TiO2-based Mitoxantrone Imprinted Poly (Methacrylic acid-co-polycaprolctone diacrylate) Nanoparticles as a Drug Delivery System

Publisher: Bentham Science Publishers

E-ISSN: 1873-4286|23|18|2685-2694

ISSN: 1381-6128

Source: Current Pharmaceutical Design, Vol.23, Iss.18, 2017-07, pp. : 2685-2694

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Abstract

Background: Light delivery in photodynamic therapy is a challenging issue in deep cancer treatment.To solve this problem, photosensitizers are conjugated to X-ray luminescent nanoparticles. When the complexesare stimulated by X-rays during radiotherapy, the nanoparticles generate light and activate the photosensitizers.Method: Core-shell molecularly imprinted polymers (MIPs) were prepared against mitoxantrone (MX) in whichTiO2 nanoparticles were applied as a core, diacrylated polycaprolctone as a biodegradable cross-linker andmethacrylic acid (MAA) or 4-vinylpyridin (4-VP) as the functional monomer. TiO2 was selected as a scintillator,MX as a photosensitizer and MIP as a drug delivery system in order to evaluate the possibility of using photodynamictherapy (PDT) during radiotherapy in the next studies. Binding properties of polymers and drug releaseprofile were studied and the optimized MIP was characterized by SEM, TEM, EDS, FT-IR and XRD. Also, cytotoxicityand free radical production were also studied in vitro.Results: Data indicated that MAA-based MIP had superior binding properties compared to its non-imprintedpolymer (NIP) and higher imprinting factor value than MIP-4VP. Drug release experiments indicated higher MXreleased amount from MAA-based MIP than the other polymers. MAA-based MIP was selected as an optimizedcarrier for MX delivery system. According to the results, the size of MX-MIP@TiO2 was reported to be less than75 nm. The free radical production and cytotoxicity of nanoparticles were also evaluated in vitro.Conclusion: The results of the present work proposed the possibility of applying MIP layer as a drug deliverysystem around TiO2 nanoparticles.