Chapter
Mapping of the Ganglioside GM1 Distribution in the Basal Ganglia
Effects of GM1 and FGF-2 on Basal Ganglia Trophism
General Comments and Conclusions
Chapter 2. DARPP-32 / Protein Phosphatase-1 /Na+/K+ATPase System: A Mechanism for Bidirectional Control of Cell Function
Phosphorylation and Dephosphorylation of DARPP-32 In Vitro
Effect of Glutamate on DARPP-32 Phosphorylation
Dopamine Inhibition of Na+/K+ ATPase in Brain and Kidney
Effect of Phospho-DARPP-32 Peptide in Kidney Tubules onNa+/K+ ATPase Activity
Stimulation of Na+/K+ATPase Activity by Norepinephrine
Phosphorylation and Dephosphorylation of Na+/K+ ATPase In vitro
Summary — A General Mechanism for Bidirectional Control of CellFunction
Chapter 3. Muscle-Derived Differentiation Factorand its Regulation of the Tyrosine Hydroxylase Gene inthe Developing, Adult and Lesioned Rat Brain
MDF: Studies in Tissue Culture
Chapter 4. Glucocorticoid and Estrogen Effects on the Nigrostriatal and Mesolimbic Dopaminergic Systems
Regulation of Neuropeptide Gene Expression by Dopamine and by Adrenal Steroids
Glucocorticoid and Mineralocorticoid Receptor Distribution
Glucocorticoid and Enkephalin Effects on Exploratory Activity and Stereotyped Behavior
Estrogen Effects on Basal Ganglia
Rapid Effects of Estradiol and Progesterone on Basal Ganglia
Delayed Effects of Estradiol on the Basal Ganglia
Other Explanations for Estradiol Actions
Chapter 5. Factors Associated to Dopaminergic Cell Deathin Parkinson's Disease
Neurochemical Abnormalities in the Substantia Nigra in Parkinson's Disease: A Role of Hyperoxydation Phenomena in Neuronal Death ?
Neurochemical Abnormalities in the Dopaminergic Nigrostriatal Neurons in Parkinson's Disease: Deficits in the Machinery Leading to Dopamine Formation
Chapter 6. Compensatory Mechanisms At Dopamine D-2 Receptors
Heterogeneity of D-2 Receptors
Allosteric Multiprotein Receptor Structure and Signal Processing
Chapter 7. Oxidative Stress and Reduced Receptor Responsiveness in Senescence
Chapter 8. Expression, Regulation and Receptor Distribution of Neurotrophins in the Mammalian Central Nervous System
Chapter 9. Localization of Neurotrophins and Their Receptors at the mRNA and Protein Level
Cellular Localization of Neurotrophin mRNA
Localization of Neurotrophin Receptor mRNA Species
Development of neurotrophin-specific antibodies
A cell line that expresses proBDNF and BDNF
Cellular localization of BDNF in the brain
BDNF mRNA and protein in the perturbed brain
Neurotrophin Expression is Decreased in Alzheimer's Disease
Chapter 10. Effects of Brain-Derived Neurotrophic Factoron Injured Dopaminergic Neurons
BDNF Reduces Susceptibility of Dopaminergic Neurons in Culture to MPP+
Intraventricular BDNF Treatment Fails to Protect Dopaminergic Neurons in the Adult Rat Brain from Degeneration Following Axotomy
Chapter 11. Fibroblast Growth Factors and Parkinson's Disease
FGF-2 Protects MPTP-Lesioned Nigrostriatal Neurons In Vivo
FGF-2 Protects MPTP- and MPP+-Lesioned Nigrostriatal Dopaminergic Neurons In Vitro
Is FGF-2 a Retrogradely Acting Neurotrophic Factor in the Nigrostriatal System?
Chapter 12. Homeobox Peptides as a Novel Class of Neurotrophic Molecules
Chapter 13. Growth Factors Involved in the Development, Maturation and Neuroplasticity of Midbrain Dopamine Neurons
Multiple Dopaminergic Phenotypes
Chapter 14. Ganglioside and Growth Factor Interactions Promote Mesencephalic Cell Survival from the Excitotoxic Actions of 2,4,5- Trihydroxyphenylalanine
Topa-Induced Neurotoxicity is Mediated Via Activation of Non-NMDA Glutamate Receptors
GM1 and bFGF Reduce TOPA Neurotoxicity to Mesencephalic Neurons
Chapter 15. Trophic Factors and GM1 Ganglioside in theBasal Ganglia
Chapter 16. The Role of Gangliosides and Trophic Factors in Brain Repair
Biochemistry of Endogenous and Exogenous Gangliosides
Effects of Treatment with Exogenous Gangliosides
Influence on Biosynthetic Processes (Biochemical Recovery)
Interaction with Trophic Factors
Effects of Ganglioside Treatment on Morphological Recovery
Effects of Gangliosides on Behavioral Recovery
Chapter 17. Features of the Trophic Action of Polya mines
Features of Polyamine Metabolism After Neurotrauma
The central nervous system (CNS)
Putative Polyamine Functions in Cellular Defense Mechanisms
Pharmacology of Polyamines
Chapter 18. Acidic and Basic Fibroblast Growth Factorsare Present in, and Produce Effects upon, Mesencephalic Dopamine Neurons
Chapter 19. Presence of lnterleukin-1 in the Central Nervous System
Presence of IL-1 in Neural Elements
IL-1 Expression in Non-Neuronal Brain Elements
Chapter 20. Cellular Immediate-Early Genes in the Nervous System: Genes for All Reasons?
