Chapter
POSSIBLE PATTERNS OF GENETIC ORGANIZATION OF THE 1 REGION
DISCUSSION FOLLOWING DONALD SHREFFLER
CHAPTER 2. THE GENETICS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN
MAN, HLA
THE HLA SUPERGENE AND THE 6TH CHROMOSOME
THE GENETICS OF THE D(MLC-s) LOCUS
HLA AND DISEASE ASSOCIATIONS
DISCUSSION FOLLOWING JON van ROOD
CHAPTER 3. MOLECULAR RELATIONSHIPS OF la ANTIGENS CONTROLLED BY THE SAME
AND BY DIFFERENT SUBREGIONS OF THE I REGION
CHAPTER 4. Br AND Wh, B CELL ANTIGENS IN GLUTEN SENSITIVE ENTEROPATHY
AND DERMATITIS HERPETIFORMIS
CHAPTER 5. RECENT STUDIES OF la LIKE ANTIGENS AND COMPLEMENT COMPONENTS
RELATING TO THE HUMAN HISTOCOMPATIBILITY SYSTEM
THE ROCKEFELLER UNIVERSITY AND
SLOAN KETTERING INSTITUTE
COMPLEMENT-MHC RELATIONSHIPS
CHAPTER 6.
NATURAL KILLER CELLS IN THE MOUSE
SPECIFICITY OF
NATURAL KILLER CELLS
AGE VARIATION OF NATURAL KILLER
CELL ACTIVITY
EFFECTOR CELL ANALYSIS OF NATURAL KILLER
CELLS
GENETIC ANALYSIS OF NATURAL KILLER CELL ACTIVITY
IN VIVO RELEVANCE OF
NATURAL KILLER CELLS
CHAPTER 7. EVIDENCE FOR THE ASSOCIATION OF SPECIFICITY la.3
WITH AN I-A REGION MOLECULE
GENERAL DISCUSSION - SESSION I:
GENETICS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
SESSION II: The Biology of Mixed Lymphocyte Interactions and Cell-mediated Cytotoxicity Reactions
CHAPTER 8. GENETIC AND CELLULAR ASPECTS OF MIXED LEUKOCYTE CULTURE AND
CELL MEDIATED LYMPHOLYSIS REACTIONS
GENETIC CONTROL OF MLC — THE MHC LD SYSTEM
GENETIC CONTROL OF CML — "LD-SD COLLABORATION
CELLULAR RECOGNITION OF MHC ANTIGENS
SECONDARY RESPONSES IN VITRO
PRIMED LD TYPING (PLT) TEST
RESTIMULATION OF CYTOXICITY
MODEL — AN ATTEMPT AT SYNTHESIS
IN VIVO LD-SD COLLABORATION
DISCUSSION FOLLOWING FRITZ BACH
CHAPTER 9. BIFUNCTIONAL HISTOCOMPATIBILITY-LINKED REGULATION OF CELL MEDIATED LYMPHOLYSIS TO MODIFIED AUTOLOGOUS CELL
SURFACE COMPONENTS
REQUIREMENT FOR H-2 HOMOLOGY OF MODIFIED TARGET CELLS WITH
MODIFIED STIMULATING CELLS AND/OR RESPONDING LYMPHOCYTES
SPECIFICITY OF CYTOTOXICITY AS A FUNCTION OF THE MODIFYING AGENT
EFFECTOR CELL SPECIFICITY: MODIFIED AUTOLOGOUS H-2
PRODUCTS VS HAPTEN
CONCLUSIONS AND SPECULATIONS
DISCUSSION FOLLOWING GENE SHEARER
CHAPTER 10.
THE ROLE OF la ANTIGENS IN MLC STIMULATION
CHAPTER 11. H-2 ASSOCIATED MLR DETERMINANTS: IMMUNOGENETICS OF THE LOC
1 AND THEIR PRODUCTS
MLR ASSAY IN RECOMBINANT SCREENING
THE INHIBITION OF MLR WITH ANTI-la SERA
CHAPTER 12. RESPONSES OF ALLOANTIGEN REACTIVE LYMPHOCYTES TO CONVENTIONAL
ANTIGENS
CHAPTER 13. EVIDENCE FOR SEVERAL CLOSELY LINKED GENES INVOLVED
IN GENERATION OF PROLIFERATION IN MLC.
