ADVANCES IN COGNITIVE AND BEHAVIORAL SCIENCES

ADVANCES IN COGNITIVE AND BEHAVIORAL SCIENCES

Library of Congress Cataloging-in-Publication Data

CONTENTS

PREFACE

Chapter 1 RELATIONSHIP BETWEEN VASCULAR RISK FACTORS AND MILD COGNITIVE IMPAIRMENT

ABSTRACT

1. INTRODUCTION

2. PREVALENCE OF MCI AND ASSOCIATION WITH STROKE RISK

3. IMPACT OF STROKE RISK FACTORS ON CONVERSION FROM MCI TO DEMENTIA

4. NEUROPSYCHOLOGY

5. ASSOCIATIONS BETWEEN STROKE RISK, NEUROIMAGING AND NEUROPATHOLOGY FINDINGS IN MCI

6. GENETIC CONTRIBUTIONS TO VASCULAR RISK AND MCI

7. METHODS FOR ASSESSMENT OF STROKE RISK

CONCLUSION

REFERENCES

Chapter 2 FAMILIARITY, ABSTRACTNESS, AND THE INTERPRETIVE STRATEGIES OF NOUN-NOUN COMBINATION

ABSTRACT

1. INTRODUCTION

METHOD

RESULTS

DISCUSSION

ACKNOWLEDGMENT

REFERENCES

Chapter 3 PROTEIN KINASE C ISOFORM ACTIVITY AND COGNITIVE FUNCTIONS

ABSTRACT

1. INTRODUCTION

2. PKC ISOZYMES

3. PKC ISOFORM ACTIVATION

4. SYNAPTIC AND NEURONAL FUNCTIONS

5. AXON REGENERATION AND SYNAPTOGENESIS

6. NEURONAL SURVIVAL

7. MEMORY AND ALZHEIMER’S DEMENTIA

8. ISCHEMIC DEMENTIA

CONCLUSION

REFERENCES

Chapter 4 BEHAVIOURAL AND COGNITIVE ABNORMALITIES IN 3XTG-AD MICE

ABSTRACT

1. INTRODUCTION

2. GENERATION AND PATHOPHYSIOLOGY OF THE 3XTG-AD MOUSE

3. COGNITIVE AND BEHAVIOURAL FEATURES OF THE 3XTG-AD MOUSE

CONCLUSION

REFERENCES

Chapter 5 RESOLVING THE P25 CONTROVERSY IN ALZHEIMER’S DISEASE

ABSTRACT

1. WHAT IS AD?

2. CDK5 AND ITS ACTIVATORS

3. CDK5-P25 IN AD

4. POST-MORTEM STUDIES ON P25 AND P35

5. MOUSE MODELS OF P25 OVEREXPRESSION

6. THE EARLY COMPENSATION HYPOTHESIS

7. DISCUSSION ON DISCREPANCIES IN THE LITERATURE

8. IMPLICATIONS OF A DOWNREGULATION OF P25 IN AD

ACKNOWLEDGMENTS

REFERENCES

Chapter 6 THE COGNITIVE NEUROSCIENCE OF AUTOMATICITY: BEHAVIORAL AND BRAIN SIGNATURES

ABSTRACT

1. INTRODUCTION

2. BEHAVIORAL SIGNATURES

3. PROCESS-BASED EXPLANATIONS OF AUTOMATICITY

4. THE NEUROSCIENCE OF AUTOMATICITY

CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Chapter 7 TRANSACTIVE RESPONSE DNA-BINDING PROTEIN-43 PATHOLOGY IN ALZHEIMER’S DISEASE: COMBINED DISEASE OR SHARED DEGENERATIVE PATHWAYS?

ABSTRACT

1. INTRODUCTION

2. TDP-43 AND NEURODEGENERATION

3. FREQUENCY AND DISTRIBUTION OF TDP-43 PATHOLOGY IN ALZHEIMER’S DISEASE

4. BIOCHEMICAL CHARACTERIZATION AND SUB CELLULAR LOCALIZATION OFTDP-43 AGGREGATES IN AD

5. PATHOLOGICAL CORRELATION

6. CLINICAL CORRELATION

7. DISCUSSION

REFERENCES

Chapter 8 MTOR IS A POTENTIAL THERAPEUTIC TARGET FOR ALZHEIMER’S DISEASE

ABSTRACT

1. INTRODUCTION

2. MTOR SIGNALING NETWORK

3. ALZHEIMER’S DISEASE

4. MTOR AND ALZHEIMER’S DISEASE: IS IT AN ADVANTAGEOUS PARTNERSHIP?

CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Chapter 9 EMOTION REGULATION NETWORKS AND NEUROFEEDBACK IN DEPRESSION

ABSTRACT

1. INTRODUCTION

2. A BRIEF HISTORY OF NEUROFEEDBACK IN DEPRESSION

3. BEHAVIOURAL AND THERAPEUTIC EFFECTS OF REAL TIME FMRI-FEEDBACK

4. APPLICATION TO DEPRESSION

5. NEURAL MECHANISMS AND PROSPECTIVE TARGETS IN DEPRESSION

6. EXTENDING MULTIVARIATE REALTIME-FMRI-FEEDBACK TO DEPRESSION

7. LIMITATIONS

8. FUTURE DIRECTIONS IN REAL TIME-FMRI-FEEDBACK

CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Chapter 10 PHENCYCLIDINE-INDUCED COGNITIVE IMPAIRMENT AND ITS NEURAL MECHANISMS

ABSTRACT

1. INTRODUCTION

2. PCP ADMINISTRATION IN THE ADULT PERIOD

3. PCP ADMINISTRATION DURING BRAIN DEVELOPMENT (PERINATAL ADMINISTRATION)

CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Chapter 11 MECHANISMS FOR NEUROPROTECTIVE EFFECTS OF ESTROGENS: THE ROLE OF CHOLESTEROL

ABSTRACT

1. INTRODUCTION

2. NEUROPROTECTIVE EFFECTS OF ESTROGENS

3. THE IDENTIFICATION OF SELADIN-1

4. SELADIN-1 AND CHOLESTEROL

5. CHOLESTEROL AND AD

6. ESTROGENS AND SELADIN-1

7. A WORKING HYPOTHESIS ON THE RELATIONSHIP BETWEEN CHOLESTEROL, ESTROGENS AND SELADIN-1 IN NEUROPROTECTION

ACKNOWLEDGMENTS

REFERENCES

Chapter 12 INAPPROPRIATE SEXUAL BEHAVIORS IN DEMENTIA: A REVIEW OF LITERATURE

ABSTRACT

1. INTRODUCTION

2. DEFINITION AND CLASSIFICATION

3. EPIDEMIOLOGY

4. BIOLOGICAL ASPECTS

5. ASSESSMENT

6. MANAGEMENT

CONFLICT OF INTEREST AND SOURCE OF FUNDING

REFERENCES

INDEX