An Overview on Chemistry and Biological Importance of Pyrrolidinone

Publisher: Bentham Science Publishers

E-ISSN: 1875-6271|15|2|166-178

ISSN: 1570-1794

Source: Current Organic Synthesis, Vol.15, Iss.2, 2018-04, pp. : 166-178

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Abstract

Background: Pyrrolidinone is a five membered heterocyclic ring that is a versatile lead compoundfor designing powerful bioactive agents. Pyrrolidinone nucleus is one of the most important heterocyclic compoundindicating notable pharmaceutical effects. Many procedures for the preparation of pyrrolidinone andalso their various reactions offer great scope in the field of medicinal chemistry. This fascinating group ofcompounds has diverse pharmacological activities such as antibacterial, antifungal, anticancer and anticonvulsant.

Objective: The review article proposes to classify comprehensive information on chemistry and pharmaceuticaleffects of pyrrolidinone in order to open new viewpoint for future studies.

Conclusion: It is clear from the review of the topic that a wide spectrum of pyrrolidinone analogues have beensynthesized and the majority of these derivatives have indicated different significant biological activities. Thus,these analogues can be used for future progression of novel drugs against many more poor agents.