Homology Modeling Inspired Synthesis of 5-HT2A Receptor Inhibitors: A Diazepine Analogue of the Atypical Antipsychotic JL13

Publisher: Bentham Science Publishers

E-ISSN: 1875-6166|17|3|239-244

ISSN: 1871-5249

Source: Central Nervous System Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Central Nervous System Agents), Vol.17, Iss.3, 2017-10, pp. : 239-244

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Abstract

Background: The benzoxazepine JL13 is an analogue of the clozapine family of antipsychoticagents which target the 5-HT2A receptor, and has showed promise as an atypical antipsychoticagent. Based on the dearth of clinically effective anti-psychotic agents available, we sought todesign and chemically synthesize additional analogues.lt;/Pgt

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