Practical and Green Process for the Synthesis of Ivabradine Hydrochloride Through an Efficient Control of Process Impurities

Publisher： Bentham Science Publishers

ISSN： 2213-3461

Source： Current Green Chemistry, Vol.4, Iss.3, 2018-01, pp. : 151-160

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Abstract

Background: Synthetic processes reported for ivabradine hydrochloride (1), a heart rate loweringdrug (an antianginal agent), are inefficient and uneconomical at an industrial scale due to their inabilityto control the formation of process related impurities. Generation of huge amount of solvent andsolid waste due to repeated purifications and/or chromatographic purifications to eliminate impuritiesmakes them industrially unsuitable hence requires the development of practical and greener process for 1.lt;/Pgt

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