ACUTE LUNG INJURY: EPIDEMIOLOGY, HEALTH EFFECTS AND THERAPEUTIC TREATMENT STRATEGIES

ACUTE LUNG INJURY: EPIDEMIOLOGY, HEALTH EFFECTS AND THERAPEUTIC TREATMENT STRATEGIES

Library of Congress Cataloging-in-Publication Data

Contents

Preface

Chapter 1: TRALI Not a Two Hit, But a Multi-Causal Model

Center for Clinical Transfusion Research, Sanquin Research, Leiden; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

Abstract

Introduction

Threshold Models

A More General Threshold Model of Multi-Causality

The Sufficient Cause Model

Discussion

Conclusion

References

Chapter 2: Mechanisms and Prevention of Pulmonary Microvascular Hyperpermeability in Acute Lung Injury

Abstract

Introduction

Pulmonary Microvascular Hyperpermeability

in Acute Lung Injury

The Mechanisms of Pulmonary Microvascular Hyperpermeability in Acute Lung Injury

Macrophages

Neutrophils

Platelets

Cell Organelles

Small G Protein

Calcium

HMGB1

Cell Junctions

Nitric Oxide (NO) and Inducible Nitric Oxide Synthase (iNOS)

Focal Adhesions (FAs) Complex and FA Kinase (FAK)

Hyperoxia

Prospective Approach to Heal ALI

References

Chapter 3: Pharmacological Therapies for Acute Respiratory Distress Syndrome

Abstract

Introduction

Corticosteroids

Neutrophil Elastase Inhibitors

Anticoagulant Therapies

Conclusion

References

Chapter 4: Novel Trends in Pharmacotherapy of Acute Lung Injury and Acute Respiratory Distress Syndrome

ABSTRACT

Definition of ALI/ARDS

Pathophysiology of ALI/ARDS as a Rationale for the Treatment

Pharmacotherapy of ALI/ARDS

Types, Dosage and Delivery of Exogenous Surfactants

Effects of Surfactant Administration

Complications of Surfactant Administration

Surfactant Treatment in the Neonates and Children

Surfactant Treatment in the Adult Patients

Inhaled Nitric Oxide (iNO)

Aerosolized Prostacyclin

Non-conventional Approaches (Cell and/or Gene Therapy)

Cell-Based Approaches

Gene-Based Therapy

Cell-Delivered Gene Therapy

Conclusion

References

Editor Contact Information

Index