Evaluation of Novel 7-(hetero)aryl-substituted Pyrazolo[1, 5-a]pyrimidines as Phosphodiesterase-4 Inhibitors

Publisher: Bentham Science Publishers

E-ISSN: 1875-628x|7|6|402-408

ISSN: 1570-1808

Source: Letters in Drug Design & Discovery, Vol.7, Iss.6, 2010-07, pp. : 402-408

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Abstract

A novel series of 7-(hetero)aryl substituted-pyrazolopyrimidines, prepared via an AlCl3 induced C-C bond forming reaction of 7-chloro-5-phenyl-pyrazolo[1,5-a]pyrimidine with arenes and heteroarenes have been investigated as PDE4 inhibitors. Among all the compounds tested the 7-indolyl substituted pyrazolopyrimidine showed good inhibition of PDE 4 in vitro.