EVIDENCE THAT TWO D-LOCUS HOMOZYGOUS TYPING
CELLS BELONG TO THE SAME DW SPECIFICITY GROUP.
EVIDENCE FOR DIFFERENCES IN D-LOCUS SPECIFICITY
BETWEEN TWO TYPING CELLS OF THE DW4 SPECIFICITY GROUP
CHAPTER 14.
SUPPRESSIVE INTERACTIONS BETWEEN DIFFERENT MLR LOCI
CHAPTER 15. DOES THE APPARENT H-2 COMPATIBILITY REQUIREMENT FOR VIRUS–SPECIFIC T CELL-MEDIATED CYTOLYSIS REFLECT T CELL SPECIFICITY FOR "ALTERED SELF" OR PHYSIOLOGICAL
INTERACTION MECHANISMS
GENERAL DISCUSSION - SESSION II:
THE BIOLOGY OF MIXED LYMPHOCYTE INTERACTIONS AND CELL-MEDIATED CYTOTOXICITY REACTIONS
SESSION III:
Immune Response (Ir) Gene Systems
CHAPTER 16. THE NATURE AND FUNCTION OF SPECIFIC H-LINKED
IMMUNE RESPONSE GENES AND IMMUNE SUPPRESSION GENES BARUJ BENACERRAF AND MARTIN DORF
THE ACTIVITIES OF COMPLEMENTING HISTOCOMPATIBILITY-LINKED
Ir GENES IN THE CONTROL OF IMMUNE RESPONSES TO SYNTHETIC ANTIGENS
CIS-TRANS EFFECTS IN THE COMPLEMENTING OF α AND β
GENES
GENETIC CONTROL OF SPECIFIC IMMUNE SUPPRESSION
STRAIN DIFFERENCES IN THE SUPPRESSION BY GT
OF THE PRIMARY RESPONSE TO GT-MBSA
DISCUSSION FOLLOWING BARUJ BENACERRAF
CHAPTER 17. FUNCTIONAL ANALYSIS OF la ANTIGENS
IN RELATION TO GENETIC CONTROL OF THE IMMUNE RESPONSE
la ANTIGEN EXPRESSION ON B CELL
SUBPOPULATIONS
la ANTIGEN EXPRESSION ON T CELL SUBPOPULATIONS
DISCUSSION FOLLOWING HUGH McDEVITT
CHAPTER 18.
H-2 LINKED IMMUNE RESPONSE GENES: MULTIPLICITY AND FUNCTIONAL COMPLEMENTATION
CHAPTER 19. H-3-LINKED UNRESPONSIVENESS TO EA-1 AND H-13
ANTIGENS
EVIDENCE FOR THE MAP POSITION OF IR-2
UNRESPONSIVENESS OF YBR MICE MADE TOLERANT
OF BALB CELLS
H-3-LINKED LOW RESPONSE TO H-13 ANTIGENS
CHAPTER 20. IMMUNE RESPONSES OF MICE AGAINST MODIFIED RANDOM POLYMERS
OF AMINO ACIDS, AND IMPLICATIONS IN GENE CONTROL
RESPONSE TO GL COPOLYMERS MODIFIED WITH VARIOUS AMINO ACIDS
CHAPTER 21. A POSSIBLE FUNCTION FOR PRODUCTS OF THE MAJOR HISTOCOMPATIBILITY
COMPLEX IN HUMORAL IMMUNITY
GENERAL DISCUSSION - SESSION III:
IMMUNE RESPONSE (Ir) GENE SYSTEMS
