Transfer Factor :Basic Properties and Clinical Applications

Publication subTitle :Basic Properties and Clinical Applications

Author: Ascher   Michael S.;Gottlieb   A. Arthur;Kirkpatrick   Charles H.  

Publisher: Elsevier Science‎

Publication year: 2014

E-ISBN: 9781483216157

P-ISBN(Paperback): 9780120646500

P-ISBN(Hardback):  9780120646500

Subject: R392 medical immunology

Language: ENG

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Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Description

Transfer Factor: Basic Properties and Clinical Applications covers papers about transfer factor.
The book presents papers on the in vitro studies of transfer factor; the characterization of transfer factor; and the animal models of transfer factor. The text also includes articles on the use of transfer factor in infectious and neoplastic diseases and transfer factor therapy.
Examples of papers on transfer factor therapy include the role of transfer factor in the treatment of lymphoma cutis in Wiskott-Aldrich syndrome, transfer factor immunotherapy of rheumatoid arthritis, and transfer factor therapy in a patient with an isolated T-cell deficiency. Immunologists, pathologists, oncologists, microbiologists and people involved in the study of infectious diseases will find the book invaluable.

Chapter

Concluding Remarks

References

DISCUSSION

CHAPTER 3. IN VITRO COMPARISON OF TF OBTAINED FROM SKIN TEST POSITIVE AND NEGATIVE INDIVIDUALS

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

DISCUSSION

CHAPTER 4. TRANSFER FACTOR: IN VITRO EFFECTS ON LYMPHOCYTE TRANSFORMATION

RESULTS

DISCUSSION

REFERENCES

DISCUSSION

CHAPTER 5. AUGMENTATION OF LYMPHOCYTE TRANSFORMATION BY DIALYSABLE TRANSFER FACTOR

Summary and introduction

Methodology and design

Discussion and conclusions

Acknowledgements

References

DISCUSSION

CHAPTER 6. LEUCOCYTE DIALYSATES REQUIRE PRECOMMITTED, ANTIGEN-REACTIVE CELLS TO AUGMENT LYMPHOCYTE PROLIFERATION

MATERIALS AND METHODS

RESULTS

CONCLUSIONS

DISCUSSION

REFERENCES

ACKNOWLEDGEMENT

DISCUSSION

CHAPTER 7. EXPERIMENTAL STUDIES OF TRANSFER FACTOR

1. IN VITRO STUDIES OF TF IN MAN

2. IN VITRO STUDIES OF LEUKOCYTE EXTRACTS IN THE MOUSE

REFERENCES

DISCUSSION

CHAPTER 8. SPECIFIC AND NONSPECIFIC EFFECTS OF TRANSFER FACTOR - DIALYZABLE LEUKOCYTE EXTRACTS

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

SUMMARY

ACKNOWLEDGMENTS

CHAPTER 9. IN VITRO CHARACTERIZATION OF THE TARGET CELL FOR TRANSFER FACTOR - DIALYZABLE LEUKOCYTE EXTRACTS

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

SUMMARY

ACKNOWLEDGMENTS

REFERENCES

DISCUSSION

SECTION II: IN VITRO STUDIES OF TRANSFER FACTOR – Il

CHAPTER 10. ACQUISITION OF MIXED CELL MIGRATION REACTIVITY BY ACTIVELY SENSITISED AND TRANSFER-FACTOR TREATED RHESUS MONKEYS

Summary and introduction

Methodology and design

Discussion and conclusions

Acknowledgements

References

DISCUSSION

CHAPTER 11. IN VITRO ASSAY FOR TRANSFER FACTOR USING DIRECT MIGRATION INHIBITION

References

DISCUSSION

CHAPTER 12. IN VITRO ASSAY FOR TRANSFER FACTOR BY MEANS OF LEUKOCYTE MIGRATION TEST (LMT)

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

ACKNOWLEDGMENTS

REFERENCES

DISCUSSION

CHAPTER 13. POTENTIATING EFFECT OF TRANSFER FACTOR UPON MACROPHAGE MIGRATION INHIBITION IN VITRO

Summary and introduction

Methodology and design

Discussion and conclusions

Acknowledgements

References

DISCUSSION

CHAPTER 14. EFFECTS OF DIALYZABLE TRANSFER FRACTOR ON ACCUMULATION OF CYCLIC NUCLEOTIDES BY LEUKOCYTES

INTRODUCTION

METHODS

RESULTS

DISCUSSION

ACKNOWLEDGEMENT

REFERENCES

DISCUSSION

CHAPTER 15. STUDIES WITH IN VITRO PRODUCED TRANSFER FACTOR

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

DISCUSSION

CHAPTER 16. Guinea Pig "Transfer Factor" In Vitro: Physico-chemical Properties and Partial Purification

