GALACTOSE: STRUCTURE AND FUNCTION IN BIOLOGY AND MEDICINE

GALACTOSE: STRUCTURE AND FUNCTION IN BIOLOGY AND MEDICINE

Library of Congress Cataloging-in-Publication Data

CONTENTS

PREFACE

Chapter 1: GALACTOSE: CHEMICAL STRUCTURE, DIETARY SOURCES AND CLINICAL SIGNIFICANCE

ABSTRACT

INTRODUCTION

1. CHEMICAL STRUCTURE OF GALACTOSE

2. DIETARY SOURCES OF GALACTOSE

3. CLINICAL SIGNIFICANCE OF GALACTOSE

REFERENCES

Chapter 2: CLINICAL RELEVANCE OF GALACTOSE

ABSTRACT

INTRODUCTION

CONCLUSION

REFERENCES

Chapter 3: GALACTOSE: DIET AND ITS IMPLICATION IN GALACTOSEMIA

ABSTRACT

INTRODUCTION

GALT IMPAIRMENT

GALK IMPAIRMENT

GALE IMPAIRMENT

NATURAL SOURCES OF GALACTOSE AND DIET TO GALACTOSEMIC PATIENTS

GALACTOSE AND GALACTOSE-1-PHOSPHATE TOXICITY IN HUMANS VS. CONGENITAL DISORDERS

CURRENT THERAPEUTIC APPROACHES TO INBORN ERRORS OF GALACTOSE METABOLISM/INNOVATIVE THERAPY FOR CLASSIC GALACTOSEMIA

REFERENCES

Chapter 4: GALACTO-OLIGOSACCHARIDES RECENT PROGRESS ON RESEARCH AND APPLICATION AS PREBIOTICS

ABSTRACT

INTRODUCTION

PRODUCTION OF GALACTO-OLIGOSACCHARIDES

PROPERTIES AND BIOLOGICAL EFFECTS OF GALACTOOLIGOSACCHARIDES

EMERGING TRENDS IN THE PRODUCTION OF NOVEL HETERO-OLIGOSACCHARIDES

CONCLUSION

REFERENCES

Chapter 5: GALACTOSE CONFIGURATIONS IN NATURE WITH EMPHASIS ON THE BIOSYNTHESIS OF GALACTOFURANOSE IN GLYCANS

ABSTRACT

INTRODUCTION

UDP-GALACTOPYRANOSE MUTASE (UGM)

GALACTOFURANOSYLTRANSFERASES

UDP-GALACTOFURANOSE TRANSPORTER

CHEMICAL INHIBITION OF UGM

INHIBITORS OF UDP-GALFTRANSFERASES

CONCLUSION AND PERSPECTIVE

ACKNOWLEDGMENTS

REFERENCES

Chapter 6: REGULATION OF THE GALACTOSE OPERON IN E. COLI

ABSTRACT

INTRODUCTION

THE GAL OPERON

THE GAL OPERON PROMOTERS

CAMP-CRP EFFECT

GALR

THE GAL OPERATORS

DNA LOOPING

CO-FACTOR OF DNA LOOPING (HU)

HELICAL REQUIREMENT OF DNA LOOPING

REQUIREMENT OF SUPERCOILED DNA

USE OF ATOMIC FORCE MICROSCOPE (AFM)

ANTIPARALLEL VS. PARALLEL DNA LOOPING

INACTIVATION OF THE REPRESSOSOME

TRANSCRIPTION INITIATION

SINGLE DNA MOLECULE STUDIES

GALR-HU-CRP ACTIONS

GALS, AN ULTRAINDUCTION FACTOR

CONCLUSION

FUNDING

ACKNOWLEDGMENTS

REFERENCES

EDITOR CONTACT INFORMATION

INDEX