SESSION IV:
Genetic Control of Cell Interactions
CHAPTER 22. MACROPHAGE-T LYMPHOCYTE INTERACTION: THE CELLULAR BASIS
FOR GENETIC CONTROL OF ANTIGEN RECOGNITION
I. MACROPHAGE FUNCTION IN ANTIGEN SPECIFIC T CELL ACTIVATION
II. HOW DO
MACROPHAGES INTERACT WITH LYMPHOCYTES
III. IMMUNE RESPONSE GENE FUNCTION IN MACROPHAGE-T
LYMPHOCYTE INTERACTION
IV. GENETIC ANALYSIS OF DETERMINANTS MEDIATING MACROPHAGE
T-LYMPHOCYTE INTERACTION
V. ROLE OF MACROPHAGE-ASSOCIATED ANTIGEN IN THE
REGULATION OF GENETIC CONTROL OF THE IMMUNE RESPONSE
DISCUSSION FOLLOWING ALAN ROSENTHAL
CHAPTER 23. GENETIC CONTROL OF LYMPHOCYTE INTERACTIONS AND
DIFFERENTIATION
EVIDENCE FOR GENETIC RESTRICTIONS IN COOPERATIVE T-B CELL
INTERACTIONS
EVIDENCE FOR FUNCTIONAL INTERRELATIONSHIPS BETWEEN CI AND Ir
GENES
THE CONCEPTS OF "ADAPTIVE DIFFERENTIATION"
AND "HAPLOTYPE PREFERENCE"
DISCUSSION FOLLOWING DAVID KATZ
CHAPTER 24. STIMULATION OF ANTIBODY RESPONSES IN VITRO BY
ANTIGEN-BEARING SYNGENEIC AND ALLOGENEIC MACROPHAGES
ABILITY OF SYNGENEIC AND ALLOGENEIC MACROPHAGES TO
SUPPORT DEVELOPMENT OF PRIMARY ANTIBODY RESPONSES IN VITRO
ABILITY OF SYNGENEIC AND ALLOGENEIC MACROPHAGES TO SUPPORT DEVELOPMENT OF SECONDARY ANTIBODY
RESPONSES IN VITRO
CHAPTER 25. H-2 LINKED Ir GENE REGULATION OF DELAYED-TYPE
HYPERSENSITIVITY IN MICE
CHAPTER 26. DIFFERENTIAL EXPRESSION OF la ANTIGENS ON SUPPRESSOR T
CELLS, HELPER T CELLS AND B PRECURSOR CELLS
la ANTIGENS ON FUNCTIONAL LYMPHOCYTE
SUBPOPULATIONS
ARE la ANTIGENS SECRETED BY
ACTIVATED LYMPHOCYTES
CHAPTER 27. EFFECTIVE ALLOGENEIC T CELL-B CELL INTERACTION
IN CHIMERIC MICE
GENERAL DISCUSSION - SESSION IV:
GENETIC CONTROL OF CELL INTERACTIONS
SESSION V: Idiotypic Determinants on T Cell
Receptors
CHAPTER 28. T LYMPHOCYTE RECEPTOR ANALYSIS
BY ANTI - IDIOTYPIC STIMULATION
SENSITIZATION BY ANTI-IDIOTYPIC ANTIBODY
HELPER CELLS INDUCED BY ANTI-IDIOTYPIC ANTI
BODYBEAR IDIOTYPIC RECEPTOR MOLECULES
DISCUSSION FOLLOWING KLAUS RAJEWSKY
CHAPTER 29.