MATERIALS AND METHODS

RESULTS AND DISCUSSION

REFERENCES

DISCUSSION

CHAPTER 17. In Vitro Transfer of Coccidioidin and Histoplasmin Sensitivity to "Nonsensitive" Leucocytes Utilizing Whole Cell Lysates from Skin Test Positive Coccidioidin Sensitive Humans: Evidence of Cross Reactivity in a Transfer System

Introduction

Materials and Methods-Skin Testing of Human Donors

Results

DISCUSSION

DISCUSSION

CHAPTER 18. PRODUCTION OF SHEEP ERYTHROCYTE ROSETTE FORMING CELLS BY LYMPHOCYTES CULTURED WITH LEUCOCYTE DIALYSATES

INTRODUCTION

METHODS

RESULTS

DISCUSSION

ACKNOWLEDGEMENT

REFERENCES

DISCUSSION

SECTION III: CHARACTERIZATION OF TRANSFER FACTOR

CHAPTER 19. IDENTIFICATION OF HYPOXANTHINE AS THE MAJOR COMPONENT OF CHROMATOGRAPHICALLY PREPARED TRANSFER FACTOR

MATERIALS AND METHODS

RESULTS

DISCUSSION

ACKNOWLEDGEMENTS

REFERENCES

DISCUSSION

CHAPTER 20. TRANSFER FACTOR - SOME BIOCHEMICAL OBSERVATIONS

CHAPTER 21. LOCAL TRANSFER OF DELAYED HYPERSENSITIVITY TO DOGS BY HUMAN TRANSFER FACTOR

DISCUSSION

CHAPTER 22. QUANTITATION OF TRANSFER FACTOR

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

ACKNOWLEDGMENTS

REFERENCES

DISCUSSION

CHAPTER 23. SOME PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES OF A TRANSFER FACTOR PREPARATION AND ITS CLINICAL APPLICATION

Preparation of TFZ

Characteristics of TFz donors

Physico-chemical properties

Pyroqenicity

Cytotoxicity

Other characteristics

Therapeutical trials

Side effects

Concluding remarks

DISCUSSION

REFERENCES

DISCUSSION

CHAPTER 24. ARJA UOTILA, KAI KROHN AND JUHANI VÄISÄNEN

DISCUSSION

CHAPTER 25. CHROMATOGRAPHY OF TRANSFER FACTOR AND ASSAY OF FRACTIONS IN VITRO

Introduction

Methods

Results

Discussion

REFERENCES

DISCUSSION

CHAPTER 26. Fractionation of Rhesus Monkey Dialyzable KLH- Transfer Factor and the in vitro Assay of Specific Biologic Activity Using the Indirect MIF Assay

Sephadex Chromatography

Preparation of Supernatant Fluids from Lymphocytesb Incubated with TFd and KLH

G-25 Sephadex Chromatography and Characterization of TFd

The Effect on PEC Migration of Supernatant Fluids Derived From KLH Negative Leucocytes Incubated With TFd and KLH

Discussion

DISCUSSION

CHAPTER 27. BOVINE TRANSFER FACTOR: ISOLATION AND CHARACTERISTICS

DISCLAIMER STATEMENT

REFERENCES

DISCUSSION

CHAPTER 28. BIOLOGICAL ACTIVITY OF SUBFRACTION OF HUMAN TRANSFER FACTOR

RESULTS

DISCUSSION

REFERENCES

DISCUSSION

CHAPTER 29. FRACTIONATION OF TRANSFER FACTOR WITH HIGH PRESSURE LIQUID CHROMATOGRAPHY AND E-ROSETTE ENHANCING ACTIVITY OF VARIOUS FRACTIONS

