TROPONININ: FORMATIVE DIAGNOSTIC MARKER

TROPONIN: INFORMATIVE DIAGNOSTIC MARKER

Library of Congress Cataloging-in-Publication Data

CONTENTS

PREFACE

ACKNOWLEDGMENTS

LIST OF CONTRIBUTORS

Chapter 1: TROPONIN SUBUNITS: ISOFORMS, STRUCTURAL FEATURES, POSTTRANSLATIONAL MODIFICATIONS AND IMPACTS ON IMMUNOLOGICAL DETECTION

ABSTRACT

TROPONIN C

TROPONIN I

TROPONIN T

CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Chapter 2: THE EVOLUTION OF CARDIAC TROPONIN TESTING

ABSTRACT

ABBREVIATIONS

INTRODUCTION

A BRIEF HISTORY OF TROPONIN IMMUNOASSAYS

TECHNOLOGIES FOR TROPONIN IMMUNOASSAYS

ANALYTICAL CONSIDERATIONS

INTERPRETATION OF CARDIAC TROPONIN RESULTS

STANDARDIZATION AND HARMONIZATION

THE PATH FORWARD

CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Chapter 3: HOW TO USE HIGH-SENSITIVITY CARDIAC TROPONIN ASSAYS IN EVERYDAY CLINICAL PRACTICE

ABSTRACT

INTRODUCTION

DETECTION OF CARDIAC TROPONIN IN APPARENTLY PATHOLOGY FREE INDIVIDUALS

EARLY DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION

DISEASES WITH POTENTIAL HS-CTN ELEVATIONS OTHER THAN AMI

SUMMARY REGARDING THE USE OF HS-CTN ASSAYS IN EVERYDAY CLINICAL PRACTICE

DISCLOSURES

REFERENCES

Chapter 4: ADVANCED ELECTROCHEMICAL STRATEGIES FOR CARDIAC TROPONINS DETECTION

ABSTRACT

INTRODUCTION

CARDIAC TROPONIN DETECTION IN CLINICAL SAMPLES

CARDIAC TROPONIN I ELECTROCHEMICAL DETECTION

CARDIAC TROPONIN T ELECTROCHEMICAL DETECTION

MULTIPLEXED ELECTROCHEMICAL DETECTION OF CARDIAC TROPONIN BIOMARKERS

CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Chapter 5: UPDATE ON QUALITY SPECIFICATIONS FOR CARDIAC TROPONIN ASSAYS

ABSTRACT

1. INTRODUCTION

2. BIOCHEMICAL AND PATHOPHYSIOLOGY PROGRESS

3. GENERAL RECOMMENDATIONS ON PRE-ANALYTICAL AND ANALYTICAL FACTORS

4. POST-ANALYTICAL PHASE

CONCLUSION

DISCLOSURES

REFERENCES

Chapter 6: CARDIAC TROPONINS IN THE EVALUATIONOF MYOCARDIAL DAMAGE DURING PERCUTANEOUS CORONARY INTERVENTIONS

ABSTRACT

PERIPROCEDURAL DAMAGE: DEFINITIONS

MECHANISMS

MONITORING PCI-RELATED MYOCARDIAL DAMAGE: BIOCHEMICAL VS. IMAGING MODALITIES

CORRELATION BETWEEN PERI-PCI DAMAGE AND SURVIVAL

STRATEGIES TO REDUCE PERIPROCEDURAL DAMAGE

CLINICAL MANAGEMENT

CONCLUSION

REFERENCES

Chapter 7: POST-PROCEDURE TROPONIN ELEVATIONS IN ELECTIVE PERCUTANEOUS CORONARY INTERVENTION

ABSTRACT

INTRODUCTION

CONCLUSION

REFERENCES

Chapter 8: TROPONIN AS A MARKER OF CLINICALLY SIGNIFICANT MYOCARDIAL INJURY IN TRAUMA

ABSTRACT

INTRODUCTION

TROPONINS AND MYOCARDIAL CONTUSION

PEDIATRIC TRAUMA

LIMITATIONS OF TROPONIN MEASUREMENTS IN TRAUMA

CONCLUSION

REFERENCES

Chapter 9: TROPONIN AND ACUTE STROKE

ABSTRACT

1. INTRODUCTION

2. METHODS

3. TROPONINS

4. TROPONINS IN STROKE

5. MECHANISMS OF TROPONIN RISE IN ACUTE STROKE

6. TREATMENT IMPLICATIONS

CONCLUSION

REFERENCES

Chapter 10: INCREASED TROPONIN CONCENTRATION IN PRIMARY NON-CARDIAC DISEASES: CAUSES AND PROGNOSTIC SIGNIFICANCE

ABSTRACT

I. INTRODUCTION

II. CTN ELEVATION UNRELATED TO ACUTE CORONARY SYNDROME (ACS)

III. ORGAN-SPECIFIC CAUSES AND RELATED PROGNOSTIC SIGNIFICANCE

CONCLUSION

REFERENCES

INDEX