Chapter
PROSPECTS; MICROSOMAL MEMBRANES - A MULTIPHASE SYSTEM,LIMITATIONS OF A MODEL
CHAPTER 2. INTERACTIONS BETWEEN CYTOCHROME P-450 AND NADPH CYTOCHROMEP-450 REDUCTASE IN THE MICROSOMAL MEMBRANE
Organizational Models of the Monooxygenase Enzymes
Chemical Modification Studies
Incorporation of Purified Cytochrome P-450 into the Microsomal Membrane
Effect of Temperature on Monooxygenase Reactions
Requirements of a Nonrigid Model
CHAPTER 3. A STUDY OF CYTOCHROME P-450 REDUCTION BY SODIUM DITHIONITE
CHAPTER 4. INVESTIGATION OF MICROSOMAL HYDROXYLATING SYSTEM AT SUB-ZERO TEMPERATURES
CHAPTER 5. ISOLATION OF MICROSOMAL ELECTRON TRANSPORT COMPONENTS AND RECONSTITUTION OF THE ELECTRON TRANSFER ACTIVITY ON LIPOSOMAL VESICLES
CHAPTER 6. DIFFERENCES IN SUBSTRATE AFFINITY AND CATALYTIC SPECIFICITY OF INDUCIBLE AND NON-INDUCIBLE FORMS OF CYTOCHROME P-450 IN RABBIT LIVER
CHAPTER 7. EFFECTS OF BUFFER COMPOSITION ON THE LOW-SPIN ESR SPECTRUM OF CYTOCHROME P-450
CHAPTER 8. KINETICS OF TIAMUTINR INTERACTION WITH CYTOCHROME P–450 FROM RABBIT LIVER
CHAPTER 9. DIFFERENT PHASES OF HYDROXYLASE INDUCTION IN LIVER MICROSOMES OF FEMALE MICE DURING INHALATION OF CYCLOHEXANE AND D,L-CAMPHOR
CHAPTER 10. PROTEIN-LIPID INTERACTIONS IN THE LIVER MICROSOMAL HYDROXYLASE SYSTEM
INTERACTIONS OF PURIFIED DELIPIDATED P-450 WITH PC
INTERACTIONS OF THE P-450-DEPENDENT HYDROXYLASE SYSTEM WITH PC AND NEUTRAL FATS
BINDING OF TRITON X-100 TO CYT0CHR0ME P-450
CHAPTER 11. FURTHER STUDIES OF THE FLUROXENE MEDIATED DESTRUCTION OF HEPATIC MICROSOMAL CYTOCHROMES P-450 IN VITRO
CHAPTER 12. PURIFICATION OF MEMBRANE-BOUND OXYGENASES: ISOLATION OF TWO ELECTROPHORETICALLY HOMOGENEOUS FORMS OF LIVER MICROSOMAL CYTOCHROME P-450
CHAPTER 13. MICROSOMAL HEMEPROTEINS P-450LM-2 AND P-450 LM-4:COMPARATIVE STRUCTURAL STUDIES
CHAPTER 14. HEPATIC MICROSOMAL ETHANOL OXIDIZING SYSTEM: ISOLATION AND RECONSTITUTION
CHAPTER 15. CHARACTERIZATION OF NADPH-CYTOCHROME c(P-450) REDUCTASE PURIFIED BY BIOSPECIFIC AFFINITY CHROMATOGRAPHY UTILIZING SPECTROPHOTOMETRIC AND ELECTRON PARAMAGNETIC RESONANCE TECHNIQUES
CHAPTER 16. RELATIONSHIP BETWEEN THE MEMBRANE LIPIDS AND SUBSTRATE-CYTOCHROME P-450 BINDING REACTION IN BOVINE ADRENO-CORTICAL MICROSOMES
CHAPTER 17. KINETIC AND SPECTRAL EVIDENCE FOR MULTIPLE SPECIES OF CYTOCHROME P-450 IN LIVER MICROSOMES
CHAPTER 18. DIFFERENCES IN THE INTERACTIONS OF R AND S WARFARIN WITH HEPATIC MICROSOMAL CYTOCHROME P-450
CHAPTER 19. MULTIPLE FORMS OF HOUSEFLY CYTOCHROME P-4501
CHAPTER 20. CATALYTIC HYDROXYLATION ACTIVITIES AND SOME OTHER PROPERTIES OF PARTIALLY PURIFIED RABBIT PULMONARY MICROSOMAL CYTOCHROME P-450
CHAPTER 21. HEPATIC MICROSOMAL AND SOLUBILIZED MIXED-FUNCTION OXIDASE SYSTEMS FROM THE LITTLE SKATE, Raja erznacea, A MARINE ELASMOBRANCH
