Front Cover

Clinical Neuroendocrinology

Copyright Page

Table of Contents

Contributors

List of Contributors

Preface

Contents of Volume I

Chapter 1. Gonadal Hormones and Sexual Behavior

I. INTRODUCTION

II. NORMAL PHYSIOLOGY OF GONADAL STEROIDS

III. PHASES OF SEXUAL LIFE

IV. NORMAL SEXUAL DIFFERENTIATION

V. EFFECT OF HORMONES ON THE SEXUAL BEHAVIOR OF ANIMALS

VI. CONTROL OF LIBIDO AND POTENTIA

VII. SEXUAL IDENTIFICATION IN THE HUMAN

VIII. MANAGEMENT OF PATIENTS WITH AMBIGUOUS GENITALIA

IX. CONCLUSION

REFERENCES

Chapter 2. The Hypothalamic–Pituitary Unit: The Maturation of the Neuroendocrine System in the Fetus

I. INTRODUCTION

II. THE DEVELOPMENT OF THE HYPOTHALAMIC-PITUITARY UNIT

III. THE REGULATION OF ADENOHYPOPHYSEAL FUNCTION IN THE FETUS AND NEONATE

IV. CONCLUDING COMMENTS

ACKNOWLEDGMENTS

REFERENCES

Chapter 3. Neurotransmitter Control of Anterior Pituitary Hormone Secretion and Its Clinical Implications in Man

I. INTRODUCTION

II. ROLE OF CATECHOLAMINERGIC NEUROTRANSMITTERS

III. ROLE OF SEROTONIN (5-HT)

IV. ROLE OF ACETYLCHOLINE

V. ROLE OF HISTAMINE AND y-AMINOBUTYRIC ACID (GABA)

VI. ROLE OF OPIOID PEPTIDES

VII. CLINICAL SIGNIFICANCE OF NEUROPHARMACOLOGICAL MEDIATION OF HYPOTHALAMIC-PITUITARY RELATIONSHIPS

REFERENCES

Chapter 4. Neuroendocrine Correlates of the Endorphins and Enkephalins

I. INTRODUCTION

II. ISOLATION AND IDENTIFICATION OF THE ENKEPHALINS AND ENDORPHINS

III. MEASUREMENT OF THE ENKEPHALINS AND ENDORPHINS

IV. DISTRIBUTION OF OPIATE RECEPTORS AND ENDOGENOUS OPIATE PEPTIDES

V. RECENT CONCEPTS

VI. POSSIBLE PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ROLES OF ENDOGENOUS OPIATE PEPTIDES

VII. CONCLUSION—FUTURE OUTLOOK

ACKNOWLEDGMENTS

REFERENCES

Chapter 5. Studies on Melatonin and Other Pineal Factors

I. INTRODUCTION

II. PINEAL-BRAIN INTERACTION

III. HUMAN PATHOLOGY

IV. FUTURE TRENDS IN PINEAL RESEARCH

REFERENCES

Chapter 6. Endocrine Changes in Psychiatric Illness

I. INTRODUCTION

II. DEPRESSION

III. HYPOMANIA AND MANIA

IV. SCHIZOPHRENIA

V. ANOREXIA NERVOSA

REFERENCES

Chapter 7. Clinical Context, Neuroendocrine Relationships, and Nature of Inhibin in Males and Females

I. HISTORY

II. DEMONSTRATIONS OF THE EXISTENCE OF INHIBIN

III. NATURE OF INHIBIN

IV. PHYSIOLOGY OF INHIBIN

V. THE MODERN INHIBIN HYPOTHESIS

ACKNOWLEDGMENTS

REFERENCES

Chapter 8. Gut Hormones and the Brain

I. HISTORICAL NOTES

II. CONCEPTS

III. METHODS

IV. NOMENCLATURE

V. MOLECULAR HETEROGENEITY

VI. THE PEPTIDES

VII. THE BRAIN-VISCERAL AXIS

VIII. SUMMARY AND CONCLUSIONS

REFERENCES

Chapter 9. Somatostatin and Its Physiology in Man in Health and Disease

I. INTRODUCTION

II. ISOLATION, STRUCTURE, AND SYNTHESIS OF SOMATOSTATIN

III. ACTIONS OF EXOGENOUSLY ADMINISTERED SOMATOSTATIN

IV. MECHANISM OF ACTION OF SOMATOSTATIN

V. MEASUREMENT OF SOMATOSTATIN

VI. METABOLISM OF SOMATOSTATIN

VII. ANATOMICAL LOCALIZATION OF SOMATOSTATIN

VIII. MOLECULAR HETEROGENEITY OF SOMATOSTATIN

IX. THE PHYSIOLOGICAL ROLE OF SOMATOSTATIN

X. PATHOLOGY OF SOMATOSTATIN

XI. CONCLUSIONS

REFERENCES

Chapter 10. Interspecies Study on the Distribution of Peptide Hormones Secreted by Neurons

I. INTRODUCTION

II. HORMONES OF THE HYPOTHALAMIC-NEUROHYPOPHYSEAL SYSTEM

III. LUTEINIZING HORMONE-RELEASING HORMONE

IV. SOMATOSTATIN

V. THYROTROPIN-RELEASING HORMONE

VI. SUMMARY AND CONCLUSION

ACKNOWLEDGMENTS

REFERENCES

Index