Potential of Plant Alkaloids as Antipyretic Drugs of Future

E-ISSN： 1875-5453|18|2|138-144

ISSN： 1389-2002

Source： Current Drug Metabolism, Vol.18, Iss.2, 2017-03, pp. : 138-144

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Abstract

Fever or Pyrexia means abnormal rise in body temperature above the usual range of normal in response to avariety of infectious, immunological and neoplastic stimuli. To normalize these febrile conditions, several syntheticagents are in clinical practice such as acetaminophen, ibuprofen, and aspirin. However, they are having many sideeffects which sometimes challenge their applications. The various sources are under investigation worldwide to overcomeissues of unwanted effects and to better therapeutic response. In this scenario botanicals such as alkaloids, themost widely distributed and studied plant secondary metabolites, could effectively produce the molecules with betterantipyretic effect and safety profile. The current review deals with 21 isolated alkaloids from 14 plants species havingsome antipyretic effect in preliminary screening/preclinical studies with the possible mechanism and structural edges.Therefore, these alkaloids of plant origin are candidates for further detail studies to ascertain their mechanism(s) andclinical utility or as lead compounds for future drugs.