High Pressure Liquid Chromatography

E-rosettes

Thin Layer Chromatography

Amino Acid Analysis

DISCUSSION

ACKNOWLEDGEMENT

REFERENCES

DISCUSSION

SUPPLEMENTAL GENERAL DISCUSSION

SUPPLEMENTAL GENERAL DISCUSSION

SECTION IV: ANIMAL MODELS OF TRANSFER FACTOR

CHAPTER 30. CANINE TRANSFER FACTOR

MATERIALS AND METHODS

RESULTS

DISCUSSION

ACKNOWLEDGMENTS

REFERENCES

DISCUSSION

CHAPTER 31. "NON-SPECIFIC" EFFECTS OF HUMAN DIALYZABLE TRANSFER FACTOR

DISCUSSION

CHAPTER 32. TRANSFER OF CELLULAR REACTIVITY TO 3 NONHUMAN PRIMATE SPECIES WITH HUMAN AND BABOON TRANSFER FACTOR

Materials and Methods

Discussion

Acknowledgements

References

DISCUSSION

CHAPTER 33. PREVENTION OF HERPES SIMPLEX VIRUS TYPE 1 FATAL DISSEMINATION IN PRIMATES WITH HUMAN TRANSFER FACTOR

Materials and Methods

Results

Discussion

Acknowledgements

References

CHAPTER 34. TRANSFER OF DELAYED HYPERSENSITIVITY TO MICE WITH HUMAN IMMUNE CELL EXTRACTS

Hypothesis

Summary

Acknowledgements

References

DISCUSSION

CHAPTER 35. Human Transfer Factor in Guinea Pigs: Further Studies

ACKNOWLEDGMENTS

REFERENCES

DISCUSSION

CHAPTER 36. HUMAN TRANSFER FACTOR IN GUINEA PIGS: PARTIAL PURIFICATION OF THE ACTIVE COMPONENT

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

ACKNOWLEDGEMENTS

REFERENCES

DISCUSSION

CHAPTER 37. HUMAN TRANSFER FACTOR: TRIALS WITH AN ASSAY IN GUINEA PIGS

DISCUSSION

REFERENCES

DISCUSSION

Correlation of in vivo and in vitro activity of guinea pig transfer factor

SECTION V: TRANSFER FACTOR IN INFECTIOUS DISEASES

CHAPTER 38. Transfer Factor Therapy of Chronic Aggressive Hepatitis

DISCUSSION

CHAPTER 39. Attempted Immunotherapy with Dialyzable Transfer Factor in Hepatitis B Carrier Chimpanzees: Induction of Delayed Hypersensitivity to Hepatitis B Surface Antigen (HBsAg)

MATERIALS AND METHODS

RESULTS

DISCUSSION

SUMMARY

ACKNOWLEDGMENTS

REFERENCES

CHAPTER 40. TRANSFER FACTOR TREATMENT OF VIRAL DISEASES IN MILWAUKEE

DISCUSSION

CHAPTER 41. PRELIMINARY RESULTS ON THE SAFETY AND EFFICACY OF TRANSFER FACTOR IN LEPROSY

REFERENCES

DISCUSSION

CHAPTER 42. CLINICAL AND IMMUNOLOGIC RESULTS OF TRANSFER FACTOR THERAPY IN COCCIDIOIDOMYCOSIS

INTRODUCTION

MATERIALS AND METHODS

RESULTS

References and Notes

DISCUSSION

CHAPTER 43. COMBINATION TRANSFER FACTOR-AMPHOTERICIN B THERAPY IN A CASE OF CHRONIC MUCOCUTANEOUS CANDIDIASIS: A CONTROLLED STUDY

CASE REPORT

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

DISCUSSION

CHAPTER 44. Immunological Reconstitution of Chronic Mucocutaneous Candidiasis with Transfer Factor and Fetal Thymic Tissue

Discussion

References

DISCUSSION

CHAPTER 45. TRANSFER FACTOR THERAPY OF DISSEMINATED HISTOPLASMOSIS

INTRODUCTION

METHODS AND MATERIALS

CASE REPORT

COMMENT

REFERENCES

DISCUSSION

CHAPTER 46. SUPPLEMENTAL GENERAL DISCUSSION

SUPPLEMENTAL GENERAL DISCUSSION

SECTION VI: TRANSFER FACTOR IN NEOPLASTIC DISEASES

CHAPTER 47. TRANSFER FACTOR IMMUNOTHERAPY IN CANCER

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

DISCUSSION

CHAPTER 48. An Unusual Metastatic Lesion in a Patient with Osteosarcoma Receving Tumor Specific Transfer Factor

