Experimental Mouse Models of Thrombosis Optimized for Drug Discovery and Development

Publisher： Bentham Science Publishers

E-ISSN： 1875-628x|2|5|403-411

ISSN： 1570-1808

Source： Letters in Drug Design & Discovery, Vol.2, Iss.5, 2005-08, pp. : 403-411

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Abstract

Animal models of diseases are essential for drug discovery and development. The availability of a large number of genetically-manipulated mice renders considerable interest in drug discovery by means of experimental models of disease. Ferric chloride-induced thrombosis is one of the most commonly used experimental models of thrombosis in mice. This review provides examples of optimizing this arterial thrombosis model for target validation and drug discovery in mice.

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