The Epigenetic Regulation in Tooth Development and Regeneration
Publisher:
Bentham Science Publishers
E-ISSN:
2212-3946|13|1|4-15
ISSN:
1574-888x
Source:
Current Stem Cell Research & Therapy,
Vol.13,
Iss.1, 2018-01,
pp. : 4-15
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Previous
Menu
Next
Abstract
Background: Tooth loss occurs with age and significantly impacts the quality of elderly'slife both physically and psychologically. It has been well known that odontogenesis is a complicatedprocess with sequential and reciprocal interactions between epithelial and mesenchymal tissues anddifferent types of dental tissue-derived stem cells involve in it. However, only a small portion of theintricate mechanisms has been defined nowadays. Among them, epigenetics has become an increasinglyimportant mechanism for tooth development and regeneration.Objective: This review aims at illustrating the function of epigenetic regulation in odontogenesis, whichplays an important role in dental tissue-derived stem cell self-renewal and differentiation nowadays andwould be a new strategy for tooth regeneration.Results: In this review, we introduced the natural process of tooth development and the functions ofstem cells involved in. Furthermore, we summarized the current knowledge on epigenetic regulationincluding DNA methylation, histone modification, and non-coding RNAs during odontogenesis, providingthe theoretical basis for tooth regeneration.Conclusion: Along with a deeper understanding of odontogenesis, the epigenetic mechanism involvedin has become increasingly important. Therefore, it`s necessary to further study the functions of epigeneticregulation in tooth development and regeneration, which may make tooth regeneration a reality inthe future.