Characteristics of the cIE Gene Class
Classification of cIE Genes
Expression of cIE Genes in the CNS
Role of cIE Genes in the CNS: Learning and Memory
Development and Regeneration
Chapter 21. Neuropeptide Synthesis in Astrocytes: PossibleTrophic Roles
Chapter 22. Beta-Amyloid Precursor: A Neuronal and Glial-Derived Protein With Trophic-like Activities
Multifunctional APPs: Many Protein Isoforms and Functional Domains
Multifunctional APPs: Multiple Intracellular Routes of Trafficking
Functions of APP Defined In Vitro Relevant to Brain Injury
Expression of APP In Brain
APP In Reactive Astroglia Following Neuronal Injury
Possible Trophic-like Functions of Glial-Derived APP
Chapter 23. Neuron-Glia Interactions: Receptor Induced Events in Single Astroglial Cells and Their Implications for Neuronal Excitability and For Neurotransmission
One Model System for the Study of Astrocytes
Communication Between Different Astroglial Receptors at the Level of the Second Messenger
Astroglial Receptor Regulation of Uptake Carriers for Glutamate andGABA
Stimulation of Astroglial Receptors—Hypothetical Roles for theControl of Neuronal Excitability
Astroglial Signaling within the Astroglial Syncytium
Chapter 24. Astrocytic Kynurenines as Modulators of Dopaminergic Function in the Rat Basal Ganglia
Chapter 25. Neurochemical and Behavioral Studies on L-dopa Toxicity in the Model of Manganese Lesioned Nigrostriatal Pathway in the Rat: Evidence for a Protective Effect of the GM1 Lactone Siagoside
Does L-Dopa Administration Worsen Nigral Cell Damage?
Protective Effects of Gangliosides on L-Dopa-Induced Worsening of Nigrostriatal Degeneration
Final Comment: A Possible Role of Gangliosides in Preventing Long-Term Side Effects of L-dopa Therapy
Chapter 26. The MPTP Model of Parkinson's Disease in the Mouse. Modafinil—a New Potential Neuroprotective Agent
Chapter 27. Recovery from MPTP-induced Parkinsonism in Monkeys and Cats: Similar Mechanisms?
Chapter 28. The Evaluation of Antiparkinsonian Activities in Primate Models of Parkinsonism
Monkeys with Unilateral VMT Lesions of the Brain Stem
Monkeys with MPTP Induced Bilateral and Unilateral Parkinsonism
Chapter 29. The 3-Acetylpyridine Model of Parkinsonism: Use of Cytochrome Oxidase Gene Expression asan Index of Alterations in Basal Ganglia Function
Effects of 3-AP on the Striatal DA Innervation
Effects of 3-AP on Midbrain DA Neurons—Clues to the Temporal Course of Degeneration
Comparison of 3-AP- and MPTP-induced Parkinsonism
Advantages of 3-AP-Induced Neurotoxicity as an Animal Model of Parkinsonism
3-AP-Induced Changes in Mitochondrial Cytochrome Oxidase Gene Expression
Chapter 30. Neuronal Plasticity: A Potential Role in Spiny Striatal Neuron Degeneration in Huntington's Disease
Chapter 31. Plasticity Responses After Neonatal Dopamine Lesions Induced With 6-Hydroxydopamine
Neonatal DA Lesions with 6-Hydroxydopamine
Changes in DA Innervation after Neonatal 6-OHDA Lesions
Compensatory Activity in Remaining DA Circuits
Changes in Other Transmitter Systems of the Basal Ganglia
Chapter 32. Compensatory Neurobiological Changes after Partial Lesions with 6-Hydroxydopamine
6-Hydroxydopamine-Treated Rats
Why Do Lesions Produce So Few Functional Deficits?
Hyperactivity of Residual DA Neurons: Its Neurobiological Basis
Is Dopaminergic Hyperactivity Compensatory?
Chapter 33. Responses of NeostriataI Dopaminoceptive Cells to the Ischemic Insult
Chapter 34. Morphological and Functional Adaptation of Basal Ganglia Neurons after Cerebral Ischemia
Chapter 35. Clearance and Diffusion of Locally Applied Dopamine in Normal and 6-Hydroxydopamine-Lesioned Rat Striatum
Chapter 36. Target-Specific Outgrowth from Grafted Dopaminergic Neurons
Chapter 37. The Pharmacotherapy of Parkinson's Disease: Current Status and Future Opportunities
Chapter 38. Signal Transduction Mechanisms on Striatal Dopaminergic Neurons: Importance in Neurotrophism and Neuropathology
Glutamate and GABA Receptors in Substantia Nigra DA Neurons
IEG Induction: a Component of Brain Plasticity Responses
The RADA Action of Gangliosides: A Mechanism that Selectively Antagonizes the Glutamate Excitotoxicity While Sparing Glutamate Channel Gating
Trophic Regulation of the Basal Ganglia
：Focus on Dopamine Neurons
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