IDIOTYPIC RECEPTORS FOR ANTIGEN ON T LYMPHOCYTES
DEMONSTRATION OF ANTI-IDIOTYPIC ANTIBODIES REACTIVE WITH
BOTH T AND B RECEPTORS FOR THE SAME ANTIGENIC DETERMINANTS
VISUALIZATION: FREQUENCY-DETERMINATION AND PHYSICAL
ISOLATION OF IDIOTYPE POSITIVE T LYMPHOCYTES
A SPECULATIVE DISCUSSION OF THE FREQUENCY OF
IDIOTYPE-POSITIVE LYMPHOCYTES
PRESENCE OF IDIOTYPIC MOLECULES WITH ANTI-AG-B ACTIVITY
IN SERUM AND URINE OF NORMAL ADULT RATS
DEMONSTRATION OF CELLULAE ORIGIN OF NATURALLY PRODUCED,
IDIOTYPE-POSITIVE MOLECULES WITH REACTIVITY AGAINST Ag-B ANTIGENS
SPECULATIONS AS TO THE STRUCTURE OF
THE T CELL RECEPTOR FOR ANTIGEN
DISCUSSION FOLLOWING HANS WIGZELL
SESSION VI: Properties of Histocompatibility Gene Products Involved in Regulation of Immune Responses
CHAPTER 30. THE NATURE OF ANTIGEN SPECIFIC T CELL FACTORS INVOLVED IN
THE GENETIC REGULATION OF IMMUNE RESPONSES
SPECIFICITY OF T CELL FACTORS
ISOLATION AND PURIFICATION OF A T CELL FACTOR PRODUCED WITH
(T,G)-A--L
THE T CELL FACTOR SPECIFIC FOR (T,G)-Pro—L IS A PRODUCT OF
THE H-2 COMPLEX
EFFECT OF T CELL FACTORS ON THE SPLENIC LEVELS OF CYCLIC AMP IN MICE
DISCUSSION FOLLOWING EDNA MOZES
CHAPTER 31. CHARACTERIZATION OF THE ANTIGEN-SPECIFIC SUPPRESSIVE T CELL FACTOR WITH SPECIAL REFERENCE TO
THE EXPRESSION OF J REGION GENES
GENERAL FEATURES OF THE ANTIGEN-SPECIFIC
SUPPRESSIVE T CELL FACTOR
THE ANTIGEN-SPECIFIC SUPPRESSIVE T CELL FACTOR AS AN I
REGION GENE PRODUCT
REQUIREMENT FOR HISTOCOMPATIBILITY IN THE EFFECTIVE
SUPPRESSION BY THE T CELL FACTOR IN DIFFERENT MOUSE STRAINS
DISCUSSION FOLLOWING TOMIO TADA
CHAPTER 32.
HISTOCOMPATIBILITY GENE PRODUCTS AS MEDIATORS OF LYMPHOCYTE INTERACTIONS
GENETIC AND CELLULAR REQUIREMENTS FOR AEF PRODUCTION
BIOLOGICAL PROPERTIES OF AEF
PHYSICOCHEMICAL AND BIOCHEMICAL PROPERTIES OF AEF
IMMUNOLOGICAL AND IMMUNOCHEMICAL PROPERTIES OF AEF
RELATIONSHIP OF AEF TO OTHER BIOLOGICALLY ACTIVE FACTORS
POSSESSING HISTOCOMPATIBILITY ANTIGEN DETERMINANTS
CHAPTER 33.
I-REGION GENE PRODUCTS IN CELL COOPERATION
CHAPTER 34. SUPPRESSIVE ACTIVITY OF LYMPHOID CELL EXTRACTS FROM NON-RESPONDER MICE INJECTED WITH THE TERPOLYMER L-GLUTAMIC ACID60- L-ALANINE30- L-TYROSINE10
(GAT)
COMPARISON OF LYMPHOID CELL EXTRACTS FROM
CONTROL AND GAT-PRIMED MICE
ANTIGENIC SPECIFICITY OF THE EXTRACT
ESTIMATE OF MOLECULAR WEIGHT
CHAPTER 35. ANTI -β2MICROGLOBULIN - A SELECTIVE PBA FOR HUMAN AND MOUSE B
LYMPHOCYTES
THE ACTIVE MITOGENIC PRINCIPLE IN ANTISERA AGAINST
β2MICROGLOBULIN
OPTIMAL CONDITIONS FOR MITOGENICITY OF ANTIBODIES TO
β2MICROGLOBULIN
B CELLS ARE DIRECTLY ACTIVATED BY ANTI-
β2MICROGLOBULIN
DOES ANTI-β2MICROGLOBULIN ACTIVATE A SPECIFIC SUBSET
OF LYMPHOCYTES?
WHICH CELL RECEPTOR IS RESPONSIBLE FOR THE MITOGENIC
ACTION OF ANTI β2MICROGLOBULIN?