DISCUSSION

CHAPTER 49. IMMUNOTHERAPY OF HUMAN NEOPLASMS WITH TRANSFER FACTOR

REFERENCES

DISCUSSION

CHAPTER 50. ADJUNCTIVE TRANSFER FACTOR IN OSTEOGENIC SARCOMA: I. CLINICAL IMPLICATIONS OF CHEMOTHERAPY AND IMMUNOTHERAPY

MATERIALS, METHODS AND RESULTS

REFERENCES

DISCUSSION

CHAPTER 51. Case Discussion: Undifferentiated Sarcoma

CHAPTER 52. ADJUNCTIVE TRANSFER FACTOR IN OSTEOGENIC SARCOMA: II. METHODOLOGY AND RESULTS OF THE IMMUNOLOGICAL STUDIES

DISCUSSION

REFERENCES

DISCUSSION

CHAPTER 53. TRANSFER FACTOR THERAPY IN DISSEMINATED NEOPLASMS

INTRODUCTION

METHODS

RESULTS

DISCUSSION

CONCLUSIONS

BIBLIOGRAPHY

DISCUSSION

CHAPTER 54. CLINICAL TRIALS WITH TRANSFER FACTOR

MATERIALS AND METHODS

CONCLUSION

ACKNOWLEDGEMENT

REFERENCES

DISCUSSION

SECTION VII: TRANSFER FACTOR THERAPY

CHAPTER 55. THE ROLE OF TRANSFER FACTOR IN THE TREATMENT OF LYMPHOMA CUTIS IN WISKOTT-ALDRICH SYNDROME

CASE REPORT

DISCUSSION

ACKNOWLEDGEMENT

REFERENCES

DISCUSSION

Acknowledgements

References

DISCUSSION

CHAPTER 56. The Effect of a Chromatographically Purified Transfer Factor Component on Juvenile Rheumatoid Arthritis

DISCUSSION

CHAPTER 57. TRANSFER FACTOR IMMUNOTHERAPY OF RHEUMATOID ARTHRITIS

References

DISCUSSION

CHAPTER 58. Transfer Factor Therapy in a Patient with an Isolated T-cell Deficiency

Case History

Immunological Studies: B-cell System

Discussion

References

DISCUSSION

CHAPTER 59. EFFECTS OF TRANSFER FACTOR IN WALDENSTROM'S MACROGLOBULINEMIA AND MULTIPLE MYELOMA

REFERENCES

DISCUSSION

DISCUSSION

CHAPTER 60. TRANSFER FACTOR TREATMENT OF PATIENTS WITH MULTIPLE SCLEROSIS

INTRODUCTION

RESULTS

DISCUSSION

Acknowledgement

REFERENCES

DISCUSSION

CHAPTER 61. TRANSFER OF PROTECTIVE IMMUNITY TO FRIEND LEUKEMIA VIRUS BY CELL FREE EXTRACTS OF IMMUNE LYMPHOID CELLS

General Experimental Procedures

Experimental Results

Discussion and Conclusions

Summary

Acknowledgements

References

DISCUSSION

CHAPTER 62. LEUKAPHERESIS OF CANCER PATIENTS FOR ADOPTIVE IMMUNOTHERAPY

A. IN VIVO PARAMETERS

B. IN VITRO PARAMETERS

DISCUSSION

REFERENCES

DISCUSSION

CHAPTER 63. TRANSFER FACTOR AND SKIN GRAFTS

DISCUSSION

CHAPTER 64. ON THE NATURE OF TRANSFER FACTOR

REFERENCES

CHAPTER 65. INVESTIGATIONS ON THE TRANSFER OF CELLULAR IMMUNITY IN ANIMAL MODEL SYSTEM BY THE TRANSFER FACTOR

CHAPTER 66. HUMAN "TRANSFER FACTOR" ACTIVITY IN GUINEA PIGS

SUMMARY

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

DISCUSSION

CHAPTER 67. Lymphocyte Antigen Sensitivity As A Requirement for a Blastogenic Response to Transfer Factor

CHAPTER 68. Leishmania enriettii Infections in Guinea Pigs and Transfer Factor Obtained from Convalescent yet Immune Animals

Methods and Materials

Results and Discussion

References

DISCUSSION

CHAPTER 69. CLINICAL EVALUATION OF THE EFFECTS OF TRANSFER FACTOR ON MULTIPLE SCLEROSIS

Introduction

Patient Selection and Procedure

Preparation of Transfer Factor

Case Descriptions Are Given in Table I

REFERENCES

DISCUSSION

SECTION VIII: KEYNOTE ADDRESS

CHAPTER 70. A BIOCHEMIST'S VIEW OF THE MEDIATORS OF CELLULAR IMMUNITY, WITH SPECIAL REFERENCE TO TRANSFER FACTOR

SUMMARY

REFERENCES

CHAPTER 71. SUMMATION

Biochemistry

In Vitro Assay Systems

In Vitro Production of TF

In Vitro Pitfalls

Newer Animal Models for TF Activity

Clinical Applications

Subject Index

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