CHAPTER 22. AMINIMIDE POLYMERS AS SUPPORTS FOR AFFINITY CHROMATOGRAPHY,UNDER LOW AND HIGH PRESSURE, OF MICROSOMAL ENZYMES
CHAPTER 23. SEX DIFFERENCES IN THE PATTERN OF CYTOCHROMES P-450 IN RAT LIVER MICROSOMES
CHAPTER 24. CHARACTERIZATION OF MULTIPLE FORMS OF HIGHLY PURIFIED CYTOCHROME P-450 FROM THE LIVER MICROSOMES OF RATS, MICE AND RABBITS
CHAPTER 25. THE MECHANISM OF CYTOCHROME P450 ACTION
THE STRUCTURE OF CYTOCHROME P450 AND ITS REACTIONS WITH SUBSTRATES
THE REDUCTION OF THE CYTOCHROME P450-SUBSTRATE COMPLEX
THE FORMATION OF THE ACTIVE OXYGEN COMPLEX
THE MONOOXYGENATION OF THE SUBSTRATE
UNCOUPLED MONOOXYGENATIONS
CHAPTER 26. OXYGEN REACTIONS OF THE P450 HEME PROTEIN
CHAPTER 27. THE PEROXIDASE NATURE OFCYTOCHROME P450
CHAPTER 28. CYTOCHROME P450 CATALYZED OXENE TRANSFER FROM VARIOUS DONORS
CHAPTER 29. ASSOCIATION ON TYPE I, TYPE II,AND REVERSE TYPE I DIFFERENCE SPECTRA WITH ABSOLUTE SPIN STATE OF CYTOCHROME P-450 IRON
CHAPTER 30. NMR RELAXATION TIME STUDIES OFSUBSTRATE INTERACTIONS WITH P450 AND OTHER HEMOPROTEINS
CHAPTER 31. THE INTERACTION OF POLYHALOGENATED METHANES WITH FERROUS CYTOCHROME P450
CHAPTER 32. SUBSTRATE-ELICITED DISSOCIATION OF THE ISOSAFROLE METABOLITE-CYTOCHROME P-450 COMPLEX AND THE CONSEQUENTIAL REACTIVATION OF MONOOXYGENATION
CHAPTER 33. THE INTERACTION OF HALOTHANE WITH LIVER MICROSOMAL CYTOCHROME P450
CHAPTER 34. THE FORMATION OF HYDROGEN PEROXIDE DURING HEPATIC MICROSOMAL ELECTRON TRANSPORT REACTIONS
CHAPTER 35. OXYGEN TRANSFER IN MICROSOMALOXIDATIVE DESULFURATION
CHAPTER 36. REDOX AND LIGAND DYNAMICS IN P450 cam-PUTIDAREDOXIN COMPLEXES
PUTIDAREDOXIN-P450 REDOX DYNAMICS
ROLE OF PD-P450 COMPLEX IN REDOX AND LIGAND DYNAMICS
OTHER P450 INTERMEDIATES INVOLVED IN HYDROXYLATION
CHAPTER 37. THE INHIBITION OF MIXED-FUNCTION OXIDATION REACTIONS BY AMPHETAMINES IN LIVER AND LUNG MICROSOMES
CHAPTER 38. THE PHYSIOLOGICAL IMPLICATIONS OF DRUG OXIDATIONS TO THE CELL
CHAPTER 39. NICOTINAMIDE NUCLEOTIDE SYSTEMS AND DRUG OXIDATION IN THE LIVER CELL
CHAPTER 40. THE ROLE OF REDUCING EQUIVALENTS GENERATED IN MITOCHONDRIA IN HEPATIC MIXED-FUNCTION OXIDATION1
CHAPTER 41. DESTRUCTION OF CYTOCHROME P-450 BY LINOLEIC ACID HYDROPEROXIDE
CHAPTER 42. STOICHIOMETRY OF OXYGEN UPTAKE, NADPH OXIDATION AND ETHYLMORPHINE N-DEMETHYLATION BY HEPATIC MICROSOMES
CHAPTER 43. STRUCTURAL AND FUNCTIONAL INTERACTION OF ROUGH ENDOPLASMIC RETICULUM (RER) AND MITOCHONDRIA DURING SYNTHESIS OF HEPATIC CYTOCHROME P450
CHAPTER 44. MECHANISM OF N-OXIDE FORMATION BY HEPATIC MIXED FUNCTION OXIDASES
CHAPTER 45. A PRELIMINARY COMPARATIVE STUDY ON THE INFLUENCE OF CYSTEAMINE AND METYRAPONE ON MIXED-FUNCTION OXYGENASE ACTIVITIES IN VARIOUSLY PRETREATED LIVER MICROSOMES FROM RATS AND MICE
CHAPTER 46. INHIBITION OF RAT LIVER MICROSOMAL DT DIAPHORASE BY BENZO (a) PYRENE METABOLITE (S)
