GLIOMAS: CLASSIFICATION, SYMPTOMS, TREATMENT AND PROGNOSIS

GLIOMAS: CLASSIFICATION, SYMPTOMS, TREATMENT AND PROGNOSIS

Library of Congress Cataloging-in-Publication Data

Contents

Preface

Chapter 1: Classification, Histology, Genomic Alterations and New Therapeutic Concepts

Abstract

Gliomas Histology and Grading

Glioma Genomics

Loss of Heterozygosity in 1p and 19q

IDH1

EGFR

PDGF

PTEN

RB

P53

Treatment

Altered Immune System in Gliomas

Summary

Acknowledgments

References

Chapter 2: Brainstem Gliomas

Abstract

Introduction

Epidemiology

Classification

Pathology and Pathophysiology

Molecular Genetics

Clinical Presentation

Imaging Studies

Diagnosis and Differential Diagnosis

Treatment

Outcomes

Recent Advances and Future Directions

Conclusion

References

Chapter 3: Pediatric Gliomas: Classification, Biology, Treatment and Prognosis

Abstract

Introduction

Conclusion

References

Chapter 4: Minimally Invasive Techniques for the Surgical Treatment of Glioma

Abstract

Surgical Goals

Pre-Operative Planning

Surgical Approach

Intraoperative Tools

Intraoperative Imaging

Complication Avoidance

Conclusion

Acknowledgments

References

Chapter 5: Advances in Targeted Radiation Therapy for High-Grade Gliomas

Abstract

Introduction

Identifying the Target

Delivering Dose to the Target

Conclusion

References

Chapter 6: PET Tracers in Glioma Imaging

Abstract

PET Tracers in Glioma Imaging

Conclusion

References

Chapter 7: The Role of Genomic Instability and Tumor Suppressors’ Alterations in Glioma Pathogenesis

Abstract

Introduction

Histopathological Characterization of Gliomas

Molecular Genetics of Malignant Gliomas

Tumor Heterogeneity and Genomic Instability in GBM

The Role of Tumor Suppressor Gene Alterations in GBM

Conclusion

References

Chapter 8: Signaling Pathways and Therapeutic Targets in GBM

Abstract

Abbreviations

Introduction

Tyrosine Kinases in GBM

Signal Transduction Pathways

Current Treatment Options for Glioblastoma

Conclusion

References

Chapter 9: Identification of a Potent Antiglioma Agent from Pre-Clinical Screening

Abstract

Introduction

Conclusion

Acknowledgment

References

Chapter 10: The Relationship between P53-ROS Pathway and Programmed Cell Death in C6 Glioma Cells

Abstract

Abbreviations

Introduction

NAC Induces Apoptosis and Necrosis in C6 Glioma Cells

P53 Participates in the Regulation of Necrosis in C6 Glioma Cells

ROS Participate in the Regulation of Necrosis in C6 Glioma Cells

Necrosis in C6 Glioma Cells Is Facilitated by P53-Mediated ROS Signaling

Conclusion

Conflict of Interest

Supplementary Material

Acknowledgments

References

Chapter 11: Nanoparticles and other Vectors for Delivering Targeted Therapeutics to Malignant Gliomas

Abstract

1. Introduction

2. Targeting Functional Molecules

3. Drug Delivery Vectors

Conclusion and Future Perspective

References

Index