Neuroblastoma Research Trends

Author: Lucas H. Andre and Nathan E. Roux  

Publisher: Nova Science Publishers, Inc.‎

Publication year: 2013

E-ISBN: 9781616680978

P-ISBN(Hardback):  9781604567908

Subject: R3 Basic Medical

Keyword: Bio-Medical

Language: ENG

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Neuroblastoma Research Trends

Chapter

Diagnostic Implications of CSCs in NB

Oncogenic Implications of CSCs in NB: Development and Cancer

Future Directions: Cancer Stem Cells and Stem Cell Niche

References

Chapter II: Perspectives of Proteomics Investigations of Neuroblastoma Chemoresistance

Abstract

Introduction

Distinct Cell Type of Neuroblastoma

Cancer Chemoresistance

Cell Line Variants as in Vitro Model

Human Neuroblastoma Characterization by Proteomic Approach

Drug Response Investigations

Conclusions

References

Chapter III: Down Syndrome's Protection Against Neuroblastoma: The Stromal and Neural Overmaturation Tracks

Abstract

Introduction

Neuroblastoma Occurs Exceptionally in Children with DS

Analysis of the Cases of Neuroblastic Tumors Reported in Infants and Children with DS

Aspects of Adrenal Medulla in DS

Genes on Chromosome 21 which could Protect Against Neural Cancer and Particularly Neuroblastoma

Personal data: 1. S100 B inHibits the Growth of Neuroblastoma Cell Lines in Vitro and in Vivo

Personal Data: 2. PCP4 Induces Earlier Neuroblastoma Differentiation

Personal Data: 3 Trisomic 21 Fibroblast Extra Cellular Matrix Inhibits the Growth of Neuroblastoma Cell Lines

A Protective Effect of Neural Cell Differentiation and Extra Cellular Medium?

Conclusion

Acknowledgments

References

Chapter IV: The p73 Target Genes in Human Malignant Neuroblasts are Related to Neuronal Development and Sympathetic Differentiation

Abstract

Abbreviations

1. Introduction

2. Identification and Classification of p73 -Target Genes

3. Analysis of Genes Induced by Adenoviral TAp73 or Np73 Expression in NB Cells

4. p73 Expression is Strongly Induced during Human NB Differentiation by Retinoic Acid

5. Conclusion

Reference List

Chapter V: The Relationships are between the Neuroblastome and Caspases 3, 8,9

Reference

Chapter VI: Genome and Proteome in Neuroblastoma

Introduction Genome in Neuroblastoma

From Genome to Proteome

Gene and Protein Microarray Analysis

Proteomic Markers in Neuroblastoma

Conclusion

References

Index

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