Rapid and Efficient One-Pot Synthesis of 3,4-Dihydroquinoxalin-2-Amine Derivatives Catalyzed by Co₃O₄@SiO₂ Core-Shell Nanoparticles Under Ultrasound Irradiation

Publisher： Bentham Science Publishers

E-ISSN： 1875-5402|19|7|592-601

ISSN： 1386-2073

Source： Combinatorial Chemistry & High Throughput Screening, Vol.19, Iss.7, 2016-07, pp. : 592-601

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Abstract

In this research, a general synthetic method for the synthesis of 3,4-dihydroquinoxalin-2-amine derivatives was developed using Colt;subgt;3lt;/subgt;Olt;subgt;4lt;/subgt;@SiOlt;subgt;2lt;/subgt;nanoparticles under ultrasonic irradiation. Firstly by a simple and green process,Colt;subgt;3lt;/subgt;Olt;subgt;4lt;/subgt;@SiOlt;subgt;2lt;/subgt; nanoparticles were prepared via sonication, and then thesenanoparticles were used as an efficient catalyst for the synthesis of 3,4-dihydroquinoxalin-2-amines via three-component reactions of ophenylenediamines(OPDA), diverse ketones and various isocyanides in ethanolunder ultrasound irradiation. The combinatorial synthesis was attained for thisprocedure with applying ultrasound irradiation while making use of ethanol asgreen ambient. The present approach offers several advantages such as highyields, environmentally benign, simple work-up, excellent yield of products and short reactiontimes. The nanomagnetic catalyst could be readily recovered using a simple external magnet andreused several times without any significant loss in activity. The catalyst was fully characterized byFT-IR, FE-SEM, XRD, EDX, VSM and TEM analysis.