GENERAL DISCUSSION - SESSION VI: PROPERTIES OF HISTOCOMPATIBILITY GENE PRODUCTS INVOLVED IN
REGULATION OF IMMUNE RESPONSES
SESSION VII: Biochemistry and Immunocytology of Cell Surface Products of the Major Histocompatibility Complex
CHAPTER 36.
CYTOLOGICAL ANALYSIS OF HISTOCOMPATIBILITY MOLECULES
DISCUSSION FOLLOWING EMIL UNANUE
CHAPTER 37. ISOLATION AND STRUCTURE OF PRODUCTS OF THE HUMAN
HISTOCOMPATIBILITY GENE COMPLEX
HL-A ANTIGENS FROM HUMAN LYMPHOCYTES
B CELL SPECIFIC ANTIGENS FROM HUMAN LYMPHOCYTES
DISCUSSION FOLLOWING JACK STROMINGER
CHAPTER 38. STUDIES ON THE CHEMICAL BASIS OF VARIABILITY AND THE COMPLEX CELLULAR EXPRESSION OF THE H-2K and H-2D PRODUCTS
STUDIES ON THE PEPTIDE ANALYSIS OF SELECTED H-2K AND H-2D GENE PRODUCTS
STUDIES ON THE POLYMORPHISM AND INTRAMOLECULAR ARRANGEMENT OF THE H-2 GLYCOPROTEINS
STUDIES ON SOMATIC CELL VARIANTS IN H-2
EXPRESSION
DISCUSSION FOLLOWING STANLEY NATHENSON
CHAPTER 39.
STRUCTURE AND BIOLOGICAL ACTIVITY OF H-2 ANTIGENS
STRUCTURE OF H-2 ANTIGENS
COMPARISON OF PARTIAL AMINO ACID SEQUENCES
CHAPTER 40. GENETIC AND
EVOLUTIONARY IMPLICATIONS OF THE PARTIAL AMINO ACID SEQUENCES OF H-2K AND H-2D ALLOANTIGENS
CHAPTER 41.
THE CHEMISTRY OF MOUSE AND GUINEA PIG la ANTIGENS
GENERAL DISCUSSION - SESSION VII: BIOCHEMISTRY AND IMMUNOCYTOLOGY OF CELL SURFACE PRODUCTS
OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
SESSION VIII: Interrelationships Between Products of the Major Histocompatibility Complex and Their Relevance to Disease
CHAPTER 42. GENERAL DISCUSSION - SESSION VIII: INTERRELATIONSHIPS BETWEEN PRODUCTS OF THE MAJOR
HISTOCOMPATIBILITY COMPLEX AND THEIR RELEVANCE TO DISEASE
1. a) SPECIFICITY OF H-LINKED
Ir GENE FUNCTION
1. b) MICROHETEROGENEITY OF la MOLECULES
2. EVIDENCE FOR EXISTENCE OF A DISTINCT I-B SUB-REGION
3. a,b,c) NATURE OF THE ANTIGEN RECEPTOR ON T CELL FACTORS AND RELATIONSHIP TO VH REGIONS AND Ig IDIOTYPES; THEIR SPECIFICITY RANGE AS COMPARED TO IMMUNOGLOBULINS; AND POSSIBLE EXISTENCE OF DUAL RECOGNITION SYSTEMS AT THE T CELL LEVEL AND AT OTHER LEVELS
4. SIMILARITIES AND DIFFERENCES BETWEEN HELPER AND SUPPRESSOR FACTORS
5. BASIS FOR THE LARGE NUMBERS OF ALLOSPECIFIC T CELLS RECOGNIZING MHC ANTIGENS
6. THE PHENOMENON OF CIS-TRANS PREFERENCE IN COMPLEMENTATION OF IT GENES AND ITS RELEVANCE TO
LINKAGE DISEQUILIBRIUM IN THE MHC
7. THE BASIS FOR PRESENCE OR ABSENCE OF GENETIC RESTRICTIONS IN
T-B CELL COOPERATION — ADAPTATION OR SELECTION
RELATIONSHIP OF THE MHC TO HUMAN DISEASE
The Role of Products of the Histocompatibility Gene Complex in Immune Responses
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