STEM CELLS CELLULAR AND DRUG THERAPIES VOLUME 2

STEM CELLS CELLULAR AND DRUG THERAPIES VOLUME 2

Library of Congress Cataloging-in-Publication Data

Contents

Introduction

Aneuploidy and Adult Neurogenesisin Alzheimer’s Disease: Therapeutic Strategies

Acknowledgments

References

Chapter 1 Adult Neurogenesis in Etiology and Pathogenesis of Alzheimer’s Disease

Abstract

Introduction

Alzheimer’s Disease

Adult Neurogenesis and Neural Stem Cells

Adult Neurogenesis in Alzheimer’s Disease

Aneuploidy and Aneuploid Newly Generated Neuronal Cells

Conclusion and Perspectives

Acknowledgments

References

Chapter 2 Adult Neurogenesis and Aneuploidy in Etiology, Pathogenesis and Pathology of Alzheimer’s Disease

Abstract

Introduction

Amyloid Plaques, Neurofibrillary Tangles and Causative Factors of Alzheimer’s Disease

Aneuploidy in Alzheimer’s Disease

Adult Neurogenesis and Neural Stem Cells

Neurogenesis and Aneuploid Newly Generated Neuronal Cells in Alzheimer’s Disease

Conclusion and Perspectives

References

Chapter 3 Adult Neurogenesis, Neural Stem Cells and Alzheimer’s Disease: Developments, Limitations, Problems and Promise

Introduction

Alzheimer’s Disease Pathology and Pathogenesis

Discussion

Conclusion and Perspectives

References

Chapter 4 Oxidative Stress in Adult Neurogenesis and in the Pathogenesis of Alzheimer’s Disease

1. Introduction

2. Alzheimer Disease

3. Adult Neurogenesis and Enhanced Neurogenesis in Alzheimer Disease

4. Oxydative Stress: A Risk Factor for Developing Alzheimer Disease

Conclusion

Acknowledgments

References

Chapter 5 Adult Neurogenesis, Neuroinflammation, and Therapeutic Potential of Adult Neural Stem Cells

Abstract

Introduction

Neurogenesis and Neural Stem Cells in the Adult CNS

Adult Neurogenesis in Neurological Diseases and Disorders

Depression

Epilepsy

Therapeutic Potential of Adult Neural Stem Cells

Neuroinflammation and the Therapeutic Potential of Adult NSCs

Conclusion and Perspectives

Acknowledgments

References

Chapter 6 Adult Neurogenesis and Drug Therapy*

Introduction

Neurogenesis in the Adult Mammalian Brain

Neurogenesis and Neurological Diseases, Disorders and Injuries

Discussion

Conclusion

References

Chapter 7 Neurogenesis and the Effect of Antidepressants

Abstract

1. Introduction

2. Neurogenesis Contributes to the Therapeutic Effects of Antidepressants

3. A Neurogenic Theory of Depression

Conclusion

Acknowledgments

References

Chapter 8 Neurogenic Drugs and Compounds to Treat CNS Diseases and Disorders*

Abstract

Paradigms and Strategies

Drug Target

Identified and Characterized Neurogenic Drugs and Compounds

Problems to Overcome

References

Chapter 9 Patent Evaluation: Thirteen Compounds Promoting Oligodendrocyte Progenitor CellDifferentiation and Remyelination for Treating Multiple Sclerosis: Wo2010054307

Abstract

1. Introduction

2. Chemistry and Synthesis

3. Biology and Action

4. Expert Opinion

Declaration of Interest

Acknowledgments

References

Chapter 10 Patent Evaluation: Antibodies against CD20 (Rituximab) for Treating Multiple Sclerosis: US20100233121

Abstract

1. Introduction

2. Chemistry and Synthesis

3. Biology and Action

4. Expert Opinion

Declaration Of Interest

Acknowledgments

References

Chapter 11 Umbilical Cord Blood and Alpha-3Fucosyl Transferase-Treated Haematopoietic Stem Cells for Transplantation

Abstract

Introduction

Transplantation of Umbilical Cord Blood for Treating Haemetologic Diseases

Transplantation of Double Dose of Umbilical Cord Blood

Homing of Haemetopoietic Stem Cells to the Bone Marrow

Fucosylation of Umbilical Cord Blood Ex Vivo

Conclusion

Acknowledgments

References

Chapter 12 Patent Evaluation: Cell Lines Expressing MutantFX Proteins to Generate Proteins with Reduced Rate of Fucosylation: Wo2010/141478

Abstract

1. Introduction

2. Chemistry and synthesis

3. Biology and Action

4. Expert Opinion

Acknowledgments

References

Chapter 13 Patent Evaluation: Modulation of GDP-Fucose Level for Generating Proteins with Reduced Rate of Fucosylation (Wo2010141855)

Abstract

1. Introduction

2. Chemistry and Synthesis

3. Biology and Action

4. Expert Opinion

Acknowledgments

References

Chapter 14 Patent Evaluation: Chimeric Proteins Comprising the Constant Region of Immunoglobulins for Treating Haemophilia B(WO2005001025)

Abstract

1. Introduction

2. Chemistry and Synthesis

3. Biology and Action

4. Expert Opinion

Acknowledgments

References

Chapter 15 Patent Evaluation: Parthenogenetically Activated Human Oocytes and Parthenogenetic Embryonic Stem Cells: US20100233143

Abstract

1. Introduction

2. Chemistry and Synthesis

3. Biology and Action

4. Expert Opinion

Acknowledgments

References

Chapter 16 Tuberous Sclerosis Complex: A Paradigm for Studying Adult Neurogenesis and Brain Tumors

Abstract

Introduction

Tuberous Sclerosis Complex

TSC Genes, Hamartin, and Tuberin

Conclusion

Acknowledgments

References

Chapter 17 Adult Neurogenesis in Alzheimer’s Disease and Therapies

Abstract

Introduction

Alzheimer’s Disease

Adult Neurogenesis and Neural Stem Cells in Mammals

Adult Neurogenesis and Newly Generated Neuronal Cells in AD

Cellular Therapy

Conclusion and Perspectives

Acknowledgments

References

Chapter 18 Indacaterol for the Treatment of Patients with Moderate-to-Severe COPD

References

Conclusions

Conclusion 1

Neurogenic Drugs for Treating NeurologicalDiseases and Disorders

Acknowledgments

References

Conclusion 2

Bromodeoxyuridine Labeling:Beware of the Limitations and Pitfalls

Acknowledgments

References

Index