisher: Bentham Science Publishers

E-ISSN: 1875-5704|15|4|576-584

ISSN: 1567-2018

Source: Current Drug Delivery, Vol.15, Iss.4, 2018-04, pp. : 576-584

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Abstract

Background: The aim of this research was to engineer solid dispersion lipid particles (SDSLs)in which a solid dispersion (SD) was encapsulated to form the core of solid lipid particles (SLs),thereby achieving an efficient enhancement in the dissolution of a poorly water-soluble drug.

Methods: Ultrasonication was introduced into the process to obtain micro/nanoscale SLs. The mechanismof dissolution enhancement was investigated by analysing the crystalline structure, molecularinteractions, and particle size of the formulations.

Results: The drug release from the SD-SLs was significantly greater than that from the SD or SLsalone. This enhancement in drug release was dependent on the preparation method and the drug-topolymerratio of the SD. With an appropriate amount of polymer in the SD, the solidification methodhad the potential to alter the drug crystallinity to an amorphous state, resulting in particle uniformityand molecular interactions in the SD-SLs.

Conclusions: The proposed system provides a new strategy for enhancing the dissolution rate of poorlywater-soluble drugs and further improving their bioavailability.

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