CHAPTER 47. CHARACTERISTICS OF THE HEPATIC MONOOXYGENASE CATALYZING THE METABOLISM OF PROSTAGLANDIN Ai (PGAi) IN GUINEA PIGS AND RATS I EFFECTS OF INDUCERS
CHAPTER 48. STUDIES ON A CYTOCHROME P-450-DEPENDENT HYDROXYLASE SYSTEM ACTIVE ON STEROIDS IN Bacillus megaterium
CHAPTER 49. IMPACT OF DRUG MONOXYGENASES IN CLINICAL PHARMACOLOGY
I. INTER-INDIVIDUAL DIFFERENCES IN DRUG RESPONSE
II PLASMA CONCENTRATIONS OF DRUGS
CHAPTER 50. THE ROLE OF LIVER NUCLEI IN THE FORMATION OF DNA BINDING PRODUCTS FROM BENZO (a) PYRENE
CHAPTER 51. MECHANISM OF MICROSOMAL ACTIVATION OF BENZO[a] PYRENE TO DIOL-EPOXIDES:THE SEPARATION AND CHARACTERIZATION OF INTERMEDIATES AND PRODUCTS
CHAPTER 52. THE METABOLISM OF BENZO[a]PYRENE IN CELL CULTURES AND HOMOGENATES FROM DIFFRENT HUMAN FETAL TISSES
CHAPTER 53. ARYL HYDROCARBON HYDROXYLASE IN CULTURED HUMAN LYMPHOCYTES1
CHAPTER 54. ASSIGNMENT OF A HUMAN GENE FOR ARYL HYDROCARBON HYDROXYLASE EXPRESSION TO CHROMOSOME 2
CHAPTER 55. OXIDATIVE METABOLISM OF CARCINOGENS BY TROUT LIVER RESULTING IN PROTEIN BINDING AND MUTAGENICITY
CHAPTER 56. DRUG-DRUG INTERACTIONS VIA INHIBITION OF MICROSOMAL ENZYMES INVOLVED IN METABOLISM OF EPOXIDES PRODUCED BY MICROSOMAL MONOOXYGENASE
INACTIVATION OF MUTAGENS PRODUCED FROM BENZO(A)PYRENE BY EPOXIDE HYDRATASE
DRUG-DRUG INTERACTIONS VIA INHIBITION OF EPOXIDE HYDRATASE
CHAPTER 57. LEVELS OF GLUTATHIONE AND GLUTATHIONE-METABOLIZING ENZYMES IN RAT LUNG
CHAPTER 58. THE DISPOSITION OF BENZO(A) PYRENE IN ISOLATED PERFUSED RAT LUNG
CHAPTER 59. EPOXIDE HYDRATASE IN RAT LUNG
CHAPTER 60. MONOOXYGENASE CATALYZED ACTIVATION OF THIONO-SULFUR CONTAINING COMPOUNDS TO REACTIVE INTERMEDIATES
CHAPTER 61. STIMULATORY EFFECTS OF POLYCHLORINATED BIPHENYLS (PCB) ON CYTOCHROMES P-450 AND P-448 MEDIATED MICROSOMAL OXIDATIONS
CHAPTER 62. DEPRESSION OF HEPATIC CYTOCHROME P-450-DEPENDENT MONOOXYGENASE SYSTEMS WITH ADMINISTERED INTERFERON INDUCING AGENTS
CHAPTER 63. ALTERATIONS OF HEPATIC MICROSOMAL MIXED FUNCTION OXYGENASE DEPENDENT H2O2 FORMATION DUE TO "UNCOUPLING" AND INDUCTION AS DEMONSTRATED IN VIVO BY ELIMINATION KINETICS OF ETHANOL IN GUINEA PIG
CHAPTER 64. THE MICROSOMAL METABOLISM OF CARCINOGENIC AND/OR THERAPEUTIC HYDRAZINES
CHAPTER 65. ROLE OF HYDROXYLATED METABOLITES OF PHENYTOIN IN DOSE-DEPENDENCY
CHAPTER 66. SPECIES DIFFERENCES IN DRUG METABOLISM; IN VIVO PARAMETERS OF HEPATIC DRUG-METABOLISING ENZYME ACTIVITY IN THE BABOON
CHAPTER 67. EVIDENCE FOR BINDING OF LIDOCAINE TO TWO CATALYTICALLY DIFFERENT SITES OF LIVER MICROSOMAL CYTOCHROME P-450
CHAPTER 68. DIFFERENTIAL INFLUENCE OF PHYSIOLOGICAL, PHARMACOLOGICAL AND PATHOLOGICAL ALTERATIONSON HEPATIC AND EXTRAHEPATIC DRUG METABOLISM
CHAPTER 69. METABOLISM OF HEXOBARBITAL ENANTIOMERS AND INTERACTION WITH CYTOCHROME P-450 IN MALE AND FEMALE MICE AND RATS
