Synthesis and Activity of Epothilone D

Publisher: Bentham Science Publishers

E-ISSN: 1873-5592|19|15|1866-1870

ISSN: 1389-4501

Source: Current Drug Targets, Vol.19, Iss.15, 2018-12, pp. : 1866-1870

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Abstract

Epothilones are a class of macrolide compounds. Their activities of tubulin polymerizationand microtubule depolymerization inhibition like paclitaxel make them a new generation of antimitoticdrugs. The mechanism of action is similar to that of paclitaxel, which can bind to tubulin andcause cancer cells to fail to undergo mitosis, thereby causing apoptosis in cancer cells. Epothilone issuperior to paclitaxel in anti-tumor spectrum, anti-tumor activity, safety, water solubility and syntheticmethods. It is expected to develop into a more effective anti-tumor drug than paclitaxel. Herein, thesynthesis methods and activity of epothilone D were summarized and analyzed.