The Clinical Role of N-acetylcysteine in the Management of COPD: A Review of Recent Literature

Publisher： Bentham Science Publishers

E-ISSN： 1875-6387 |12|2|136-141

ISSN： 1573-398x

Source： Current Respiratory Medicine Reviews, Vol.12, Iss.2, 2016-07, pp. : 136-141

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Abstract

Currently, bronchodilators are the mainstay treatment of stable chronic obstructivepulmonary disease while systemic corticosteroids and antibiotics have a major role in COPD acuteexacerbations. Inhaled N-acetylcysteine is a mucolytic that has a pharmacologic role in respiratoryconditions associated with excessive thick mucus production. Additionally, N-acetylcysteine hasbeen studied as an adjunct agent for the clinical management of COPD because of its antioxidant andinflammatory properties. This paper provides a narrative review of literature on the effect Nacetylcysteinehas on clinical outcomes in stable COPD and in acute COPD exacerbations. Primaryliterature was sought utilizing databases using Medline (2004-present). The database was searchedusing the key MeSH terms N-acetylcysteine and COPD, COPD exacerbation.lt;/pgt

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