Journey through the World of Malaria ( Allergies and Infectious Diseases )

Publication series :Allergies and Infectious Diseases

Author: Abubakar Yaro (Africa Health Research Organization   Cantonments   Accra Ghana)  

Publisher: Nova Science Publishers, Inc.‎

Publication year: 2014

E-ISBN: 9781631170652

P-ISBN(Paperback): 9781629486369

Subject: Q93 Microbiology

Keyword: Virology

Language: ENG

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Journey through the World of Malaria

Chapter

Chapter II: The Malaria Parasite and Its Life Cycle

Brief Insight into Plasmodium Genome

Metabolism: An Overview

Metabolomics in Malaria Research

Chapter III: Recent Advances in the Epidemiology of Human Malaria

Molecular Epidemiology

Introduction

Polymerase Chain Reaction

Use of Molecular Technique for Malaria Parasite Detection

Sub Patent Infection

Mixed Infection

Differentiate Recrudescence from Reinfection

Multiplicity Infection

Co-infection

Current Picture

Distribution

Mortality Pattern

Chapter IV: Pathogenesis and Clinical Features of Malaria Infection

Introduction

Malaria Parasite and Human Immune System

HLA System and Malaria

Immune Evasion in Malaria Infection

Biomarkers of Virulence

Clinical Manifestations

Human Cerebral Malaria

Placental Malaria

Severe Malarial Anemia (SMA)

Black Water Fever

Liver Dysfunction

Can Automated Red Blood Cell (RBC) Be Used for Treating Severe Plasmodium falciparum Malaria?

Malaria Diagnosis

Examples of RDT Available

Optimal-IT®

Paracheck-pf®

CareStart Malaria Tm (AccessBio Inc)

VIKIA Malaria Ag Pf/panTM

SD Malaria Antigen Malaria Pf 05FK90-02-0 (HRP2/PLDH)

Chapter V: Update in Malaria Treatment and Resistance

Pharmacological Properties of Antimalarial Drugs

Mechanisms of Action

Overview of Main Drug Classes

What Is Available Now?

Mode of Action

Clinical Pharmacokinetics

Formulation of ACT Available

Limitation of Artemisinins

Mechanism of Drug Resistance

Techniques in Identifying Resistance

Management of Drug Resistance

Stages of Drug Development

Preclinical Studies

Phase 1 Human Studies

Phase II Human Studies

Phase III Human Studies

Phase IV Human Studies

New Drugs and Novel Strategies in the Pipeline

Chapter VI: Malaria Control

Economic and Social Burden of Malaria

Can We Eradicate Malaria?

Global Warming and Malaria

Treating Asymptomatic Carriers

Intermittent Presumptive Treatment (IPT) in Pregnancy

Counterfeit Drugs

Affordable Medicine Facility

Malaria Funding

Insecticide Treated Net Beds (ITNS)

Novel Vector Control

Education

The T3: Test. Treat. Track

Human Factor

Controlling Imported Malaria

Malaria Vaccine

Vaccine Design

Vaccine Antigens

Pre-erythrocytic Antigen

Circumsporozoite protein (CS)

SSP

Liver Stage Antigen 1 (LSA1)

Merozoite and Erythrocytic Antigen

Erythrocyte Binding Antigen 175 (EBA-175)

Merozoite Surface Protein 1 (MSP 1)

MSP 2

Apical Membrane Antigen 1 (AMA1)

Serine Repeat Antigen (SERA)

Transmission-Blocking and Pathogenicity Antigen

Psf25

Cytoadherence Antigen

Malaria Vaccine in Clinical Trials

RTS, S Candidate

MSP3-LSP Candidate

MSP2-C1 Candidate

Conclusion: Future of Malaria

Further Reading

About this Book

About the Author

Index

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JOURNEY THROUGH THE WORLD OF MALARIA

JOURNEY THROUGH THE WORLD OF MALARIA

Library of Congress Cataloging-in-Publication Data

Contents

Preface

Acknowledgements

Chapter I: Introduction: History and Classification

Historical Perspective

Evolution of Malaria Parasite

Thalassemias

Glucose-6-Phosphate Deficiency

Sickle Cell Trait

Hemoglobin C

Hemoglobin E

Ovalocytosis

RBC Duffy Negativity

Where, When and How Did Malaria Evolved?

Chapter II: The Malaria Parasite and Its Life Cycle

Brief Insight into Plasmodium Genome

Metabolism: An Overview

Metabolomics in Malaria Research

Chapter III: Recent Advances in the Epidemiology of Human Malaria

Molecular Epidemiology

Introduction

Polymerase Chain Reaction

Use of Molecular Technique for Malaria Parasite Detection

Sub Patent Infection

Mixed Infection

Differentiate Recrudescence from Reinfection

Multiplicity Infection

Co-infection

Current Picture

Distribution

Mortality Pattern

Chapter IV: Pathogenesis and Clinical Features of Malaria Infection

Introduction

Malaria Parasite and Human Immune System

HLA System and Malaria

Immune Evasion in Malaria Infection

Biomarkers of Virulence

Clinical Manifestations

Human Cerebral Malaria

Placental Malaria

Severe Malarial Anemia (SMA)

Black Water Fever

Liver Dysfunction

Can Automated Red Blood Cell (RBC) Be Used for Treating Severe Plasmodium falciparum Malaria?

Malaria Diagnosis

Examples of RDT Available

Optimal-IT®

Paracheck-pf®

CareStart Malaria Tm (AccessBio Inc)

VIKIA Malaria Ag Pf/panTM

SD Malaria Antigen Malaria Pf 05FK90-02-0 (HRP2/PLDH)

Chapter V: Update in Malaria Treatment and Resistance

Pharmacological Properties of Antimalarial Drugs

Mechanisms of Action

Overview of Main Drug Classes

What Is Available Now?

Mode of Action

Clinical Pharmacokinetics

Formulation of ACT Available

Limitation of Artemisinins

Mechanism of Drug Resistance

Techniques in Identifying Resistance

Management of Drug Resistance

Stages of Drug Development

Preclinical Studies

Phase 1 Human Studies

Phase II Human Studies

Phase III Human Studies

Phase IV Human Studies

New Drugs and Novel Strategies in the Pipeline

Chapter VI: Malaria Control

Economic and Social Burden of Malaria

Can We Eradicate Malaria?

Global Warming and Malaria

Treating Asymptomatic Carriers

Intermittent Presumptive Treatment (IPT) in Pregnancy

Counterfeit Drugs

Affordable Medicine Facility

Malaria Funding

Insecticide Treated Net Beds (ITNS)

Novel Vector Control

Education

The T3: Test. Treat. Track

Human Factor

Controlling Imported Malaria

Malaria Vaccine

Vaccine Design

Vaccine Antigens

Pre-erythrocytic Antigen

Circumsporozoite protein (CS)

SSP

Liver Stage Antigen 1 (LSA1)

Merozoite and Erythrocytic Antigen

Erythrocyte Binding Antigen 175 (EBA-175)

Merozoite Surface Protein 1 (MSP 1)

MSP 2

Apical Membrane Antigen 1 (AMA1)

Serine Repeat Antigen (SERA)

Transmission-Blocking and Pathogenicity Antigen

Psf25

Cytoadherence Antigen

Malaria Vaccine in Clinical Trials

RTS, S Candidate

MSP3-LSP Candidate

MSP2-C1 Candidate

Conclusion: Future of Malaria

Further Reading

About this Book

About the Author

Index

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