CHAPTER 70. THE MECHANISM OF DEGRADATION OF ENDOGENOUS HEME AND CYTOCHROME P-450 BY HEME OXYGENASE
CHAPTER 71. INDUCTION OF CYTOCHROME P-448 BY3-METHYLCHOLANTHRENE IN THERAT DURING INHIBITION OF PROTEINSYNTHESIS IN VIVO
CHAPTER 72. STIMULATION OF LIVER GROWTH ANDMIXED-FUNCTION OXIDASE BY α-HEXACHLOROCYCLOHEXANE:SEPARATION OF INDUCTIVE PATHWAYS
CHAPTER 73. INDUCTION OF CYTOCHROME P-450 BY LONG-TERM INFUSION OF PHENOBARBITAL
CHAPTER 74. METABOLISM AND MUTAGENICITY OF 2-ACYLAMINOFLUORENES AND RELATED COMPOUNDS
CHAPTER 75. IN VIVO PARAMETERS OF DRUGMETABOLISM–DIFFERENCES IN SPECIFICITY TOWARDS INDUCING AGENTS
CHAPTER 76. STUDIES ON THE MECHANISM BY WHICH DISULFIRAM AND DIETHYLDITHIOCARBAMATE AFFECT DRUG METABOLISM
CHAPTER 77. ALTERATIONS IN THE ACTIVITIES OF DRUG METABOLIZING ENZYMES INRAT LIVER MICROSOMES BY DIETARY AND IN VITRO INCORPORATED CHOLESTEROL
CHAPTER 78. STEROID-16 α-HYDROXYLASE IN RAT LIVER: BIOCHEMICAL AND BIOLOGICAL PROPERTIES
CHAPTER 79. CORRELATION BETWEEN DRUG, LIPID AND CARBOHYDRATE METABOLISM IN THE RAT AFTER CHRONIC BETA- ADRENORECEPTOR ANTAGONIST TREATMENT
CHAPTER 80. CONVERSION OF TRICHLOROETHYLENE TO CARBON MONOXIDE BY MICROSOMAL CYTOCHROME P450
CHAPTER 81. STEREOSELECTIVE IN VITRO AROMATIC OXYGENATION OF CHIRAL1.4-BENZODIAZEPIN-2-ONES
CHAPTER 82. EFFECTS OF DISEASE STATES ON DRUG DISPOSITION IN MAN
CHAPTER 83. ISOLATION OF RAT LIVER EPOXIDE HYDRATASE: PROPERTIES AND SUBSTRATE SPECIFICITY OF THE PURE ENZYME
CHAPTER 84. REDUCTION OF A TERTIARY AMINE N-OXIDE AND AN ARENE OXIDE IN RELATION TO THE REDUCTION RATE OF CYTOCHROME P-450 IN RAT LIVER MICROSOMES
CHAPTER 85. MICROSOMAL OXIDATION OF ISOPROTERENOL AND IRREVERSIBLE PROTEIN BINDING OF METABOLITES
CHAPTER 86. BENZO (α) PYRENE METABOLISM BY MICROSOMES AND ISOLATED EPITHELIAL CELLS FROM RAT SMALL INTESTINE
CHAPTER 87. CHARACTERIZATION OF THE DRUG MONOOXYGENASE SYSTEM IN MOUSE SMALL INTESTINE
CHAPTER 88. FORMATION OF ALKYLATION AND CARBAMYLATION INTERMEDIATES AND CYTOCHROME P-450 CATALYZED MONOOXYGENATION OF THE 2-CHLOROETHYLNITROSOUREAS CCNU AND METHYL CCNU
CHAPTER 89. PROPOSED MECHANISM FOR THE REDUCTIVE GLYCOSIDIC CLEAVAGE OF DAUNOMYCIN (NSC 82151) AND ADRIAMYCIN (NSC 123127)
CHAPTER 90. COVALENT BINDING OF STYRENE OXIDE TO RAT LIVER MACROMOLECULES IN VIVO AND IN VITRO
CHAPTER 91. THE REGULATION OF HUMAN DRUG METABOLISM BY NUTRITIONAL FACTORS
CHAPTER 92. THE BAY-REGION THEORY:A QUANTUM MECHANICAL APPROACHTO AROMATIC HYDROCARBON-INDUCED CARCINOGENICITY
CHAPTER 93. THE ACTIVATION AND INDUCTION OF BIPHENYL HYDROXYLATION AND CHEMICAL CARCINOGENESIS
CHAPTER 94. INTEGRATED ELECTRON TRANSFER:IRON STATES AND REGULATION
CHAPTER 95. PURIFICATION OF LIVER MICROSOMAL CYTOCHROME P-450:HOPES AND PROMISES
CHAPTER 96. ACTIVE OXYGEN–
FACT OR FANCY