Chapter
Chapter 3: Genetics of Medulloblastoma
When Our Cerebellum is Developing Normally…
1. Embryonic Cerebellar Development: The Rhombic Lip and Cerebellar Radii
2. Postnatal Cerebellar Development: CGNP Proliferation and Migration
When Cerebellar Tumorigenesis Sets In…
1. Medulloblastoma Histopathology
2. Molecular Characterization of Medulloblastoma: Genetics, Cytogenetics and Epigenetics
Chapter 4: Imaging of Medulloblastoma
Department of Radiology, University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, Texas, US
Chapter 5: Surgical Treatment of Medulloblastoma
Preoperative Evaluation and Treatment Strategies
Operative Positioning of Patient
Intraoperative and Postoperative
Chapter 6: Radiotherapy in the Management of Medulloblastoma
General Principles of Pediatric Radiotherapy for Central Nervous System Tumors
Craniospinal Irradiation for Medulloblastoma
Role of Radiotherapy in Medulloblastoma
Delivery of Treatment for Craniospinal Irradiation
Patient Preparation (Mould Room / Planning CT)
Outline and Target Volume Definitions
Phase I: Craniospinal Irradiation
Phase II: Posterior Fossa / Tumor Bed Definition
Pattern of Relapse in Medulloblastoma
Role of Radiotherapy in Recurrent Medulloblastoma
Chapter 7: Toxicity of Radiotherapy in the Treatment for Medulloblastoma
Focal Neurologic Symptoms
Reducing Radiation Injury
Chapter 8: Chemotherapy of Medulloblastoma
Treatment of Average-Risk Disease
Treatment of High-Risk Disease
Treatment of Infants with Medulloblastoma
Recurrent and Resistance Disease
Side Effects of Chemotherapy
Chapter 9: Metastatic Medulloblastoma: Clinical and Biological Insights
Current Treatment Protocols
Genomics of Metastatic Medulloblastoma
Primary and Metastatic Compartments Are Genetically Distinct
Chapter 10: Intra-Cerebrospinal Fluid Therapy for Leptomeningeal Metastases in Medulloblastoma
Prevalence, Diagnosis and Staging of Leptomeningeal Disease
Leptomeningeal Metastases Directed Therapy
Blood-brain-Barrier and Blood-CSF-Barrier
LM Targeted Treatment Modalities in Medulloblastoma
Cranio-spinal Radiotherapy
Intra-CSF administration of Chemotherapy
Criteria for Drug Selection of intra-CSF Administered Therapy
Neurotoxicity, Systemic Toxicity and Infectious Risk
Outcome of intra-CSF Administered Drugs
Modes of Delivery Intra-CSF administered Therapy
Bolus versus Sustained Release
Improving Feasibility of Intra-CSF Drug Administration
Pharmacokinetic Optimisation of Drug Dosing
Developing New Drugs for Intrathecal Use
Chapter 11: Outcome and Long-Term Complications
Safety of Hormone Replacement in Children Treated for Brain Tumors
Molecular Basis of GH Oncogenic Potential
Oncologic Risk in Patients with Tumors
GH Therapy and Radiological Findings in Patients Treated for Brain Tumors
Possible Morbidity Prevention
Central Adrenal Insufficiency
Overweight/Obesity, Dyslipidemia and Metabolic syndrome
Endocrine Sequelae after Radiotherapy Plus High Doses Chemotherapy
Brain Magnetic Resonance Imaging after High Dose Chemotherapy and Radiotherapy
Chapter 12: Medulloblastoma in Developmental Age: Long-Term Neurocognitive and Emotional-Behavioral Outcome
The Roles of Surgery and Tumor Location
The Third Set Variables Concern Cognitive Reserve and Rehabilitation
Chapter 13: Neurocognitive Sequelae: Personal Experiences
Chapter 14: Medulloblastoma in Adulthood
Epidemiology and Clinical Presentation
Radiation-induced adult MB
Quality of Life for Survivors
Molecular Features and Biology
Are Childhood and Adult MB Different?
Chapter 15: Novel Therapies and Next Generation Clinical Trials in Medulloblastoma
The Genomic Landscape of Medulloblastoma
Advances in Medulloblastoma Clinical Trials
Recurrent Medulloblastoma
Emerging Targeted Therapies in Medulloblastoma
The Medulloblastoma Book
( Neuroscience Research Progress )
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