Prognosis of Possible Reassortments in Recent H5N2 Epidemic Influenza in USA: Implications for Computer-Assisted Surveillance As Well As Drug/Vaccine Design

Publisher： Bentham Science Publishers

E-ISSN： 1875-6697|11|2|110-116

ISSN： 1573-4099

Source： Current Computer - Aided Drug Design, Vol.11, Iss.2, 2015-09, pp. : 110-116

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Abstract

The recent H5N2 flu epidemic in US Midwest has led to deaths of millions ofturkeys and farm bred poultry. While no human infections are reported to date, the rapidmutations in flu viruses can lead to more pathogenic subtypes. We have investigated suchpossibilities and have shown that H5N4, H5N9 and H5N6 are the most likely candidatesfor next round of viral reassortments, amongst which H5N9, if reassorted from Asiatic strains, could be highly pathogenic.We discuss here possibilities of anticipatory rational vaccine design based on work done earlier.

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